Jason D. Christie
Paul F. Harron, Jr. Family Professor
Member, Biomedical Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Department of Biostatistics and Epidemiology
Senior Scholar, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania
Adjunct Investigator, Institute for Environmental Medicine, Perelman School of Medicine at the University of Pennsylvania
Chief, Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania
Executive Committee, Penn Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania
Department: Medicine
Graduate Group Affiliations
Contact information
Division of Pulmonary and Critical Care Medicine
Hospital of the University of Pennsylvania
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania School of Medicine
423 Guardian Drive
221 Blockley Hall
Philadelphia, PA 19104
Hospital of the University of Pennsylvania
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania School of Medicine
423 Guardian Drive
221 Blockley Hall
Philadelphia, PA 19104
Office: (215) 573-3209
Fax: (215) 573-0198
Fax: (215) 573-0198
Email:
jchristi@upenn.edu
jchristi@upenn.edu
Publications
Links
Search PubMed for articles
Center for Clinical Epidemiology and Biostatistics faculty webpage
Institute for Translational Medicine and Therapeutics
Search PubMed for articles
Center for Clinical Epidemiology and Biostatistics faculty webpage
Institute for Translational Medicine and Therapeutics
Education:
Sc.B. (Chemistry)
Brown University, 1989.
M.D. (Medicine)
Columbia University, 1993.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, 2002.
Sc.B. (Chemistry)
Brown University, 1989.
M.D. (Medicine)
Columbia University, 1993.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, 2002.
Post-Graduate Training
Resident in Medicine, Hospital of the University of Pennsylvania, 1993-1996.
Chief Medical Resident, Hospital of the University of Pennsylvania, 1996-1997.
Fellow, Division of Pulmonary and Critical Care Medicine, Hospital of the University of Pennsylvania , 1997-2000.
Fellow, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, 1998-2000.
Permanent linkResident in Medicine, Hospital of the University of Pennsylvania, 1993-1996.
Chief Medical Resident, Hospital of the University of Pennsylvania, 1996-1997.
Fellow, Division of Pulmonary and Critical Care Medicine, Hospital of the University of Pennsylvania , 1997-2000.
Fellow, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, 1998-2000.
Description of Research Expertise
Dr. Christie's career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury in the transplant and non-transplant human populations. His research integrates new knowledge generated from bench studies with epidemiology approaches in well-phenotyped, large human populations to generate new definitions of human syndromes, improved diagnostics and prognostics, and targeted therapy approaches in advanced lung diseases and critical illness.Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study the etiology and pathogenesis of acute lung injury following lung transplantation (termed primary graft dysfunction). Active LTOG research themes focus on the mechanisms of clinical factors that elevate PGD risk, including donor smoke exposure, recipient obesity and body composition, pulmonary hypertension, alterations in lung microbiome, and autoimmunity to lung collagens. His multidisciplinary lung transplant research focuses on genetics, innate immunity, regulatory T-cells, innate lymphoid cell (ILC) populations in the lung, ischemia reperfusion injury, inflammation, and autoimmunity.
Description of Itmat Expertise
His career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury in the transplant and non-transplant human populations. Through leadership of the Center for Translational Lung Biology, Dr. Christie brings together clinicians, bench scientists, epidemiologists, and statisticians to build multidisciplinary research teams. His research integrates new knowledge generated from bench studies with epidemiology approaches in well-phenotyped, large human populations to generate new definitions of human syndromes, improved diagnostics and prognostics, and targeted therapy approaches in advanced lung diseases and critical illness.Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study the etiology and pathogenesis of acute lung injury following lung transplantation (termed primary graft dysfunction). Active LTOG research themes focus on the mechanisms of clinical factors that elevate PGD risk, including donor smoke exposure, recipient obesity and body composition, pulmonary hypertension, alterations in lung microbiome, and autoimmunity to lung collagens.
Selected Publications
Anderson MR, Cantu E, Shashaty M, Benvenuto L, Kalman L, Palmer S, Singer JP, Gallop R, Diamond JM, Hsu J, Localio AR, Christie JD.: Body Mass Index and Cause-specific Mortality after Lung Transplantation in the United States. Ann Am Thorac Soc Mar 2023.Singer JP, Christie JD, Diamond JM, Anderson MA, Benvenuto LA, Gao Y, Arcasoy SM, Lederer DJ, Calabrese D, Wang P, Hays SR, Kukreja J, Venado A, Kolaitis NA, Leard LE, Shah RJ, Kleinhenz ME, Golden J, Betancourt L, Oyster M, Zaleski D, Adler J, Kalman L, Balar P, Patel S, Medikonda N, Koons B, Tevald M, Covinsky KE, Greenland JR, Katz PK.: Development of the Lung Transplant Frailty Scale (LT-FS). J Heart Lung Transplant Feb 2023.
Peljto AL, Blumhagen RZ, Walts AD, Cardwell J, Powers J, Corte TJ, Dickinson JL, Glaspole I, Moodley YP, Vasakova MK, Bendstrup E, Davidsen JR, Borie R, Crestani B, Dieude P, Bonella F, Costabel U, Gudmundsson G, Donnelly SC, Egan J, Henry MT, Keane MP, Kennedy MP, McCarthy C, McElroy AN, Olaniyi JA, O'Reilly KMA, Richeldi L, Leone PM, Poletti V, Puppo F, Tomassetti S, Luzzi V, Kokturk N, Mogulkoc N, Fiddler CA, Hirani N, Jenkins G, Maher TM, Molyneaux PL, Parfrey H, Braybrooke R, Blackwell TS, Jackson PD, Nathan SD, Porteous MK, Brown KK, Christie JD, Collard HR, Eickelberg O, Foster EE, Gibson KF, Glassberg M, Kass D, Kropski JA, Lederer D, Linderholm AL, Loyd J, Mathai SK, Montesi SB, Noth I, Oldham JM, Palmisciano AJ, Reichner CA, Rojas M, Roman J, Schluger N, Shea BS, Swigris JJ, Wolters PJ, Zhang Y, Prele CMA, Enghelmayer JI, Otaola M, Ryerson CJ, Salinas M, Sterclova M, Gebremariam TH, Myll�iemi M, Carbone R, Furusawa H, Hirose M, Inoue Y, Miyazaki Y, Ohta K, Ohta S, Okamoto T, Kim DS, Pardo A, Selman M, Aranda AU, Park MS, Park JS, Song JW, Molina-Molina M, Planas-Cerezales L, Westergren-Thorsson G, Smith AV, Manichaikul AW, Kim JS, et al.: Idiopathic Pulmonary Fibrosis Is Associated with Common Genetic Variants and Limited Rare Variants. Am J Respir Crit Care Med 207: 1194-1202, Jan 2023.
Koons B, Aryal S, Blumenthal N, Courtwright A, O'Connor M, Christie JD, Singer JP, Riegel B.: Mismatch identified in symptom burden profiles in lung transplantation. Heart Lung 2023.
Singer JP, Calfee CS, Delucchi K, Diamond JM, Anderson MA, Benvenuto LA, Gao Y, Wang P, Arcasoy SM, Lederer DJ, Hays SR, Kukreja J, Venado A, Kolaitis NA, Leard LE, Shah RJ, Kleinhenz ME, Golden J, Betancourt L, Oyster M, Brown M, Zaleski D, Medikonda N, Kalman L, Balar P, Patel S, Calabrese DR, Greenland JR, Christie JD.: Subphenotypes of frailty in lung transplant candidates. Am J Transplant 2023.
Edward Cantu, Joshua M Diamond, Marisa Cevasco, Yoshi Suzuki, Maria Crespo, Emily Clausen, Laura Dallara, Christian V Ramon, Michael T Harmon, Christian Bermudez, Luke Benvenuto, Michaela Anderson, Keith M Wille, Ann Weinacker, Gundeep S Dhillon, Jonathan Orens, Pali Shah, Christian Merlo, Vibha Lama, John McDyer, Laurie Snyder, Scott Palmer, Matt Hartwig, Chadi A Hage, Jonathan Singer, Carolyn Calfee, Jasleen Kukreja, John R Greenland, Lorraine B Ware, Russel Localio, Jesse Hsu, Robert Gallop, Jason D Christie: Contemporary trends in PGD incidence, outcomes, and therapies. The Journal of heart and lung transplantation 12: 1839-1849, December 2022 Notes: Epub August 2022.
Michael O Harhay, Wida S Cherikh, Alice E Toll, Jason D Christie, Josef Stehlik, Daniel Chambers, Don Hayes Jr, Edward Cantu: Epidemiology, risk factors, and outcomes of lung retransplantation: An analysis of the International Society for Heart and Lung Transplantation Thoracic Transplant Registry. Heart Lung Transplant 10: 1478-1486, October 2022 Notes: Epub July 2022.
John E McGinniss, Samantha A Whiteside, Rebecca A Deek, Aurea Simon-Soro, Jevon Graham-Wooten, Michelle Oyster, Melanie D Brown, Edward Cantu, Joshua M Diamond, Hongzhe Li, Jason D Christie, Frederic D Bushman, Ronald G Collman: The Lung Allograft Microbiome Associates with Pepsin, Inflammation, and Primary Graft Dysfunction. American Journal of Respiratory and Critical Care Medicine 206: 1508-1521, September 2022 Notes: Online ahead of print.
Maria C Basil, Fabian L Cardenas-Diaz, Jaymin J Kathiriya, Michael P Morley, Justine Carl, Alexis N Brumwell, Jeremy Katzen, Katherine J Slovik, Apoorva Babu, Su Zhou, Madison M Kremp, Katherine B McCauley, Shanru Li, Joseph D Planer, Shah S Hussain, Xiaoming Liu, Rebecca Windmueller, Yun Ying, Kathleen M Stewart, Michelle Oyster, Jason D Christie, Joshua M Diamond, John F Engelhardt, Edward Cantu, Steven M Rowe, Darrell N Kotton, Harold A Chapman, Edward E Morrisey: Human distal airways contain a multipotent secretory cell that can regenerate alveoli. Nature 604: 120-126, April 2022 Notes: Epub 2022 Mar 30.
Anderson MR, Aronson KI, Diamond JM, Christie JD, Singer JP.: Current Beliefs and Practices Regarding the Management of Obesity in Patients with Progressive Interstitial Lung Disease. Ann Am Thorac Soc 19: 1602-5, April 2022.