Jason D. Christie

faculty photo
Paul F. Harron, Jr. Family Professor
Member, Biomedical Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Department of Biostatistics and Epidemiology
Senior Scholar, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania
Adjunct Investigator, Institute for Environmental Medicine, Perelman School of Medicine at the University of Pennsylvania
Chief, Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania
Executive Committee, Penn Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania
Department: Medicine

Contact information
Division of Pulmonary and Critical Care Medicine
Hospital of the University of Pennsylvania
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania School of Medicine
423 Guardian Drive
221 Blockley Hall
Philadelphia, PA 19104
Office: (215) 573-3209
Fax: (215) 573-0198
Education:
Sc.B. (Chemistry)
Brown University, 1989.
M.D. (Medicine)
Columbia University, 1993.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, 2002.
Post-Graduate Training
Resident in Medicine, Hospital of the University of Pennsylvania, 1993-1996.
Chief Medical Resident, Hospital of the University of Pennsylvania, 1996-1997.
Fellow, Division of Pulmonary and Critical Care Medicine, Hospital of the University of Pennsylvania , 1997-2000.
Fellow, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, 1998-2000.
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Description of Research Expertise

Dr. Christie's career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury in the transplant and non-transplant human populations. His research integrates new knowledge generated from bench studies with epidemiology approaches in well-phenotyped, large human populations to generate new definitions of human syndromes, improved diagnostics and prognostics, and targeted therapy approaches in advanced lung diseases and critical illness.

Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study the etiology and pathogenesis of acute lung injury following lung transplantation (termed primary graft dysfunction). Active LTOG research themes focus on the mechanisms of clinical factors that elevate PGD risk, including donor smoke exposure, recipient obesity and body composition, pulmonary hypertension, alterations in lung microbiome, and autoimmunity to lung collagens. His multidisciplinary lung transplant research focuses on genetics, innate immunity, regulatory T-cells, innate lymphoid cell (ILC) populations in the lung, ischemia reperfusion injury, inflammation, and autoimmunity.

Description of Itmat Expertise

His career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury in the transplant and non-transplant human populations. Through leadership of the Center for Translational Lung Biology, Dr. Christie brings together clinicians, bench scientists, epidemiologists, and statisticians to build multidisciplinary research teams. His research integrates new knowledge generated from bench studies with epidemiology approaches in well-phenotyped, large human populations to generate new definitions of human syndromes, improved diagnostics and prognostics, and targeted therapy approaches in advanced lung diseases and critical illness.

Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study the etiology and pathogenesis of acute lung injury following lung transplantation (termed primary graft dysfunction). Active LTOG research themes focus on the mechanisms of clinical factors that elevate PGD risk, including donor smoke exposure, recipient obesity and body composition, pulmonary hypertension, alterations in lung microbiome, and autoimmunity to lung collagens.

Selected Publications

Edward Cantu, Joshua M Diamond, Marisa Cevasco, Yoshi Suzuki, Maria Crespo, Emily Clausen, Laura Dallara, Christian V Ramon, Michael T Harmon, Christian Bermudez, Luke Benvenuto, Michaela Anderson, Keith M Wille, Ann Weinacker, Gundeep S Dhillon, Jonathan Orens, Pali Shah, Christian Merlo, Vibha Lama, John McDyer, Laurie Snyder, Scott Palmer, Matt Hartwig, Chadi A Hage, Jonathan Singer, Carolyn Calfee, Jasleen Kukreja, John R Greenland, Lorraine B Ware, Russel Localio, Jesse Hsu, Robert Gallop, Jason D Christie: Contemporary trends in PGD incidence, outcomes, and therapies. The Journal of heart and lung transplantation 12: 1839-1849, December 2022 Notes: Epub August 2022.

Michael O Harhay, Wida S Cherikh, Alice E Toll, Jason D Christie, Josef Stehlik, Daniel Chambers, Don Hayes Jr, Edward Cantu: Epidemiology, risk factors, and outcomes of lung retransplantation: An analysis of the International Society for Heart and Lung Transplantation Thoracic Transplant Registry. Heart Lung Transplant 10: 1478-1486, October 2022 Notes: Epub July 2022.

John E McGinniss, Samantha A Whiteside, Rebecca A Deek, Aurea Simon-Soro, Jevon Graham-Wooten, Michelle Oyster, Melanie D Brown, Edward Cantu, Joshua M Diamond, Hongzhe Li, Jason D Christie, Frederic D Bushman, Ronald G Collman: The Lung Allograft Microbiome Associates with Pepsin, Inflammation, and Primary Graft Dysfunction. American Journal of Respiratory and Critical Care Medicine September 2022 Notes: Online ahead of print.

Maria C Basil, Fabian L Cardenas-Diaz, Jaymin J Kathiriya, Michael P Morley, Justine Carl, Alexis N Brumwell, Jeremy Katzen, Katherine J Slovik, Apoorva Babu, Su Zhou, Madison M Kremp, Katherine B McCauley, Shanru Li, Joseph D Planer, Shah S Hussain, Xiaoming Liu, Rebecca Windmueller, Yun Ying, Kathleen M Stewart, Michelle Oyster, Jason D Christie, Joshua M Diamond, John F Engelhardt, Edward Cantu, Steven M Rowe, Darrell N Kotton, Harold A Chapman, Edward E Morrisey: Human distal airways contain a multipotent secretory cell that can regenerate alveoli. Nature 604: 120-126, April 2022 Notes: Epub 2022 Mar 30.

McQuiston A, Scott D, Nord D, Langerude L, Pelaez A, Machuca T, Mehta A, Drake RR, Christie JD, Angel P, Atkinson C.: Pro-inflammatory IgG1 N-glycan signature correlates with primary graft dysfunction onset in COPD patients. Transpl Immunol. Transplant Immunology April 2022.

Anderson MR, Aronson KI, Diamond JM, Christie JD, Singer JP.: Current Beliefs and Practices Regarding the Management of Obesity in Patients with Progressive Interstitial Lung Disease. Ann Am Thorac Soc April 2022.

Faust HE, Oniyide O, Wang Y, Forker CM, Dunn T, Yang W, Lanken PN, Sims CA, Yehya N, Christie JD, Meyer NJ, Reilly JP, Mangalmurti NS, Shashaty MGS.: Early Plasma Nuclear DNA, Mitochondrial DNA, and Nucleosome Concentrations Are Associated With Acute Kidney Injury in Critically Ill Trauma Patients. Crit Care Explor 4: e0663, March 2022.

Mikacenic C, Bhatraju P, Robinson-Cohen C, Kosamo S, Fohner AE, Dmyterko V, Long SA, Cerosaletti K, Calfee CS, Matthay MA, Walley KR, Russell JA, Christie JD, Meyer NJ, Christiani DC, Wurfel MM.: Single Nucleotide Variant in FAS Associates With Organ Failure and Soluble Fas Cell Surface Death Receptor in Critical Illness. Crit Care Med 50: e284-e293, March 2022.

Farrell CL, Miano TA, Griffiths S, Christie JD, Diamond JM, Shashaty MGS.: Early post-lung transplant calcineurin inhibitor management varies widely: An international survey. Clin Transplant February 2022.

Tatiana Akimova, Tianyi Zhang, Lanette M Christensen, Zhonglin Wang, Rongxiang Han, Dmitry Negorev, Arabinda Samanta, Isaac E Sasson, Trivikram Gaddapara, Jing Jiao, Liqing Wang, Tricia R Bhatti, Matthew H Levine, Joshua M Diamond, Ulf H Beier, Rebecca A Simmons, Edward Cantu, David S Wilkes, David J Lederer, Michaela Anderson, Jason D Christie, Wayne W Hancock : Obesity-related IL-18 Impairs Treg Function and Promotes Lung Ischemia-reperfusion Injury. American Journal of Respiratory and Critical Care Medicine 204(9): 1060-1074, November 2021 Notes: Online ahead of print.

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Last updated: 12/16/2022
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