Rahim R. Rizi

faculty photo
Professor of Radiology
Department: Radiology
Graduate Group Affiliations

Contact information
Department of Radiology
1 Silverstein
3400 Spruce Street
Philadelphia, PA 19104-6100
Office: 215-615-2426
Fax: 215-349-5115
B.S. (Chemistry)
University of Isfahan, Iran, 1976.
M.S. (Physical Chemistry)
Western Illinois University, 1978.
Ph.D. (Physical Chemistry)
University of Iowa , 1983.
M.S. (Computer Science)
University of Pennsylvania , 1987.
Post-Graduate Training
Postdoctoral Fellow, Radiology, University of Penn School of Medicine, 1994-1998.
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Description of Research Expertise

The primary mission of the Functional and Metabolic Imaging Group (FMIG) is the development and application of novel hyperpolarized MRI techniques to the diagnosis of various pulmonary and metabolic disorders. Hyperpolarization, the process of drastically increasing the population difference between nuclear spin states, provides a platform for imaging lung physiology and metabolic activity with spatial and temporal resolution unattainable with conventional MRI techniques, thus offering the potential for the earlier diagnosis of disease states and the precise monitoring of a patient’s response to medical treatment. This core research theme is executed with an eye toward several ultimate goals: the identification of changes in pulmonary structure and function associated with disease, a more complete understanding of pathogenesis, and the establishment of a more sensitive testing environment to develop treatments for lung disease. To date, significant contributions in these areas include new imagining techniques for the comprehensive description of lung physiology and structure, accurate imaging of the regional pulmonary partial pressure of oxygen in both humans and large and small animals, highly developed imaging of regional ventilation, and a state-of-the-art mechanical ventilation device. Specifically, our research activities at FMIG is divided into four general branches: 1) The development of novel imaging techniques for the quantitative assessment of pulmonary structure and function: 2)The development of novel methods for real-time metabolic imaging: 3)The construction of novel polarization apparatuses: 4) The development and implementation of rapid imaging pulse sequences.

Description of Itmat Expertise

Dr. Rizi investigates non-invasive, regional assessment of lung function which has the potential to markedly enhance early diagnosis and management of disease, to accelerate drug discovery and trials, and to provide fundamental insights into lung disease pathogenesis.

Selected Publications

Xin Y, Martin K, Morais CCA, Delvecchio P, Gerard SE, Hamedani H, Herrmann J, Abate N, Lenart A, Humayun S, Sidhu U, Petrov M, Reutlinger K, Mandelbaum T, Duncan I, Tustison N, Kadlecek S, Chatterjee S, Gee JC, Rizi RR, Berra L, Cereda M.: Diminishing Efficacy of Prone Positioning With Late Application in Evolving Lung Injury. Crit Care Med rit Care Med, May 2021.

Amzajerdian F, Ruppert K, Hamedani H, Baron R, Xin Y, Loza L, Achekzai T, Duncan IF, Qian Y, Pourfathi M, Kadlecek S, Rizi RR.: Measuring pulmonary gas exchange using compartment-selective xenon-polarization transfer contrast (XTC) MRI. Magn Reson Med 85: 2709-2722, May 2021.

Rizi RR, Hamedani H, Cereda M.: In Chronic Obstructive Pulmonary Disease Progression, Is It Airway Narrowing or Airway Loss? Am J Respir Crit Care Med 203: 154-155, Jan 2021.

Xin Y, Cereda M, Hamedani H, Martin KT, Tustison NJ, Pourfathi M, Kadlecek S, Siddiqui S, Amzajerdian F, Connell M, Abate N, Kajanaku A, Duncan I, Gee JC, Rizi RR.: Positional Therapy and Regional Pulmonary Ventilation. Anesthesiology 133: 1093-1105, Nov 2020.

Yi Xin, Maurizio Cereda, Hooman Hamedani, Kevin T Martin, Nicholas J Tustison, Mehrdad Pourfathi, Stephen Kadlecek, Sarmad Siddiqui, Faraz Amzajerdian, Marc Connell, Nicholas Abate, Agi Kajanaku, Ian Duncan, James C Gee, Rahim R Rizi: Positional Therapy and Regional Pulmonary Ventilation: High-resolution Alignment of Prone and Supine Computed Tomography Images in a Large Animal Model. Anesthesiology August 2020.

Mehrdad Pourfathi, Yi Xin, Michael Rosalino, Maurizio Cereda, Stephen Kadlecek, Ian Duncan, Harrilla Profka, Hooman Hamedani, Sarmad Siddiqui, Kai Ruppert, Shampa Chatterjee, Rahim R Rizi: Pulmonary pyruvate metabolism as an index of inflammation and injury in a rat model of acute respiratory distress syndrome. NMR in biomedicine 33: e4380, July 2020.

Kai Ruppert, Faraz Amzajerdian, Yi Xin, Hooman Hamedani, Luis Loza, Tahmina Achekzai, Ian F Duncan, Harrilla Profka, Yiwen Qian, Mehrdad Pourfathi, Stephen Kadlecek, Rahim R Rizi: Investigating biases in the measurement of apparent alveolar septal wall thickness with hyperpolarized 129Xe MRI. Magnetic Resonance in Medicine 84: 3027-3039, June 2020.

Loza Luis A, Kadlecek Stephen J, Pourfathi Mehrdad, Hamedani Hooman, Duncan Ian F, Ruppert Kai, Rizi Rahim R: Quantification of Ventilation and Gas Uptake in Free-Breathing Mice with Hyperpolarized 129Xe MRI. IEEE transactions on medical imaging 38: 2081-2091, September 2019.

Siddiqui Sarmad, Habertheuer Andreas, Xin Yi, Pourfathi Mehrdad, Tao Jian-Qin, Hamedani Hooman, Kadlecek Stephen, Duncan Ian, Vallabhajosyula Prashanth, Naji Ali, Chatterjee Shampa, Rizi Rahim: Detection of lung transplant rejection in a rat model using hyperpolarized [1- C] pyruvate-based metabolic imaging. NMR in biomedicine 32: e4107, August 2019.

Ruppert Kai, Amzajerdian Faraz, Hamedani Hooman, Xin Yi, Loza Luis, Achekzai Tahmina, Duncan Ian F, Profka Harrilla, Siddiqui Sarmad, Pourfathi Mehrdad, Sertic Federico, Cereda Maurizio F, Kadlecek Stephen, Rizi Rahim R: Assessment of flip angle-TR equivalence for standardized dissolved-phase imaging of the lung with hyperpolarized 129Xe MRI. Magnetic resonance in medicine 81(3): 1784-1794, Mar 2019.

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Last updated: 05/03/2021
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