Rahim R. Rizi

faculty photo
Professor of Radiology
Department: Radiology

Contact information
Department of Radiology
1 Silverstein
3400 Spruce Street
Philadelphia, PA 19104-6100
Office: 215-615-2426
Fax: 215-349-5115
Graduate Group Affiliations
B.S. (Chemistry)
University of Isfahan, Iran, 1976.
M.S. (Physical Chemistry)
Western Illinois University, 1978.
Ph.D. (Physical Chemistry)
University of Iowa , 1983.
M.S. (Computer Science)
University of Pennsylvania , 1987.
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Description of Research Expertise

The primary mission of the Functional and Metabolic Imaging Group (FMIG) is the development and application of novel hyperpolarized MRI techniques to the diagnosis of various pulmonary and metabolic disorders. Hyperpolarization, the process of drastically increasing the population difference between nuclear spin states, provides a platform for imaging lung physiology and metabolic activity with spatial and temporal resolution unattainable with conventional MRI techniques, thus offering the potential for the earlier diagnosis of disease states and the precise monitoring of a patient’s response to medical treatment. This core research theme is executed with an eye toward several ultimate goals: the identification of changes in pulmonary structure and function associated with disease, a more complete understanding of pathogenesis, and the establishment of a more sensitive testing environment to develop treatments for lung disease. To date, significant contributions in these areas include new imagining techniques for the comprehensive description of lung physiology and structure, accurate imaging of the regional pulmonary partial pressure of oxygen in both humans and large and small animals, highly developed imaging of regional ventilation, and a state-of-the-art mechanical ventilation device. Specifically, our research activities at FMIG is divided into four general branches: 1) The development of novel imaging techniques for the quantitative assessment of pulmonary structure and function: 2)The development of novel methods for real-time metabolic imaging: 3)The construction of novel polarization apparatuses: 4) The development and implementation of rapid imaging pulse sequences.

Description of Itmat Expertise

Dr. Rizi investigates non-invasive, regional assessment of lung function which has the potential to markedly enhance early diagnosis and management of disease, to accelerate drug discovery and trials, and to provide fundamental insights into lung disease pathogenesis.

Selected Publications

Baron Ryan J, Hamedani Hooman, Kadlecek Stephen J, Duncan Ian F, Xin Yi, Siddiqui Sarmad, Pourfathi Mehrdad, Cereda Maurizio, Rizi Rahim R: A Model for Predicting Future FEV1 Decline in Smokers Using Hyperpolarized He Magnetic Resonance Imaging. Academic radiology Aug 2018.

Ruppert Kai, Hamedani Hooman, Amzajerdian Faraz, Xin Yi, Duncan Ian F, Profka Harrilla, Siddiqui Sarmad, Pourfathi Mehrdad, Kadlecek Stephen, Rizi Rahim R: Assessment of Pulmonary Gas Transport in Rabbits Using Hyperpolarized Xenon-129 Magnetic Resonance Imaging. Scientific reports 8(1): 7310, May 2018.

Cereda Maurizio, Xin Yi, Rizi Rahim R: Acute Respiratory Distress Syndrome - Can Data from the Sick Guide Care for the Healthy? American journal of respiratory and critical care medicine May 2018.

Ruppert Kai, Amzajerdian Faraz, Hamedani Hooman, Xin Yi, Loza Luis, Achekzai Tahmina, Duncan Ian F, Profka Harrilla, Siddiqui Sarmad, Pourfathi Mehrdad, Cereda Maurizio F, Kadlecek Stephen, Rizi Rahim R: Rapid assessment of pulmonary gas transport with hyperpolarized 129Xe MRI using a 3D radial double golden-means acquisition with variable flip angles. Magnetic resonance in medicine Apr 2018.

Pourfathi Mehrdad, Cereda Maurizio, Chatterjee Shampa, Xin Yi, Kadlecek Stephen, Duncan Ian, Hamedani Hooman, Siddiqui Sarmad, Profka Harrilla, Ehrich Jason, Ruppert Kai, Rizi Rahim R: Lung Metabolism and Inflammation during Mechanical Ventilation; An Imaging Approach. Scientific reports 8(1): 3525, Feb 2018.

Xin Yi, Cereda Maurizio, Hamedani Hooman, Pourfathi Mehrdad, Siddiqui Sarmad, Meeder Natalie, Kadlecek Stephen, Duncan Ian, Profka Harrilla, Rajaei Jennia, Tustison Nicholas J, Gee James C, Kavanagh Brian P, Rizi Rahim R: Unstable Inflation Causing Injury: Insight from Prone Position and Paired CT Scans. American journal of respiratory and critical care medicine 198(2): 197-207, Feb 2018.

Drachman Nicholas, Kadlecek Stephen, Pourfathi Mehrdad, Xin Yi, Profka Harilla, Rizi Rahim: In vivo pH mapping of injured lungs using hyperpolarized [1-(13) C]pyruvate. Magnetic resonance in medicine 78(3): 1121-1130, Sep 2017.

Hamedani Hooman, Kadlecek Stephen, Xin Yi, Siddiqui Sarmad, Gatens Heather, Naji Joseph, Ishii Masaru, Cereda Maurizio, Rossman Milton, Rizi Rahim: A hybrid multibreath wash-in wash-out lung function quantification scheme in human subjects using hyperpolarized (3) He MRI for simultaneous assessment of specific ventilation, alveolar oxygen tension, oxygen uptake, and air trapping. Magnetic resonance in medicine 78(2): 611-624, Aug 2017.

Drachman Nicholas, Kadlecek Stephen, Duncan Ian, Rizi Rahim: Quantifying reaction kinetics of the non-enzymatic decarboxylation of pyruvate and production of peroxymonocarbonate with hyperpolarized (13)C-NMR. Physical chemistry chemical physics : PCCP 19(29): 19316-19325, Jul 2017.

Cereda Maurizio, Xin Yi, Hamedani Hooman, Bellani Giacomo, Kadlecek Stephen, Clapp Justin, Guerra Luca, Meeder Natalie, Rajaei Jennia, Tustison Nicholas J, Gee James C, Kavanagh Brian P, Rizi Rahim R: Tidal changes on CT and progression of ARDS. Thorax 72(11): 981-989, Jun 2017.

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Last updated: 10/08/2018
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