Rahim R. Rizi

faculty photo
Professor of Radiology
Department: Radiology

Contact information
Department of Radiology
1 Silverstein
3400 Spruce Street
Philadelphia, PA 19104-6100
Office: 215-573-0891
Fax: 215-349-5115
Graduate Group Affiliations
B.S. (Chemistry)
University of Isfahan, Iran, 1976.
M.S. (Physical Chemistry)
Western Illinois University, 1978.
Ph.D. (Physical Chemistry)
University of Iowa , 1983.
M.S. (Computer Science)
University of Pennsylvania , 1987.
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Description of Research Expertise

The primary mission of the Functional and Metabolic Imaging Group (FMIG) is the development and application of novel hyperpolarized MRI techniques to the diagnosis of various pulmonary and metabolic disorders. Hyperpolarization, the process of drastically increasing the population difference between nuclear spin states, provides a platform for imaging lung physiology and metabolic activity with spatial and temporal resolution unattainable with conventional MRI techniques, thus offering the potential for the earlier diagnosis of disease states and the precise monitoring of a patient’s response to medical treatment. This core research theme is executed with an eye toward several ultimate goals: the identification of changes in pulmonary structure and function associated with disease, a more complete understanding of pathogenesis, and the establishment of a more sensitive testing environment to develop treatments for lung disease. To date, significant contributions in these areas include new imagining techniques for the comprehensive description of lung physiology and structure, accurate imaging of the regional pulmonary partial pressure of oxygen in both humans and large and small animals, highly developed imaging of regional ventilation, and a state-of-the-art mechanical ventilation device. Specifically, our research activities at FMIG is divided into four general branches: 1) The development of novel imaging techniques for the quantitative assessment of pulmonary structure and function: 2)The development of novel methods for real-time metabolic imaging: 3)The construction of novel polarization apparatuses: 4) The development and implementation of rapid imaging pulse sequences.

Description of Itmat Expertise

Dr. Rizi investigates non-invasive, regional assessment of lung function which has the potential to markedly enhance early diagnosis and management of disease, to accelerate drug discovery and trials, and to provide fundamental insights into lung disease pathogenesis.

Selected Publications

Hamedani Hooman, Clapp Justin T, Kadlecek Stephen J, Emami Kiarash, Ishii Masaru, Gefter Warren B, Xin Yi, Cereda Maurizio, Shaghaghi Hoora, Siddiqui Sarmad, Rossman Milton D, Rizi Rahim R: Regional Fractional Ventilation by Using Multibreath Wash-in (3)He MR Imaging. Radiology Page: 150495, Jan 2016.

Cereda Maurizio, Xin Yi, Hamedani Hooman, Clapp Justin, Kadlecek Stephen, Meeder Natalie, Zeng Johnathan, Profka Harrilla, Kavanagh Brian P, Rizi Rahim R: Mild Loss of Lung Aeration Augments Stretch in Healthy Lung Regions. Journal of applied physiology (Bethesda, Md. : 1985) Page: jap.00734.2015, Dec 2015.

Cereda Maurizio, Xin Yi, Meeder Natalie, Zeng Johnathan, Jiang YunQing, Hamedani Hooman, Profka Harrilla, Kadlecek Stephen, Clapp Justin, Deshpande Charuhas G, Wu Jue, Gee James C, Kavanagh Brian P, Rizi Rahim R: Visualizing the Propagation of Acute Lung Injury. Anesthesiology 124(1): 121-31, Nov 2015.

Clapp Justin, Hamedani Hooman, Kadlecek Stephen, Xin Yi, Shaghaghi Hoora, Siddiqui Sarmad, Rossman Milton D, Rizi Rahim R: Multibreath alveolar oxygen tension imaging. Magnetic resonance in medicine Oct 2015.

Pourfathi Mehrdad, Clapp Justin, Kadlecek Stephen J, Keenan Caroline D, Ghosh Rajat K, Kuzma Nicholas N, Rizi Rahim R: Low-temperature dynamic nuclear polarization of gases in Frozen mixtures. Magnetic resonance in medicine Oct 2015.

Shaghaghi Hoora, Kadlecek Stephen, Siddiqui Sarmad, Pourfathi Mehrdad, Hamedani Hooman, Clapp Justin, Profka Harrilla, Rizi Rahim: Ascorbic acid prolongs the viability and stability of isolated perfused lungs: A mechanistic study using (31)P and hyperpolarized (13)C NMR. Free radical biology & medicine 89: 62-71, Jul 2015.

Ishii Masaru, Hamedani Hooman, Clapp Justin T, Kadlecek Stephen J, Xin Yi, Gefter Warren B, Rossman Milton D, Rizi Rahim R: Oxygen-weighted Hyperpolarized (3)He MR Imaging: A Short-term Reproducibility Study in Human Subjects. Radiology 277(1): 142038, Jun 2015.

Ghosh Rajat K, Kuzma Nicholas N, Kadlecek Stephen J, Rizi Rahim R: Versatile pulse sequence device to conserve hyperpolarization for NMR and MRI studies. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine May 2015.

Yehya Nadir, Xin Yi, Oquendo Yousi, Cereda Maurizio, Rizi Rahim R, Margulies Susan S: Cecal ligation and puncture accelerates development of ventilator-induced lung injury. American journal of physiology. Lung cellular and molecular physiology 308(5): L443-51, Mar 2015.

Xin Yi, Song Gang, Cereda Maurizio, Kadlecek Stephen, Hamedani Hooman, Jiang Yunqing, Rajaei Jennia, Clapp Justin, Profka Harrilla, Meeder Natalie, Wu Jue, Tustison Nicholas J, Gee James C, Rizi Rahim R: Semiautomatic segmentation of longitudinal computed tomography images in a rat model of lung injury by surfactant depletion. Journal of applied physiology (Bethesda, Md. : 1985) 118(3): 377-85, Feb 2015.

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Last updated: 01/21/2016
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