Rahim R. Rizi

faculty photo
Professor of Radiology
Department: Radiology

Contact information
Department of Radiology
1 Silverstein
3400 Spruce Street
Philadelphia, PA 19104-6100
Office: 215-615-2426
Fax: 215-349-5115
Graduate Group Affiliations
Education:
B.S. (Chemistry)
University of Isfahan, Iran, 1976.
M.S. (Physical Chemistry)
Western Illinois University, 1978.
Ph.D. (Physical Chemistry)
University of Iowa , 1983.
M.S. (Computer Science)
University of Pennsylvania , 1987.
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Description of Research Expertise

The primary mission of the Functional and Metabolic Imaging Group (FMIG) is the development and application of novel hyperpolarized MRI techniques to the diagnosis of various pulmonary and metabolic disorders. Hyperpolarization, the process of drastically increasing the population difference between nuclear spin states, provides a platform for imaging lung physiology and metabolic activity with spatial and temporal resolution unattainable with conventional MRI techniques, thus offering the potential for the earlier diagnosis of disease states and the precise monitoring of a patient’s response to medical treatment. This core research theme is executed with an eye toward several ultimate goals: the identification of changes in pulmonary structure and function associated with disease, a more complete understanding of pathogenesis, and the establishment of a more sensitive testing environment to develop treatments for lung disease. To date, significant contributions in these areas include new imagining techniques for the comprehensive description of lung physiology and structure, accurate imaging of the regional pulmonary partial pressure of oxygen in both humans and large and small animals, highly developed imaging of regional ventilation, and a state-of-the-art mechanical ventilation device. Specifically, our research activities at FMIG is divided into four general branches: 1) The development of novel imaging techniques for the quantitative assessment of pulmonary structure and function: 2)The development of novel methods for real-time metabolic imaging: 3)The construction of novel polarization apparatuses: 4) The development and implementation of rapid imaging pulse sequences.

Description of Itmat Expertise

Dr. Rizi investigates non-invasive, regional assessment of lung function which has the potential to markedly enhance early diagnosis and management of disease, to accelerate drug discovery and trials, and to provide fundamental insights into lung disease pathogenesis.

Selected Publications

Drachman Nicholas, Kadlecek Stephen, Pourfathi Mehrdad, Xin Yi, Profka Harilla, Rizi Rahim: In vivo pH mapping of injured lungs using hyperpolarized [1-(13) C]pyruvate. Magnetic resonance in medicine 78(3): 1121-1130, Sep 2017.

Hamedani Hooman, Kadlecek Stephen, Xin Yi, Siddiqui Sarmad, Gatens Heather, Naji Joseph, Ishii Masaru, Cereda Maurizio, Rossman Milton, Rizi Rahim: A hybrid multibreath wash-in wash-out lung function quantification scheme in human subjects using hyperpolarized (3) He MRI for simultaneous assessment of specific ventilation, alveolar oxygen tension, oxygen uptake, and air trapping. Magnetic resonance in medicine 78(2): 611-624, Aug 2017.

Drachman Nicholas, Kadlecek Stephen, Duncan Ian, Rizi Rahim: Quantifying reaction kinetics of the non-enzymatic decarboxylation of pyruvate and production of peroxymonocarbonate with hyperpolarized (13)C-NMR. Physical chemistry chemical physics : PCCP 19(29): 19316-19325, Jul 2017.

Cereda Maurizio, Xin Yi, Hamedani Hooman, Bellani Giacomo, Kadlecek Stephen, Clapp Justin, Guerra Luca, Meeder Natalie, Rajaei Jennia, Tustison Nicholas J, Gee James C, Kavanagh Brian P, Rizi Rahim R: Tidal changes on CT and progression of ARDS. Thorax Jun 2017.

Xin Yi, Cereda Maurizio, Kadlecek Stephen, Emami Kiarash, Hamedani Hooman, Duncan Ian, Rajaei Jennia, Hughes Liam, Meeder Natalie, Naji Joseph, Profka Harrilla, Bolognese Brian J, Foley Joseph P, Podolin Patricia L, Rizi Rahim R: Hyperpolarized Gas Diffusion MRI of Biphasic Lung Inflation in Short and Long Term Emphysema Models. American journal of physiology. Lung cellular and molecular physiology 313(2): ajplung.00048.2017, May 2017.

Siddiqui Sarmad, Kadlecek Stephen, Pourfathi Mehrdad, Xin Yi, Mannherz William, Hamedani Hooman, Drachman Nicholas, Ruppert Kai, Clapp Justin, Rizi Rahim: The use of hyperpolarized carbon-13 magnetic resonance for molecular imaging. Advanced drug delivery reviews 113: 3-23, Apr 2017.

Pourfathi Mehrdad, Xin Yi, Kadlecek Stephen J, Cereda Maurizio F, Profka Harrilla, Hamedani Hooman, Siddiqui Sarmad M, Ruppert Kai, Drachman Nicholas A, Rajaei Jennia N, Rizi Rahim R: In vivo imaging of the progression of acute lung injury using hyperpolarized [1-(13) C] pyruvate. Magnetic resonance in medicine Jan 2017.

Xu He N, Kadlececk Stephen, Shaghaghi Hoora, Zhao Huaqing, Profka Harilla, Pourfathi Mehrdad, Rizi Rahim, Li Lin Z: Differentiating inflamed and normal lungs by the apparent reaction rate constants of lactate dehydrogenase probed by hyperpolarized (13)C labeled pyruvate. Quantitative imaging in medicine and surgery 6(1): 57-66, Feb 2016.

Hamedani Hooman, Clapp Justin T, Kadlecek Stephen J, Emami Kiarash, Ishii Masaru, Gefter Warren B, Xin Yi, Cereda Maurizio, Shaghaghi Hoora, Siddiqui Sarmad, Rossman Milton D, Rizi Rahim R: Regional Fractional Ventilation by Using Multibreath Wash-in (3)He MR Imaging. Radiology 279(3): 150495, Jan 2016.

Cereda Maurizio, Xin Yi, Hamedani Hooman, Clapp Justin, Kadlecek Stephen, Meeder Natalie, Zeng Johnathan, Profka Harrilla, Kavanagh Brian P, Rizi Rahim R: Mild Loss of Lung Aeration Augments Stretch in Healthy Lung Regions. Journal of applied physiology (Bethesda, Md. : 1985) 120(4): jap.00734.2015, Dec 2015.

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Last updated: 09/18/2017
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