Douglas B. Cines

faculty photo
Professor of Pathology and Laboratory Medicine
Director, Faculty Development, University of Pennsylvania, Perlman School of Medicine
Department: Pathology and Laboratory Medicine

Contact information
Dept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania
Philadelphia, PA 19104
Office: 215-662-3966
Fax: 215-573-2012
A.B. (History, PreMed)
New York University, 1968.
M.D. (Medicine)
New York University School of Medicine, 1972.
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Description of Research Expertise

Thormbosis, fibrinolysis, vascular biology, immunohematology

Description of Itmat Expertise

Dr. Cines works on the delivery of plasminogen activators, among other therapeutics, for the prevention and treatment of thrombotic disorders.

Selected Publications

Stepanova. V., Atochina-Vasserman, E., Dergilev, K.B., Tsokolaeva, Z., Parfenova, Y., Teter, M., Holman, K., Volgina, A., Cines, D.B. and Krymskaya, V.P. : Urokinase type plasminogen activator (uPA) in the pathogenesis of LAM. LAM symposium 2015.

Armstead, W.M., Riley, J., Yarovoi, S.V., Higazi, A.-A.R. and Cines, D.B: tPA variant tPA-A296-299 prevents impairment of cerebral autoregulation after stroke through inhibition of JNK and upregulation of p38 MAPK. Internat. Cerebral Blood Flow Society 2015.

Tutweiler, V., Litvinov, R.I., Lozhkin, A.P., Peshkova, A.D., Lebedeva, T., Ataullakhanov, F.I., Cines, D.B. and Weisel, J.W. : Efficacy and mechanism of clot contraction are determined by blood composition. ISTH 2015.

Cuker, A., Lebedeva, T., Husseinzadeh, H., Massefski, W., Marturano, J., Lowery T., Abrams, C. and Cines, D.B.: T2MR platelet analysis correlated with LTA and reveals unique details of ADP-mediated platelet activation in whole blood. ISTH 2015.

Bao, J., Bdeir, K., Siegel, D.L., Cines, D.B. and Zheng, X.L. : Inhibition of ADAMTS13 activity by human neutrophil peptide 1 (HNP-1): potential link between inflammation, onset of thrombotic thrombocytopenic purpura, and other thrombosis. Am Soc Hematol. Dec 2014.

Hayes, V., Johnston, I., Cines, D.B., Rauova, L., Poncz, M. : New insights into the prothrombotic state of heparin-induced thrombocytopenia (HIT): The endothelial lining and “rolling barrage” of activation. Am Soc Hematol Dec 2014.

Ahn, H.-S., Fuentes, R., Hayes, V., Cines, D.B., Muzykantov, V., Zaytsev, S. and Poncz, M.: A human-specific, platelet-targeted, thrombin-activatable urokinase (PLT/uPA-T) demonstrates high thromboprophylactic properties in two in vivo models. Am Soc Hematol. Dec 2014.

Madeeva, D., Tutweiler, V., Cines, D.B., Poncz, M. and Rauova. L. : Monocytes contribute to the prothrombotic nature of heparin-induced thrombocytopenia via activation through FcγRIIA. Am Soc Hematol. Dec 2014.

Cai, Z., Yarovoi, S.V., Zhu, Z., Rauova, L., Lebedeva, T., Poncz, M., Arepally, G., Cines, D.B and Greene. M.I. : Atomic level description of the immune complex that causes heparin-induced thrombocytopenia (HIT) Am Soc Hematol., Dec 2014.

Tutwiler V., Litvinov R.I., Lebedeva T., Ataullkkhanov, F.I., Cines D.B., and Weisel J.W: Effects of platelets and erythrocytes on the dynamic size and mechanical properties of blood clots during contraction. Am Soc Hematol. Dec 2014.

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Last updated: 02/13/2015
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