Douglas B. Cines

faculty photo
Professor of Pathology and Laboratory Medicine
Director, Faculty Development, University of Pennsylvania, Perlman School of Medicine
Department: Pathology and Laboratory Medicine

Contact information
Dept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania
Philadelphia, PA 19104
Office: 215-662-3966
Fax: 215-573-2012
A.B. (History, PreMed)
New York University, 1968.
M.D. (Medicine)
New York University School of Medicine, 1972.
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Description of Research Expertise

Thormbosis, fibrinolysis, vascular biology, immunohematology

Description of Itmat Expertise

Dr. Cines works on the delivery of plasminogen activators, among other therapeutics, for the prevention and treatment of thrombotic disorders.

Selected Publications

Hijazi N, Abu Fanne R, Abramovich R, Yarovoi S, Higazi M, Abdeen S, Basheer M, Maraga E, Cines DB, Higazi AA.: Endogenous plasminogen activators mediate progressive intracranial hemorrhage after traumatic brain injury. Blood 125(16): 2558-65, April 2015.

Pickens, B., Mao, Y., Li, D., Siegel, D.L., Poncz, M., Cines, D.B. and Zheng, X.L. : Platelet-delivered ADAMTS13 inhibits arterial thrombosis and prevents murine models of thrombotic thrombocytopenic purpura. Blood 125(21): 3326-34, 2015.

Cuker, A., Luning Prak, E.T., and Cines, D.B: Can immune thrombocytopenia be cured with medical therapy? Seminars in Hemost. Thromb. 41(4): 395-404, 2015.

Pillai, V.G., Bao, J., McDaniel, J., Zander, C.B., Cao, W., Bdeir, Kh., Cines, D.B. and Zheng, X.L. : Human neutrophil peptides (HNPs) enhance thrombus formation under flow by inhibiting proteolytic activity of plasma ADAMTS13 Metalloprotease. Am Soc Hematol 2015.

Johnston, I., Hayes, V., Cines, D., and Poncz, M. : A targeted photochemical microfluidic vascular injury model for in vitro thrombosis studies: Usage in heparin-induced thrombocytopenia (HIT). Am Soc Hematol 2015.

Cines, D., Villa, C., Muzykantov V. : The emerging role of red blood cells in hemostasis: Opportunity for intervention. Vox Sanguinis Suppl 1, 2015.

Andreeva, I., Hayes, V., Madeeva, D., Litvinov, R.I., Cines, D.B., Poncz, M., Weisel, J.W. and Raouva, L. : Monocyte membrane remodeling by pathogenic antibodies underlies monocyte activation in heparin-induced thrombocytopenia. Am Soc Hematol 2015.

Tutweiler, V., Litvinov, R.I., Lozhkin, A.P., Peshkova, A.D., Lebedeva, T., Ataullakhanov, F.I., Cines, D.B. and Weisel, J.W. : Efficacy and mechanism of clot contraction are determined by blood composition. ISTH 2015.

Cuker, A., Lebedeva, T., Husseinzadeh, H., Massefski, W., Marturano, J., Lowery T., Abrams, C. and Cines, D.B.: T2MR platelet analysis correlated with LTA and reveals unique details of ADP-mediated platelet activation in whole blood. ISTH 2015.

Stepanova. V., Atochina-Vasserman, E., Dergilev, K.B., Tsokolaeva, Z., Parfenova, Y., Teter, M., Holman, K., Volgina, A., Cines, D.B. and Krymskaya, V.P. : Urokinase type plasminogen activator (uPA) in the pathogenesis of LAM. LAM symposium 2015.

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Last updated: 08/04/2015
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