Douglas B. Cines

faculty photo
Professor of Pathology and Laboratory Medicine
Director, Faculty Development, University of Pennsylvania, Perlman School of Medicine
Department: Pathology and Laboratory Medicine

Contact information
Dept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania
Philadelphia, PA 19104
Office: 215-662-3966
Fax: 215-573-2012
Education:
A.B. (History, PreMed)
New York University, 1968.
M.D. (Medicine)
New York University School of Medicine, 1972.
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Description of Research Expertise

Thormbosis, fibrinolysis, vascular biology, immunohematology

Description of Itmat Expertise

Dr. Cines works on the delivery of plasminogen activators, among other therapeutics, for the prevention and treatment of thrombotic disorders.

Selected Publications

Husseinzadeh, H., Cuker, A., Lebeveda, T., Massefski, W., Marturano, J., Lowery, T., Abrams, C. and Cines, D.B.: T2MR platelet analysis agrees with LTA and enables facile detection of platelet disorders in microliter volumes of blood. THSNA April 2016.

Florova, G., Azghani, A.O., Karandashova, S., Schaefer, C., Yarovoi, S.V., Declerck, P.J., Cines, D.B., Idell, S., and Komissarov, A.A.: The slow rate of fibrinolysis limits inhibitor selection when targeting plasminogen activator inhibitor 1 to enhance intrapleural fibrinolytic therapy. American Thoracic Society Dec 2015.

Cines, D.B., Gernsheimer, T., Wasser, J., Godeau, B., Provan, D., Lyons, R., Altomare, I., Wang, X., and Lopez, A. : Integrated analysis of long-term safety in patients with chronic immune thrombocytopenic purpura (ITP) treated with the thrombopoetin (TPO) receptor agonist romiplostim. Int. J. Hematol. 102(3): 259-270, Sep 2015.

Cai, Z., Yarovoi, S.V., Zhu, Z., Rauova, L., Hayes, V., Lebedeva, R., Li, Q., Poncz, M., Cines, D.B.* and Greene, M.I.* (*equal contribution). : Atomic description of the immune complex that causes heparin-induced thrombocytopenia. Nature Communic. Sep 2015.

Jogelekar, M., Khandelwal, SL. Cines, D.B., Poncz, M., Rauova, L. and Arepally, G. M. : Heparin enhances the uptake of PF4/heparin complexes by monocytes and macrophages. J. Thromb Haemost. 13(8): 1416-27, Aug 2015.

Pickens, B., Mao, Y., Li, D., Siegel, D.L., Poncz, M., Cines, D.B. and Zheng, X.L. : Platelet-delivered ADAMTS13 inhibits arterial thrombosis and prevents murine models of thrombotic thrombocytopenic purpura. Blood 125(21): 3326-34, May 2015.

Hijazi N, Abu Fanne R, Abramovich R, Yarovoi S, Higazi M, Abdeen S, Basheer M, Maraga E, Cines DB, Higazi AA.: Endogenous plasminogen activators mediate progressive intracranial hemorrhage after traumatic brain injury. Blood 125(16): 2558-65, April 2015.

Villa, C.H., Greineder, C.F., Johnston, I., Pan, D.C., Carnemolla, R., Cines, D.B., Poncz, M., Siegel, S.L. and Myzkantov, V.: Thrombomodulin Fusion Proteins Coupled to Human Erythrocytes Demonstrate Anti-Thrombotic and Anti-Inflammatory Activity. Am Soc Hematol 2015.

Armstead, W.M., Riley, J., Yarovoi, S., Higazi A.A.-R., and Cines, D.B.: tPA Variant tPA-A296-299 Prevents impairment of cerebral autoregulation after stroke through LRP dependent increase in cAMP and p38 MAPK. Am. Heart Assoc. 2015.

Cuker, A., Luning Prak, E.T., and Cines, D.B.: Can immune thrombocytopenia be cured with medical therapy? Seminars in Hemost. Thromb 41(4): 395-404, 2015.

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Last updated: 12/15/2015
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