Timothy C. Zhu

faculty photo
Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Associate Director, Photodynamic Therapy Physics Research, University of Pennsylvania
Department: Radiation Oncology

Contact information
Department of Radiation Oncology
Perelman Center for Advanced Medicine
University of Pennsylvania
3400 Civic Center Blvd, TRC W 4th floor
Philadelphia, PA 19104
Office: 215-662-4043
Fax: 215-615-5600
BS (Electric Engineering)
Fudan University, Shanghai, China , 1984.
M.Sc. (Physics)
Brown University , 1987.
M.Sc. (Engineering)
Brown University , 1988.
Ph.D. (Physics)
Brown University, 1991.
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Description of Research Expertise

My research focuses on PDT physics, in-vivo dosimetry, and external beam treatment planning. The first area involves the development of explicit and implicit dosimetry of PDT and light fluence rate calculation. The second area involves development of diode in-vivo dosimetry for point dose, EPID and Cherenkov imaging for real-time and planar dose of Radiation beams. The third area involves development of benchmark database for external beams (electron, photon, and proton) and image co-registrations. I have developed an integrated system for interstitial PDT light delivery and dosimetry for bulky tumors, including prostate and H&N cancers. A real-time treatment planning system is developed for intracavitory PDT utilizing an IR navigation system to track the real-time movement of the light source, including Pleural PDT. These techniques utilizes real-time feedback of light dosimetry to inform the 3D volumetric or 2D superficial light fluence calculations for PDT in heterogeneous environment. As a board certified Physicist in radiation oncology, I have been involved in the development of computational treatment planning system for external beams, medical imaging registration, radiation dose calculation, and patient motion monitoring.

Description of Itmat Expertise

Dr. Zhu is interested in the development of an integrated system for image-guided radiation therapy and photodynamic therapy (PDT).

Selected Publications

Pogue BW, Zhu TC, Ntziachristos V, Paulsen KD, Wilson BC, Pfefer J, Nordstrom RJ, Litorja M, Wabnitz H, Chen Y, Gioux S, Tromberg BJ, Yodh AG: Fluorescence-Guided Surgery and Intervention - An AAPM Emerging Technology Blue Paper. Med Phys 45(6): 2681-2688, June 2018 Notes: doi: 10.1002/mp.12909.

George X. Ding, Parham Alaei, Bruce Curran, Ryan Thomas Flynn, Michael S. Gossman, Thomas R. Mackie, Moyed M. Miften, Richard L. Morin, X. George Xu, Timothy C. Zhu : Image Guidance Doses Delivered During Radiotherapy: Quantification, Management, and Reduction: Report of the AAPM Therapy Physics Committee Task Group 180. Med Phys 45(5): e84-e99, May 2018 Notes: doi:10.1002/mp.12824.

Peter H. Ahn, Jarod C Finlay, Shannon M Gallagher-Colombo, Harry Quon, Bert W. O'Malloy, Thomas Sollecito, Martin Greenberg, Charles B. Simone II, Sally McNulty, Alexander Lin, Timothy C. Zhu, Virginia Livolsi, Michael Feldman, Rosemarie Mick, Keith A. Cengel, Theresa M. Busch: Lesion Oxygenation Associates with Clinical Outcomes in Premalignant and Early Stage Head and Neck Tumors Treated on a Phase 1 Trial of Photodynamic Therapy. Photodiagnosis and Photodynamic Therapy 21: 28-35, Feb 2018 Notes: DOI:10.1016/j.pdpdt.2017.10.015.

Yihong Ong, Michele M Kim, Jarod C. Finlay, Andreea Dimofte, Sunil Singhal, Eli Glatstein, Keith Cengel, Timothy C Zhu (senor author): PDT dose dosimetry for photofrin-mediated pleural photodynamic therapy (pPDT). Phys Med Biol 63(1): 015031, Dec 2017 Notes: Doi:10.1088/1361-6560/aa9874.

Prabhu P. Mohapatra, Callistus O. Chiemezie, Arina Kligman, Michele M. Kim, Theresa M. Busch, Timothy C. Zhu and Alexander Greer: 31P NMR Evidence for Peroxide Intermediates in Lipid Emulsion Photooxidations: Phosphine Substituent Effects in Trapping. Photochem photobiol 93(6): 1430-1438, November/December 2017 Notes: DOI: 10.1111/php.12810.

Rozhin Penjweini, Michele M Kim, Timothy C. Zhu (senior author): Three-dimensional finite-element based deformable image registration for evaluation of pleural cavity irradiation during photodynamic therapy. Med Phys 44(7): 3767 - 3775, July 2017 Notes: DOI:10.1002/mp.12284.

Haixia Qiu, Michele M. Kim, Rozhin Penjweini, Jarod C. Finlay, Theresa M. Busch, Tianhao Wang, Wenshen Guo, Keith A. Cengel, Charles B. Simone II, Eli Glatstein, Timothy C. Zhu (senior author): A comparison of dose metrics to predict local tumor control for photofrin-mediated photodynamic therapy. Photochem. Photobiol. 93(4): 1115-1122, Jul 2017 Notes: DOI:10.1111/php.12719.

Michele M. Kim, Ashwini A. Ghogare, Alexander Greer, and Timothy C. Zhu (senior author): On the in-vivo photochemical rate parameters for PDT reactive oxygen species modeling. Phys Med Biol 62(5): R1-R48, March 2017 Notes: DOI:10.1088/1361-6560/62/5/R1.

Indra J Das, Aaron Andersen, Zhe (Jay) Chen, Andrea Dimofte, Eli Glatstein, Jeremy Hoisak, Long Huang, Mark P. Langer, Choonik Lee, Matthew Pacella, Richard A. Popple, Roger Rice, Jennifer Smilowitz, Patricia Sponseller, Timothy Zhu: State of Dose Prescription and Compliance to International Standard (ICRU-83) in Intensity Modulated Radiation Therapy among Academic Institutions. Practical Radiation Oncology 7: e145-e155, March 2017 Notes: DOI:10.1016/j.prro.2016.11.003.

Michele M. Kim, Rozhin Penjweini, Timothy C. Zhu (senior author): Evaluation of singlet oxygen explicit dosimetry (SOED) for predicting treatment outcomes of benzoporphyrin derivative monoacid ring A (BPD-MA)-mediated photodynamic therapy. J Biomed. Opt. 22: 028002, Feb 2017 Notes: DOI:10.1117/1.JBO.22.2.028002.

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Last updated: 10/08/2018
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