Timothy C. Zhu

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Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Associate Director, Photodynamic Therapy Physics Research, University of Pennsylvania
Department: Radiation Oncology

Contact information
Department of Radiation Oncology
Perelman Center for Advanced Medicine
University of Pennsylvania
3400 Civic Center Blvd, TRC W 4th floor
Philadelphia, PA 19104
Office: 215-662-4043
Fax: 215-615-5600
BS (Electric Engineering)
Fudan University, Shanghai, China , 1984.
M.Sc. (Physics)
Brown University , 1987.
M.Sc. (Engineering)
Brown University , 1988.
Ph.D. (Physics)
Brown University, 1991.
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Description of Research Expertise

My research focuses on PDT physics and external beam treatment planning. The first area involves the development of explicit and implicit dosimetry of PDT and light fluence rate calculation. The second area involves development of benchmark database for external beams (electron, photon, and proton) and image co-registrations. I have developed an integrated system for interstitial PDT light delivery and dosimetry for bulky tumors, including prostate and H&N cancers. A real-time treatment planning system is developed for intracavitory PDT utilizing an IR navigation system to track the real-time movement of the light source, including Pleural PDT. These techniques utilizes real-time feedback of light dosimetry to inform the 3D volumetric or 2D superficial light fluence calculations for PDT in heterogeneous environment. As a board certified Physicist in radiation oncology, I have been involved in the development of computational treatment planning system for external beams, medical imaging registration, radiation dose calculation, and patient motion monitoring.

Description of Itmat Expertise

Dr. Zhu is interested in the development of an integrated system for image-guided radiation therapy and photodynamic therapy (PDT).

Selected Publications

Peter H. Ahn, Harry Quon, Bert W. O’Malley, Gregory Weinstein, Ara Chalian, Kelly Malloy, Joshua H. Atkins, Thomas Sollecito, Martin Greenberg, Sally McNulty, Alexander Lin, Timothy C. Zhu, Jarod C. Finlay, Keith Cengel, Virginia Livolsi, Michael Feldman, Rosemarie Mick, Theresa M. Busch: Toxicities and Early Outcomes in a Phase 1 Trial of Photodynamic Therapy for Premalignant and Early Stage Head and Neck Tumors. oral Oncology 54: In press, Feb 2016 Notes: doi: 10.1016/j.oraloncology.2016.01.013.

N. R. Gemmell, A. McCarthy, M.M. Kim, I. Veilleux, T. C. Zhu, G.S. Buller, B. C. Wilson, R. H. Hadfield: A compact Fiber Optic Probe-based Singlet Oxygen Luminescence Detection System. J Biophotonics submitted 2016.

Rozhin Penjweini, Baochang Liu, Michele M. Kim, Timothy C. Zhu (senior author): Explicit dosimetry for 2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH) mediated photodynamic therapy: macroscopic singlet oxygen modeling. J. Biomed. Opt. 20(12): 128003, Dec 2015 Notes: doi: 10.1117/1.JBO.20.12.128003.

Gallagher-Colombo SM, Quon H, Malloy KM, Ahn PH, Cengel KA, Simone CB 2nd, Chalian AA, O'Malley BW, Weinstein GS, Zhu TC, Putt ME, Finlay JC, Busch TM: Measuring the Physiologic Properties of Oral Lesions Receiving Fractionated Photodynamic Therapy. Photochem. Photobiol. 91(5): 1210-8, Sept 2015.

Saumil J. Gandhi, Xing Liang, Xuanfeng Ding, Timothy C. Zhu, Edgar Ben-Josef, John P. Plastaras, James M. Metz, Stefan Both, Smith Apisarnthanarax: Clinical decision tool for optimal delivery of liver stereotactic body radiation therapy: Photons versus protons. Practical Radiation Oncology 5(4): 209-218, June 2015 Notes: DOI: http://dx.doi.org/10.1016/j.prro.2015.01.004.

Timothy C. Zhu, Baochang Liu, and Rozhin Penjweini: Study of tissue oxygen supply rate in a macroscopic PDT singlet oxygen model. J. Biomed. Opt. 20(3): 038001, March 2015.

Timothy C. Zhu, Xing Liang, Michele M Kim, Jarod C. Finlay, Andreea Dimofte, Carmen Rodriguez, Charles B. Simone, Joseph S Friedberg and Keith A Cengel: An IR Navigation System for Pleural PDT Front. Phys. 3: 9, March 2015 Notes: doi: 10.3389/fphy.2015.00009.

Yuichi Akino, Indra Das, Timothy C. Zhu, Subhas C. Sharma: Parameterization of electron beam output factor. Phys Med 31(4): 420-4, Feb 2015 Notes: http://dx.doi.org/10.1016/j.ejmp.2015.02.006.

Timothy C. Zhu, Michele M. Kim, Xing Liang, Jarod C. Finlay, and Theresa M. Busch: In-vivo singlet oxygen threshold doses for PDT. Photon Lasers Med 4(1): 59-71, Feb 2015.

Timothy C. Zhu, Chris Bonnerup, Valdir C. Colussi, Marla L. Dowell, Jarod C. Finlay, Lothar Lilge, Thomas W. Slowey, Claudio Sibata: Absolute Calibration of Optical Power for PDT: Report of AAPM TG140. Med Phys 40(8): 081501 1-13, August 2013.

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Last updated: 05/10/2016
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