Steven M. Albelda

faculty photo
William Maul Measey Professor of Medicine
Member, Penn Cancer Center
Co-Director, Thoracic Oncology Research Laboratory, University of Pennsylvania
Director of Lung Research, Pulmonary, Allergy, and Critical Care, University of Pennsylvania
Vice Chief, Pulmonary and Critical Care, University of Pennsylvania
Founding Member, Center for Cancer Pharmacology
Co-Director. Translational Center of Excellence in Lung Cancer, Abramson Cancer Center
Department: Medicine

Contact information
1016B Abramson Research Center
3615 Civic Center Boulevard
Philadelphia, PA 19104
Office: (215) 573-9933
Fax: (215) 573-4469
Graduate Group Affiliations
B.A. (Chemistry)
Williams College, 1975.
University of Pennsylvania, 1979.
Permanent link

Description of Research Expertise

Immuno-gene Therapy for Thoracic Malignancies
Lung cancer and other thoracic malignancies are the leading cause of cancer deaths in the United States today. The Thoracic Oncology Research Laboratory is focusing on the design of new treatment strategies for lung cancer and mesothelioma based on the rapidly evolving disciplines of molecular biology, immunotherapy, and gene therapy.
Dr. Albelda’s research is translational in focus and includes animal models, work with human tumor samples, and the conduct of clinical trials. This work is primarily funded through a recently renewed Program Project from the National Cancer Institute and participation in a number of RO1 grants.
The tumor microenvironment is one area of active study. Studies are underway with the goals of 1) a better understanding of the biology of the tumor microenvironment with a focus on the immunuosuppressive activities of white blood cells and fibroblasts, 2) novel approaches to alter the tumor microenvironment to enhance immunotherapy including studying effects using COX-2 inhibitors, TGFbeta inhibitors, T-regulatory cell inhibitors., antibodies against B-cells, and chemotherapeutic drugs. A second area of interest in the lab is the use of adoptive T cell transfer to treat lung malignancies. Studies are underway to modify T cells in order to make them traffic more efficiently into tumors, to have better killing function, and to resist inactivation by the tumor microenvironment. A T cells targeting cancer-associated fibroblasts is being developed. In addition, Dr. Albelda is closely involved with a number of immunogene clinical trials at Penn using an adenovirus expressing the immune-activator interferon-alpha that is instilled into the pleural space of mesothelioma patients (in collaboration with Dr. Daniel Sterman) and T cells altered to attack the mesothelioma tumor target, mesothelin (in collaboration with Drs. Carl June and Andrew Haas).

Description of Itmat Expertise

Dr. Albelda's lab is interested in translational approaches to lung cancer and mesothelioma. Preclinical studies evaluate new treatments in animal models, genetic and genomic studies using human blood and cancer tissue samples, and clinical trials of novel therapeutics.

Selected Publications

Kennedy Gregory T, Okusanya Olugbenga T, Keating Jane J, Heitjan Daniel F, Deshpande Charuhas, Litzky Leslie A, Albelda Steven M, Drebin Jeffrey A, Nie Shuming, Low Philip S, Singhal Sunil: The Optical Biopsy: A Novel Technique for Rapid Intraoperative Diagnosis of Primary Pulmonary Adenocarcinomas. Annals of surgery 262(4): 602-9, Oct 2015.

Moon Edmund K, Ranganathan Raghuveer, Eruslanov Evgeniy, Kim Soyeon, Newick Kheng, O'Brien Shaun, Lo Albert, Liu Xiaojun, Zhao Yangbing, Albelda Steven M: Blockade of Programmed Death 1 Augments the Ability of Human T cells Engineered to Target NY-ESO-1 to Control Tumor Growth after Adoptive Transfer. Clinical cancer research : an official journal of the American Association for Cancer Research Aug 2015.

Fridlender Zvi G, Albelda Steven M, Granot Zvi: Promoting metastasis: neutrophils and T cells join forces. Cell research 25(7): 765-6, Jul 2015.

Lo Albert, Wang Liang-Chuan S, Scholler John, Monslow James, Avery Diana, Newick Kheng, O'Brien Shaun, Evans Rebecca A, Bajor David J, Clendenin Cynthia, Durham Amy C, Buza Elizabeth L, Vonderheide Robert H, June Carl H, Albelda Steven M, Puré Ellen: Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells. Cancer research 75(14): 2800-10, Jul 2015.

Kennedy Gregory T, Judy Brendan F, Bhojnagarwala Pratik, Moon Edmund K, Fridlender Zvi G, Albelda Steven M, Singhal Sunil: Surgical cytoreduction restores the antitumor efficacy of a Listeria monocytogenes vaccine in malignant pleural mesothelioma. Immunology letters 166(1): 28-35, Jul 2015.

Mesaros Clementina, Worth Andrew J, Snyder Nathaniel W, Christofidou-Solomidou Melpo, Vachani Anil, Albelda Steven M, Blair Ian A: Bioanalytical techniques for detecting biomarkers of response to human asbestos exposure. Bioanalysis 7(9): 1157-73, July 2015.

Enxiu Wang, E., Wang, L.C., Tsai, C.Y., Bhoj, V., Moon, E., Newick, K., Sun, J., Lo A., Puré, E., Baradet, T., Feldman, M., Albelda, S.M., Milone, M.C. : Killer Immunoglobulin-like Receptor (KIR)-based Chimeric Antigen Receptors (CARs) for Adoptive T cell Immunotherapy. Cancer Immunology Research 7: 815-26, 2015.

Eruslanov Evgeniy B, Bhojnagarwala Pratik S, Quatromoni Jon G, Stephen Tom Li, Ranganathan Anjana, Deshpande Charuhas, Akimova Tatiana, Vachani Anil, Litzky Leslie, Hancock Wayne W, Conejo-Garcia José R, Feldman Michael, Albelda Steven M, Singhal Sunil: Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer. The Journal of clinical investigation 124(12): 5466-80, Dec 2014.

Okusanya Olugbenga T, Holt David, Heitjan Daniel, Deshpande Charuhas, Venegas Ollin, Jiang Jack, Judy Ryan, DeJesus Elizabeth, Madajewski Brian, Oh Kenny, Wang May, Albelda Steven M, Nie Shuming, Singhal Sunil: Intraoperative near-infrared imaging can identify pulmonary nodules. The Annals of thoracic surgery 98(4): 1223-30, Oct 2014.

Moon Edmund K, Wang Liang-Chuan, Dolfi Douglas V, Wilson Caleph B, Ranganathan Raghuveer, Sun Jing, Kapoor Veena, Scholler John, Puré Ellen, Milone Michael C, June Carl H, Riley James L, Wherry E John, Albelda Steven M: Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor-transduced human T cells in solid tumors. Clinical cancer research : an official journal of the American Association for Cancer Research 20(16): 4262-73, Aug 2014.

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Last updated: 09/20/2015
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