Melpo Christofidou-Solomidou

faculty photo
Research Associate Professor of Medicine
Director, Pulmonary Morphology Core Laboratory, University of Pennsylvania School of Medicine, Philadelphia, PA
Investigator, Center for Excellence in Environmental Toxicology (CEET), University of Pennsylvania
Investigator, Abramson Cancer Center, University of Pennsylvania
Adjunct Faculty, Institute for Environmental Medicine (IFEM), University of Pennsylvania
Founder and Chair of the Scientific Advisory Board, LignaMed, LLC, an Upstart company in collaboration with the Penn Center for Innovation (PCI) of the University of Pennsylvania
Department: Medicine

Contact information
University of Pennsylvania, Department of Medicine
Pulmonary, Allergy and Critical Care Division
3615 Civic Center Boulevard
Abramson Research Center, Office Suite 1016C
Philadelphia, PA 19104-6160
Office: (215) 573-9917
Fax: (215) 573-4469
B.S. (Biology)
State University of New York at Stony Brook, Long Island, New York, 1983.
M.S. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1987.
Ph.D. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1991.
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Description of Research Expertise

The theme of Dr. Christofidou-Solomidou's research is pulmonary inflammation and cell adhesion molecule regulation/expression. Projects involve the development of oxidant-induced acute and chronic lung injury animal models for the study of diseases such as ARDS, sepsis, radiation induced pneumonitis/fibrosis, and oxygen toxicity. Specific projects focus on the development of antioxidant methodologies such as immune conjugates for the targeting of anti-oxidant enzymes such as Catalase and Superoxide Dismutase to the pulmonary endothelium using antibodies to endothelial antigens. Recent work extends to the use of dietary alternative antioxidant agents such as curcumin, flaxseed or phenolic compounds in ameliorating acute and chronic oxidative lung disease.

Description of Itmat Expertise

Dr. Christofidou-Solomidou studies pulmonary inflammation, cell adhesion molecule regulation/ expression and acute/chronic lung injury.

Selected Publications

Yuwaraj Kadariya, Craig W. Menges, Jacqueline Talarchek, Qi Cai, Andres J. Klein-Szanto, Ralph Pietrofesa Christofidou-Solomidou M, Mitchell Cheung, Brooke T. Mossman, Arti Shukla, and Joseph R. Testa: Inflammation-related IL-1/IL-1R Signaling promotes the development of Asbestos-Induced Malignant Mesothelioma. Cancer Prevention Research In Press, March 2016.

Pietrofesa RA, Velalopoulou A, Albelda SM, and Christofidou-Solomidou M: Asbestos Induces Oxidative Stress and Activation of Nrf2 Signaling in Murine Macrophages: Chemopreventive Role of the Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605). International Journal of Molecular Sciences In Press, February 2016.

Shireen Chikara, Kaitlin Lindsey, Harsharan Dhillon, Sujan Mamidi, Jeffrey Kittilson, Christofidou-Solomidou M, and Katie M. Reindl: Enterolactone induces G1-phase cell cycle arrest in non-small cell lung cancer cells. Journal of Nutrition In Review 2016.

Salamatipour A, Mohanty SK, Pietrofesa RA, Vann D, Christofidou-Solomidou M, and Willenbring JK: Effect of grinding conditions on toxicity and mineralogical properties of chrysotile asbestos. Toxicology In Review, 2016.

Om P. Mishra, Anatoliy V. Popov, Ralph Pietrofesa and Christofidou- Solomidou M: Secoisolariciresinol Diglucoside (SDG) Scavenges Hypochlorite Ions: A Novel Mechanism of SDG Protection of Genomic DNA from Radiation. International Journal of Radiation Oncology, Biology, Physics In Review 2016.

Pietrofesa RA, Velalopoulou A, Menges CW, Testa JR, Hwang WT, Albelda SM, and Christofidou-Solomidou M: Flaxseed Lignans Enriched in Secoisolariciresinol Diglucoside (SDG) Prevent Incidence of Mesothelioma in a Murine Model of Accelerated Asbestos-Induced Mesothelioma. Carcinogenesis In Prep, 2016.

Ralph A. Pietrofesa, Anastasia Velalopoulou, Evguenia Arguiri, Raymond Luke, Om P. Mishra, Wei-Ting-Whang, Steven M. Albelda and Melpo Christofidou-Solomidou: The Flaxseed Lignan Secoisolariciresinol Diglucoside (SDG) Inhibit Asbestos-Induced Inflammasome activation. Cancer Prevention Research In Review, 2016.

Makan Khoshnejad, Vladimir V. Shuvaev, Katherine W. Pulsipher, Chuanyun Dai, Elizabeth D. Hood, Evguenia Arguiri, Melpo Christofidou-Solomidou, Ivan J. Dmochowski, Colin F. Greineder and Vladimir R. Muzykantov: Endothelial Targeting of Ferritin Nanoparticles Unveils Nano-scale Differences in Vascular Accessibility of Cell Adhesion Molecules PECAM-1 and ICAM-1. ACS Nano In Review 2016.

Vladimir V. Shuvaev, Silvia Muro, Evguenia Arguiri3 Makan Khoshnejad, Samira Tliba, Melpo Christofidou-Solomidou, and Vladimir R. Muzykantov: Size, Shape and Selection of Target Molecule Modulate Endothelial Targeting, Uptake and Anti-inflammatory Effect of Antibody-SOD Conjugate. Bioconjugate Chemistry In Press, Dec 2015.

Anastasia Velalopoulou, Sonia Tyagi, Ralph A Pietrofesa, Evguenia Arguiri, Christofidou-Solomidou M: The Flaxseed-derived Lignan Phenolic Secoisolariciresinol Diglucoside (SDG) Protects Non-Malignant Lung Cells from Radiation Damage. International Journal of Molecular Sciences In Press, Dec 22 2015.

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Last updated: 03/07/2016
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