Anil Vachani

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Associate Professor of Medicine at the Hospital of the University of Pennsylvania and the Veteran's Administration Medical Center
Attending Physician, Philadelphia Veterans Administration Medical Center
Contributor, Ask-the-Experts Board, Oncolink, University of Pennsylvania Health System
Director of Clinical Research, Section of Interventional Pulmonology and Thoracic Oncology, Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine
Director of Bronchoscopy, Philadelphia VA Medical Center
Director, Lung Nodule Program, Perelman School of Medicine, Univeristy of Pennsylvania
Associate Director, Masters in Translational Research Program, ITMAT Educational Programs
Department: Medicine

Contact information
Pulmonary, Allergy, and Critical Care Division
University of Pennsylvania School of Medicine
CHOP/Abramson Research Center, Room 1016E
3615 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215.573.7931
Fax: 215.573.4469
B.S. (Genetics)
University of California, Berkeley, 1992.
B.A. (Economics)
University of California, Berkeley, 1992.
M.D. (Medicine)
University of California, San Francisco, 1996.
M.S. (Clinical Epidemiology)
University of Pennsylvania, Perelman School of Medicine, 2013.
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Description of Itmat Expertise

Dr. Vachani is interested in the molecular epidemiology of lung cancer and in discovery and validation of early detection biomarkers for thoracic malignancies. His research ranges from animal models to human translational studies and includes observational and correlative studies in early and late phase clinical trials.

Selected Publications

Brady A.K., McNeill J.D., Judy B., Bauml J., Evans T.L., Cohen R.C., Langer C., Vachani A., Aggarwal C.: Survival outcome according to KRAS mutation status in newly diagnosed patients with stage IV non-small cell lung cancer treated with platinum doublet chemotherapy. Oncotarget 6(30): 30287-94, Oct 2015.

Paulson E.C., Veenstra C.M., Vachani A., Ciunci C.A., Epstein A.J.: Trends in surveillance for resected colorectal cancer – 2001-2009. Cancer 121(19): 3525-33, June 2015.

Vachani A.*, Silvestri G.A.*, Whitney D., Elashoff M., Porta-Smith K., Ferguson J.S., Parsons E., Mitra N., Brody J., Lenburg M.E., Spira A.: A bronchial genomic classifier for the diagnostic evaluation of lung cancer. New England Journal of Medicine Page: [epub ahead of print] May 2015.

Whitney D., Elasoff M., Porta K., Gower A., Vachani A., Ferguson J.S., Brody J., Lenburg M., Spira A. : Derivation of a gene-expression classifier in a prospective study of patients undergoing bronchoscopy for suspicion of lung cancer. BMC Medical Genomics 8(1): 18, May 2015.

Vachani A., Pass H.I., Rom W.N., Midthun D.E., Edell E.S., Laviolette M., Li X.J., Fong P.Y., Hunsucker S.W., Hayward C., Mazzone P.J., Madtes D.K., Miller Y.E., Walker M.G., Shi J., Kearney P., Fang K.C., Massion P.P. : Validation of a Multi-Protein Plasma Classifier to Identify Benign Lung Nodules Journal of Thoracic Oncology 10(4): 629-37, Apr 2015.

Wang Q., Rangiah K., Mesaros C., Snyder N.W., Vachani A., Song H., Blair I.A.: Ultrasensitive quantification of serum estrogens in postmenopausal women and older men by liquid chromatography-tandem mass spectrometry. Steroids 96: 140-52, Apr 2015.

Vachani A., Tanner N.T., Aggarwal J., Mathews C., Kearney P., Fang K.C., Silvestri G., Diette G.B.: Factors That Influence Physician Decision-making for Indeterminate Pulmonary Nodules. Annals of the American Thoracic Society 11(10): 1586-1591, Dec 2014.

Eruslanov E.B., Bhojnagarwala P.S., Quatromoni J.G., Stephen T.L., Ranganathan A., Deshpande C., Akimova T., Vachani A., Litzky L., Hancock W.W., Conejo-Garcia J.R., Feldman M., Albelda S.M., Singhal S.: Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer. The Journal of Clinical Investigation 124(12): 5466-80, Dec 2014.

Mazzone P.J., Vachani A., Chang A., Detterbeck F., Cooke D., Howington J., Dodi A., Arenberg D.: Quality Indicators for the Evaluation of Patients with Lung Cancer. Chest 146(3): 659-69, Sep 2014.

Wu Y., Kwak K.J., Agarwal K., Marras A., Wang C., Mao Y., Huang X., Ma J., Yu B., Lee R., Vachani A., Marcucci G., Byrd J.C., Muthusamy N., Otterson G. Huang K. Castro C.E., Paulaitis M., Nana-Sinkam S.P., Lee L.J.: Detection of Extracellular RNAs in Cancer and Viral Infection via Tethered Cationic Lipoplex Nanoparticles Containing Molecular Beacons. Analytical Chemistry 85(23): 11265-74, Dec 2013.

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Last updated: 11/17/2015
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