Anil Vachani

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Associate Professor of Medicine at the Hospital of the University of Pennsylvania and the Veteran's Administration Medical Center
Attending Physician, Philadelphia Veterans Administration Medical Center
Director of Clinical Research, Section of Interventional Pulmonology and Thoracic Oncology, Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine
Director of Bronchoscopy, Philadelphia VA Medical Center
Director, Lung Nodule Program, Perelman School of Medicine, Univeristy of Pennsylvania
Associate Director, Masters in Translational Research Program, ITMAT Educational Programs
Co-Director Lung Cancer Screening Program, Perelman School of Medicine, University of Pennslvania
Department: Medicine

Contact information
Pulmonary, Allergy, and Critical Care Division
University of Pennsylvania School of Medicine
Suite 216, Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104
Office: 215.573.7931
Education:
B.A. (Economics)
University of California, Berkeley, 1992.
B.S. (Genetics)
University of California, Berkeley, 1992.
M.D. (Medicine)
University of California, San Francisco, 1996.
M.S. (Clinical Epidemiology)
University of Pennsylvania, Perelman School of Medicine, 2013.
Post-Graduate Training
Categorical Internal Medicine Residency Program, Hospital of the University of Pennsylvania, Department of Medicine , 1996-1999.
Fellowship, Pulmonary and Critical Care Medicine, Hospital of the University of Pennsylvania, Department of Medicine, 2000-2004.
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Description of Itmat Expertise

Dr. Vachani is interested in the molecular epidemiology of lung cancer and in discovery and validation of early detection biomarkers for thoracic malignancies. His research ranges from animal models to human translational studies and includes observational and correlative studies in early and late phase clinical trials.

Selected Publications

Rendle KA, Burnett-Hartman AN, Neslund-Dudas C, Greenlee RT, Honda S, Elston Lafata J, Marcus PM, Cooley ME, Vachani A, Meza R, Oshiro C, Simoff MJ, Schnall MD, Beaber EF, Doria-Rose VP, Doubeni CA, Ritzwoller DP: Evaluating Lung Cancer Screening Across Diverse Healthcare Systems: A Process Model from the Lung PROSPR Consortium. Cancer Prev Res Feb 2020.

Silvestri GA, Bevill BT, Huang J, Brooks M, Choi Y, Kennedy G, Lofaro L, Chen A, Rivera MP, Tanner NT, Vachani A, Yarmus L, Pastis NJ: An evaluation of diagnostic yield from Bronchoscopy: the impact of clinical/radiographic factors, procedure type and degree of suspicion for cancer. Chest Jan 2020.

Yarmus L, Akulian J, Wahidi M, Chen A, Steltz JP, Solomon SL, Yu D, Maldonado F, Cardenas-Garcia J, Molena D, Lee H, Vachani A: A Prospective Randomized Comparative Study of Three Guided Bronchoscopic Approaches for Investigating Pulmonary Nodules: The PRECISION-1 Study. Chest November 2019 (epub ahead of print).

Bagley SJ, Talento S, Mitra N, Meropol NJ, Cohen RB, Langer CJ, Vachani A: Comparative Effectiveness of Carboplatin-Pemetrexed With vs Without Bevacizumab in Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer. Journal of the National Comprehensive Cancer Network 15(5): 469-477, May 2019.

Kossenkov AV, Qureshi R, Dawany NB, Wickramasinghe J, Liu Q, Majumdar RS, Chang C, Widura S, Kumar T, Horng WH, Konnisto E, Criner G, Tsay JJ, Pass H, Yendamuri S, Vachani A, Bauer T, Nam B, Rom WN, Showe MK, Showe LC: A Gene Expression Classifier from Whole Blood Distinguishes Benign from Malignant Lung Nodules Detected by Low-Dose CT. Cancer Research 79(1): 263-73, Jan 2019.

Thompson JC, Fan R, Black T, Yu GH, Savitch SL, Chien A, Yee SS, Sen M, Hwang WT, Katz SI, Feldman M, Vachani A, Carpenter EL. : Measurement and immunophenotyping of pleural fluid EpCAM-positive cells and clusters for the management of non-small cell lung cancer patients. Lung Cancer 127: 25-33, Jan 2019.

Weng L, Guo L, Vachani A, Mesaros C, Blair IA.: Quantification of Serum High Mobility Group Box 1 by Liquid Chromatography/High-Resolution Mass Spectrometry: Implications for Its Role in Immunity, Inflammation, and Cancer. Anal Chem 90(12): 7552-7560, Jun 2018.

Silvestri GA, Tanner NT, Kearney P, Vachani A, Massion PP, Porter A, Springmeyer SC, Fang KC, Midthun D, Mazzone PJ; PANOPTIC Trial Team: Assessment of Plasma Proteomics Biomarker's Ability to Distinguish Benign From Malignant Lung Nodules: Results of the PANOPTIC (Pulmonary Nodule Plasma Proteomic Classifier) Trial. Chest March 2018.

Morris S, Vachani A, Pass HI, Rom WN, Ryden K, Weiss GJ, Hogarth DK, Runger G, Richards D, Shelton T, Mallery DW: Whole blood FPR1 mRNA expression predicts both non-small cell and small cell lung cancer. Int J Cancer Jan 2018.

Huang J., Liu Y., Vitale S., Penning T.M., Whitehead A.S., Blair I.A., Vachani A., Clapper M., Muscat J.E., Lazarus P., Scheet P., Moore J.H., Chen Y.: On meta- and mega-analyses for gene–environment interactions. Genetic Epidemiology November 2017.

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Last updated: 08/08/2020
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