Donald M. O'Rourke

faculty photo
John Templeton, Jr., M.D. Associate Professor in Neurosurgery
Faculty , Abramson Family Cancer Center, Cell and Development Biology Program, Translational Studies Program, University of Pennsylvania
Founding Member, Center for Cancer Pharmacology, University of Pennsylvania
Director, Human Brain Tissue Bank, University of Pennsylvania
Faculty Member, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania
Full Member, Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania
Founding Member, Philadelphia Coalition for a Cure (PC4C), The Children's Hospital of Philadelphia, University of Pennsylvania
Mack Technology Fellow, Mack Institute for Innovation Management, The Wharton School, University of Pennsylvania, University of Pennsylvania
Faculty, Penn Center for Cellular Immunotherapies
Department: Neurosurgery

Contact information
HUP - 3 Silverstein
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3490
Fax: 215-349-5534
A.B. (Biochemistry and Molecular Biology)
Harvard University (Magna Cum Laude), 1983.
M.D. (Medicine)
University of Pennsylvania, 1987.
M.A. (Arts)
University of Pennsylvania, 2002.
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Description of Itmat Expertise

EGFR signaling and novel therapeutics and imaging in glioblastoma

Selected Publications

Liu T, Ma W, Xu H, Huang M, Zhang D, He Z, Zhang L, Brem S, O'Rourke DM, Gong Y, Mou Y, Zhang Z, Fan Y: PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma. Nature Communications 9(1), August 2018.

Yin Y, Boesteanu, AC, Binder, ZA, Xu C, Reid RA, Rodriguez J L, Cook DR; Thokala, R, Blouch, K McGettigan-Croce B, Zhang L, Konradt Christoph, Cogdill, AP, Panjwani, MK; Jiang S, Migliorini, D, Dahmane N, Posey Jr, AD; June CH, Mason NJ, Lin, Z, Johnson, LA, O’Rourke, DM: Checkpoint blockade reverses anergy in IL13Rα2 humanized scFv based CAR T cells to treat murine and canine gliomas. Molecular Therapy-Oncolytics August 2018.

Binder ZA, Thorne AH, Bakas S, Wileyto EP, Bilello M, Akbari H, Rathore S, Ha SM, Zhang L, Ferguson C, Dahiya S, Bi WL, Reardon DA, Idbaih A, Felsberg J, Hentschel B, Weller M, Bagley SJ, Morrissette JJD, Nasrallah MP, Ma J, Orellana L, Scott AM, Davatzikos C, Furnari FB, O'Rourke DM.: Epidermal Growth Factor Receptor extracellular domain mutations in glioblastoma present opportunities for clinical imaging and therapeutic development. Cancer Cell 34(1): 163-177.e7, July 2018 Notes: DOI: 10.1016/j.ccell.2018.06.006.

Chawla S, Wang S, Mohan S, Nasrallah M, Verma G, Brem S, O'Rourke DM, Wolf RL, Poptani H, Nabavizadeh SA.: Differentiation of brain infection from necrotic glioblastoma using combined analysis of diffusion and perfusion MRI. J Magn Reson Imaging April 2018 Notes: [Epub ahead of print] doi: 10.1002/jmri.26053.

Rathore S, Akbari H, Rozycki M, Abdullah KG, Nasrallah MP, Binder ZA, Davuluri RV, Lustig RA, Dahmane N, Bilello M, O'Rourke DM, Davatzikos C: Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics offering prognostic value beyond IDH1. Sci Reports 8(1): 5087, March 2018.

Akbari H, Bakas S, Pisapia JM, Nasrallah MP, Rozycki M, Martinez-Lage M, Morrissette JJD, Dahmane N, O'Rourke DM, Davatzikos C: In vivo evaluation of EGFRvIII mutation in primary glioblastoma patients via complex multiparametric MRI signature. Neuro Oncol March 2018 Notes: [Epub ahead of Print] - DOI: 10.1093/neuonc/noy033.

Wang Q, He Z, Huang M, Liu Y, Wang Y, Xu H, Duan H, Ma P, Zhang L, Zamvil SS, Hidalgo J, Zhang Z, O'Rourke DM, Dahmane N, Brem S, Mou Y, Gong Y, Fan Y: Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2a. Nature Communications 9(1): 559, Feb 2018.

Morris J, NA YJ, Zhu H, Lee JH, Giang H, Ulyanova AV, Baltuch GH, Brem S, Chen HI, Kung DK, Lucas TH, O'Rourke DM, Wolf JA, Grady MS, Sul JY, Kim J, Eberwine J.: Pervasive within-Mitochondrion Single-Nucleotide Variant Heteroplasmy as Revealed by Single-Mitochondrion Sequencing. Cell Reports 21(10): 2706-2713, Dec 2017.

Roccograndi L, Binder ZA, Zhang L, Aceta N, Zhang Z, Bentores-Alj M, Nakano, I, Dahmane N, O’Rourke DM. : Shp2 regulates proliferation and tumorigenicity of glioma stem cells. J Neurooncol 135(3): 487-496, Dec 2017.

Weller M, Butowski N, Tran DD, Recht L, Lim M, Hirte H, Ashby L, Mechtler L, Goldlust S, Iwamoto F, Drappatz J, O’Rourke DM, et al.: Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): results of a randomized, double-blind, international phase 3 trial. Lancet Oncol. 18(10): 1373-1385, Oct 2017.

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Last updated: 10/19/2018
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