Daniel J. Licht
Emeritus Professor CE of Neurology
Professor, Children's National Hospital
Department: Neurology
Contact information
Children's National Hospital
111 Michigan Ave NW
Washington, 20010
111 Michigan Ave NW
Washington, 20010
Email:
licht@email.chop.edu
licht@email.chop.edu
Publications
Links
Search PubMed for articles
ITMAT Member
CHOP Provider Profile
Lab web page with people and projects listed
Joseph Stokes Jr. Research Institute Profile
Search PubMed for articles
ITMAT Member
CHOP Provider Profile
Lab web page with people and projects listed
Joseph Stokes Jr. Research Institute Profile
Education:
BA (Biochemistry)
New York University, 1984.
MD (Medicine)
New Jersey Medical School - UMDNJ, 1997.
BA (Biochemistry)
New York University, 1984.
MD (Medicine)
New Jersey Medical School - UMDNJ, 1997.
Post-Graduate Training
House officer, The Children's Hospital of Philadelphia, 1997-1999.
Neurology fellow, Hospital of the University of Pennsylvania, The Children's Hospital of Philadelphia, 1999-2002.
Epilepsy and Critical Care Fellowship, The Children's Hospital of Philadelphia, 2002-2004.
Permanent linkHouse officer, The Children's Hospital of Philadelphia, 1997-1999.
Neurology fellow, Hospital of the University of Pennsylvania, The Children's Hospital of Philadelphia, 1999-2002.
Epilepsy and Critical Care Fellowship, The Children's Hospital of Philadelphia, 2002-2004.
Description of Research Expertise
I am a child neurologist with expertise in the care of the critically ill infants and children. My clinical practice informs my research endeavors as I try to understand how the delivery of care affects cerebral blood flow and brain metabolic use of oxygen. My research uses non-invasive imaging techniques, including MRI and Optics, which, when combined, offer both high anatomic resolution and time sensitivity.As a consequence of my research in infants with severe congenital heart defects, I have begun exploring fetal research. I have developed an MRI technique to qualitatively assess fetal brain development as a tool to monitor fetal brain health. This is now being used to monitor a drug trial for a neuroprotective agent for fetuses identified with severe congenital heart defects. I am currently leading research to non-invasively image placental anatomy and function.
Description of Itmat Expertise
Dr. Licht is a pediatric neurologist who is interested in implementing innovative, non-invasive neuro-imaging techniques for clinical use. Current research involves the study of the influence of congenital heart defects on fetal brain development.Selected Publications
Matlis GC, Zhang Q, Benson EJ, Weeks MK, Andersen K, Jahnavi J, Lafontant A, Breimann J, Hallowell T, Lin Y, Licht DJ, Yodh AG, Kilbaugh TJ, Forti RM, White BR, Baker WB, Xiao R, Ko TS.: Chassis-based fiber-coupled optical probe design for reproducible quantitative diffuse optical spectroscopy measurements. PLoS One 19: e0305254, Jul 2024.Agarwal D, Hunt ML, Sridharan A, Larson AC, Rychik J, Licht DJ, Davey MG, Flake AW, Gaynor JW, Didier RA.: Unique model of chronic hypoxia in fetal lambs demonstrates abnormal contrast-enhanced ultrasound brain perfusion. Pediatr Res Jun 2024.
Gaynor JW, Moldenhauer JS, Zullo EE, Burnham NB, Gerdes M, Bernbaum JC, D'Agostino JA, Linn RL, Klepczynski B, Randazzo I, Gionet G, Choi GH, Karaj A, Russell WW, Zackai EH, Johnson MP, Gebb JS, Soni S, DeBari SE, Szwast AL, Ahrens-Nicklas RC, Drivas TG, Jacobwitz M, Licht DJ, Vossough A, Nicolson SC, Spray TL, Rychik J, Putt ME.: Progesterone for Neurodevelopment in Fetuses With Congenital Heart Defects: A Randomized Clinical Trial. JAMA Netw Open 7: e2412291, May 2024.
Aronowitz DI, Geoffrion TR, Piel S, Morton SR, Starr J, Melchior RW, Gaudio HA, Degani R, Widmann NJ, Weeks MK, Ranieri NR, Benson E, Ko TS, Licht DJ, Hefti M, Gaynor JW, Kilbaugh TJ, Mavroudis CD.: Normoxic Management during Cardiopulmonary Bypass Does Not Reduce Cerebral Mitochondrial Dysfunction in Neonatal Swine. Int J Mol Sci 25: 5466, May 2024.
Lee VK, Ceschin R, Reynolds WT, Meyers B, Wallace J, Landsittel D, Joseph HM, Badaly D, Gaynor JW, Licht D, Greene NH, Brady KM, Hunter JV, Chu ZD, Wilde EA, Easley RB, Andropoulos D, Panigrahy A.: Postnatal Brain Trajectories and Maternal Intelligence Predict Childhood Outcomes in Complex CHD. J Clin Med 13: 2922, May 2024.
Aronowitz DI, Geoffrion TR, Piel S, Benson EJ, Morton SR, Starr J, Melchior RW, Gaudio HA, Degani RE, Widmann NJ, Weeks MK, Ko TS, Licht DJ, Hefti M, Gaynor JW, Kilbaugh TJ, Mavroudis CD.: Early Impairment of Cerebral Bioenergetics After Cardiopulmonary Bypass in Neonatal Swine. World J Pediatr Congenit Heart Surg Apr 2024.
Reitz JG, Zurakowski D, Kuhn VA, Murnick J, Donofrio MT, d'Udekem Y, Licht D, Kosiorek A, Limperopoulos C, Axt-Fliedner R, Yerebakan C, Carpenter JL.: Brain injury and neurodevelopmental outcomes in children undergoing surgery for congenital heart disease. JTCVS Open 17: 229-247, Dec 2023.
Andersen KN, Yao S, White BR, Jacobwitz M, Breimann J, Jahnavi J, Schmidt A, Baker WB, Ko TS, Gaynor JW, Vossough A, Xiao R, Licht DJ, Shih EK.: Cerebral microhemorrhages in children with congenital heart disease: Prevalence, risk factors, and impact on neurodevelopmental outcomes. medRxiv Dec 2023.
Benson EJ, Aronowitz DI, Forti RM, Lafontant A, Ranieri NR, Starr JP, Melchior RW, Lewis A, Jahnavi J, Breimann J, Yun B, Laurent GH, Lynch JM, White BR, Gaynor JW, Licht DJ, Yodh AG, Kilbaugh TJ, Mavroudis CD, Baker WB, Ko TS.: Diffuse Optical Monitoring of Cerebral Hemodynamics and Oxygen Metabolism during and after Cardiopulmonary Bypass: Hematocrit Correction and Neurological Vulnerability. Metabolites 13: 1153, Nov 2023.
Hsia J, Abend NS, Gaynor JW, Chen JM, Fuller S, Maeda K, Mavroudis CD, Nuri M, Leonard J, Ampah SB, Licht DJ, Massey SL, Naim MY.: Incidence of postoperative seizures in neonates following cardiac surgery with regional cerebral perfusion and deep hypothermic circulatory arrest. JTCVS Open 16: 771-783, Oct 2023.