Daniel J. Licht

faculty photo
Emeritus Professor CE of Neurology
Professor, Children's National Hospital
Department: Neurology

Contact information
Children's National Hospital
111 Michigan Ave NW
Washington, 20010
BA (Biochemistry)
New York University, 1984.
MD (Medicine)
New Jersey Medical School - UMDNJ, 1997.
Post-Graduate Training
House officer, The Children's Hospital of Philadelphia, 1997-1999.
Neurology fellow, Hospital of the University of Pennsylvania, The Children's Hospital of Philadelphia, 1999-2002.
Epilepsy and Critical Care Fellowship, The Children's Hospital of Philadelphia, 2002-2004.
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Description of Research Expertise

I am a child neurologist with expertise in the care of the critically ill infants and children. My clinical practice informs my research endeavors as I try to understand how the delivery of care affects cerebral blood flow and brain metabolic use of oxygen. My research uses non-invasive imaging techniques, including MRI and Optics, which, when combined, offer both high anatomic resolution and time sensitivity.

As a consequence of my research in infants with severe congenital heart defects, I have begun exploring fetal research. I have developed an MRI technique to qualitatively assess fetal brain development as a tool to monitor fetal brain health. This is now being used to monitor a drug trial for a neuroprotective agent for fetuses identified with severe congenital heart defects. I am currently leading research to non-invasively image placental anatomy and function.

Description of Itmat Expertise

Dr. Licht is a pediatric neurologist who is interested in implementing innovative, non-invasive neuro-imaging techniques for clinical use. Current research involves the study of the influence of congenital heart defects on fetal brain development.

Selected Publications

Benson EJ, Aronowitz DI, Forti RM, Lafontant A, Ranieri NR, Starr JP, Melchior RW, Lewis A, Jahnavi J, Breimann J, Yun B, Laurent GH, Lynch JM, White BR, Gaynor JW, Licht DJ, Yodh AG, Kilbaugh TJ, Mavroudis CD, Baker WB, Ko TS.: Diffuse Optical Monitoring of Cerebral Hemodynamics and Oxygen Metabolism during and after Cardiopulmonary Bypass: Hematocrit Correction and Neurological Vulnerability. Metabolites 13: 1153, Nov 2023.

Fogel MA, Donnelly E, Crandell I, Hanlon A, Whitehead KK, Harris M, Partington S, Biko D, Flynn T, Nicolson S, Gaynor JW, Licht D, Vossough A.: Cerebral Blood Flow, Brain Injury, and Aortic-Pulmonary Collateral Flow After the Fontan Operation. Am J Cardiol 208: 164-170, Oct 2023.

Johng S, Licht DJ, Hedrick HL, Rintoul N, Linn RL, Gebb JS, Xiao R, Massey SL.: Prenatal Brain Maturation is Delayed in Neonates with Congenital Diaphragmatic Hernia. J Pediatr 264: 113738, Sep 2023.

Jacobwitz M, Irving SY, Moriarty H, Yost J, Vossough A, Licht DJ, Lynch JM.: Predictors of the inability to achieve full oral feeding in postoperative infants with CHD. Cardiol Young Aug 2023.

Shaw K, Mavroudis CD, Ko TS, Jahnavi J, Jacobwitz M, Ranieri N, Forti RM, Melchior RW, Baker WB, Yodh AG, Licht DJ, Nicolson SC, Lynch JM.: The use of novel diffuse optical spectroscopies for improved neuromonitoring during neonatal cardiac surgery requiring antegrade cerebral perfusion. Front Pediatr 11: 1125985, Jun 2023.

Forti RM, Hobson LJ, Benson EJ, Ko TS, Ranieri NR, Laurent G, Weeks MK, Widmann NJ, Morton S, Davis AM, Sueishi T, Lin Y, Wulwick KS, Fagan N, Shin SS, Kao SH, Licht DJ, White BR, Kilbaugh TJ, Yodh AG, Baker WB.: Non-invasive diffuse optical monitoring of cerebral physiology in an adult swine-model of impact traumatic brain injury. Biomed Opt Express 14: 2432-2448, May 2023.

Licht DJ, Jacobwitz M, Lynch JM, Ko T, Boorady T, Devarajan M, Heye KN, Mensah-Brown K, Newland JJ, Schmidt A, Schwab P, Winters M, Nicolson SC, Montenegro LM, Fuller S, Mascio C, Gaynor JW, Yodh AG, Gebb J, Vossough A, Choi GH, Putt ME.: Impaired Maternal-Fetal Environment and Risk for Preoperative Focal White Matter Injury in Neonates With Complex Congenital Heart Disease. J Am Heart Assoc 12: e025516, Mar 2023.

Gaynor JW, Burnham NB, Ittenbach RF, Gerdes M, Bernbaum JC, Zackai E, Licht DJ, Russell WW, Zullo EE, Miller T, Hakonarson H, Clarke KA, Jarvik GP, Calafat AM, Bradman A, Bellinger DC, Henretig FM, Coker ES.: Childhood exposures to environmental chemicals and neurodevelopmental outcomes in congenital heart disease. PLoS One 17: e0277611, Nov 2022.

Ko TS, Mavroudis CD, Benson EJ, Forti RM, Melchior RW, Boorady TW, Morano VC, Mensah-Brown K, Lin Y, Aronowitz D, Starr JP, Rosenthal TM, Shade BC, Schiavo KL, White BR, Lynch JM, Gaynor JW, Licht DJ, Yodh AG, Baker WB, Kilbaugh TJ.: Correlation of Cerebral Microdialysis with Non-Invasive Diffuse Optical Cerebral Hemodynamic Monitoring during Deep Hypothermic Cardiopulmonary Bypass. Metabolites 12: 737, Aug 2022.

Goldman-Yassen AE, Shifrin A, Mirsky DM, Vossough A, Licht DJ, Feygin T.: Torcular Dural Sinus Malformation: Fetal and Postnatal Imaging Findings and Their Associations With Clinical Outcomes. Pediatr Neurol 135: 28-37, Jul 2022.

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Last updated: 12/06/2023
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