Daniel J Rader
Seymour Gray Professor of Molecular Medicine
Chair, Department of Genetics
Chief, Division of Translational Medicine and Human Genetics, Department of Medicine
Associate Director, Institute for Translational Medicine and Therapeutics
Co-Director, Penn Medicine BioBank
Department: Medicine
Graduate Group Affiliations
Contact information
Perelman School of Medicine
University of Pennsylvania
11-125 Smilow Center for Translational Research
3400 Civic Center Blvd
Philadelphia, PA 19104-5158
University of Pennsylvania
11-125 Smilow Center for Translational Research
3400 Civic Center Blvd
Philadelphia, PA 19104-5158
Office: (215) 573-4176
Fax: (215) 573-8606
Fax: (215) 573-8606
Email:
rader@pennmedicine.upenn.edu
rader@pennmedicine.upenn.edu
Publications
Links
Search PubMed for articles
Institute for Diabetes, Obesity and Metabolism (IDOM) - Cardiovascular Metabolism Unit
Penn Medicine Physician Profile
Institute for Translational Medicine and Therpeutics (ITMAT)
Search PubMed for articles
Institute for Diabetes, Obesity and Metabolism (IDOM) - Cardiovascular Metabolism Unit
Penn Medicine Physician Profile
Institute for Translational Medicine and Therpeutics (ITMAT)
Education:
B.A.
Lehigh University, 1981.
M.D.
Medical College of Pennsylvania, 1984.
B.A.
Lehigh University, 1981.
M.D.
Medical College of Pennsylvania, 1984.
Post-Graduate Training
Internship, Internal Medicine, Yale-New Haven Hospital, New Haven, CT, 1984-1985.
Residency, Internal Medicine, Yale-New Haven Hospital, New Haven, CT, 1985-1987.
Chief Resident, Internal Medicine, Yale School of Medicine, New Haven, CT, 1987-1988.
Medical Staff Fellow, Molecular Disease Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, 1988-1991.
Permanent linkInternship, Internal Medicine, Yale-New Haven Hospital, New Haven, CT, 1984-1985.
Residency, Internal Medicine, Yale-New Haven Hospital, New Haven, CT, 1985-1987.
Chief Resident, Internal Medicine, Yale School of Medicine, New Haven, CT, 1987-1988.
Medical Staff Fellow, Molecular Disease Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, 1988-1991.
Description of Research Expertise
Research InterestsThe Rader laboratory
Description of Itmat Expertise
Research InterestsThe Rader laboratory
Selected Publications
Vitali C, Rader DJ, Cuchel M.: Novel therapeutic opportunities for familial lecithin:cholesterol acyltransferase deficiency: promises and challenges. Curr Opin Lipidol 34: 35-43, Apr 2023.Small AM, Peloso GM, Linefsky J, Aragam J, Galloway A, Tanukonda V, Wang LC, Yu Z, Sunitha Selvaraj M, Farber-Eger EH, Baker MT, Setia-Verma S, Lee SSK, Preuss M, Ritchie MD, Damrauer SM, Rader DJ, Wells QS, Loos R, Lubitz SA, Thanassoulis G, Cho K, Wilson PWF; VA Million Veteran Program; Natarajan P, O'Donnell CJ.: Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program. Circulation 147: 942-955, Mar 2023.
Rosenson RS, Gaudet D, Ballantyne CM, Baum SJ, Bergeron J, Kershaw EE, Moriarty PM, Rubba P, Whitcomb DC, Banerjee P, Gewitz A, Gonzaga-Jauregui C, McGinniss J, Ponda MP, Pordy R, Zhao J, Rader DJ.: Evinacumab in severe hypertriglyceridemia with or without lipoprotein lipase pathway mutations: a phase 2 randomized trial. Nat Med 29(3): 729-737, Mar 2023.
Hui D, Mehrabi S, Quimby AE, Chen T, Chen S, Park J, Li B; Regeneron Genetics Center; Penn Medicine Biobank; Ruckenstein MJ, Rader DJ, Ritchie MD, Brant JA, Epstein DJ, Mathieson I.: Gene burden analysis identifies genes associated with increased risk and severity of adult-onset hearing loss in a diverse hospital-based cohort. PLoS Genet 19: e1010584, Jan 2023.
Krychtiuk KA, Rader DJ, Granger CB.: RNA-targeted therapeutics in cardiovascular disease: the time is now. Eur Heart J Cardiovasc Pharmacother 9: 94-99, Dec 2022.
Huang J, Huffman JE, Huang Y, Do Valle Í, Assimes TL, Raghavan S, Voight BF, Liu C, Barabási AL, Huang RDL, Hui Q, Nguyen XT, Ho YL, Djousse L, Lynch JA, Vujkovic M, Tcheandjieu C, Tang H, Damrauer SM, Reaven PD, Miller D, Phillips LS, Ng MCY, Graff M, Haiman CA, Loos RJF, North KE, Yengo L, Smith GD, Saleheen D, Gaziano JM, Rader DJ, Tsao PS, Cho K, Chang KM, Wilson PWF; VA Million Veteran Program; Sun YV, O'Donnell CJ.: Genomics and phenomics of body mass index reveals a complex disease network. Nat Commun 13: 7973, Dec 2022.
Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF, Vedantam S, Winkler TW, Locke AE, Marouli E, Zajac GJM, Wu KH, Ntalla I, Hui Q, Klarin D, Hilliard AT, Wang Z, Xue C, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, Hwang MY, Han S, Akiyama M, Sakaue S, Terao C, Kanai M, Zhou W, Brumpton BM, Rasheed H, Havulinna AS, Veturi Y, Pacheco JA, Rosenthal EA, Lingren T, Feng Q, Kullo IJ, Narita A, Takayama J, Martin HC, Hunt KA, Trivedi B, Haessler J, Giulianini F, Bradford Y, Miller JE, Campbell A, Lin K, Millwood IY, Rasheed A, Hindy G, Faul JD, Zhao W, Weir DR, Turman C, Huang H, Graff M, Choudhury A, Sengupta D, Mahajan A, Brown MR, Zhang W, Yu K, Schmidt EM, Pandit A, Gustafsson S, Yin X, Luan J, Zhao JH, Matsuda F, Jang HM, Yoon K, Medina-Gomez C, Pitsillides A, Hottenga JJ, Wood AR, Ji Y, Gao Z, Haworth S, Yousri NA, Mitchell RE, Chai JF, Aadahl M, Bjerregaard AA, Yao J, Manichaikul A, Hwu CM, Hung YJ, Warren HR, Ramirez J, Bork-Jensen J, Kårhus LL, Goel A, Sabater-Lleal M, Noordam R, Mauro P, et al.: Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. Genome Biol 23: 268, Dec 2022.
Ko YA, Billheimer JT, Lyssenko NN, Kueider-Paisley A, Wolk DA, Arnold SE, Leung YY, Shaw LM, Trojanowski JQ, Kaddurah-Daouk RF, Kling MA, Rader DJ.: ApoJ/Clusterin concentrations are determinants of cerebrospinal fluid cholesterol efflux capacity and reduced levels are associated with Alzheimer's disease. Alzheimers Res Ther 14: 194, Dec 2022.
Park J, MacLean MT, Lucas AM, Torigian DA, Schneider CV, Cherlin T, Xiao B, Miller JE, Bradford Y, Judy RL; Regeneron Genetics Center; Verma A, Damrauer SM, Ritchie MD, Witschey WR, Rader DJ.: Exome-wide association analysis of CT imaging-derived hepatic fat in a medical biobank. Cell Rep Med 3: 100855, Dec 2022.
Taylor SC, Gehringer BN, Dow HC, Langer A, Rawot E, Smernoff Z, Steeman S, Almasy L, Rader DJ, Bučan M, Brodkin ES.: Contrasting Views of Autism Spectrum Traits in Adults, Especially in Self-Reports vs. Informant-Reports for Women High in Autism Spectrum Traits. J Autism Dev Disord Dec 2022.