Ravinder Reddy

faculty photo
Professor of Radiology
Department: Radiology
Graduate Group Affiliations

Contact information
B1 Stellar-Chance Laboratories
422 Curie Blvd.
Philadelphia, PA 19104-6100
Office: (215) 898-5708
Fax: (215) 573-2113
Lab: (215) 898-9357
Education:
B.Sc. (Math, Physics, and Chemistry)
Osmania University , 1979.
M.Sc. (Chemistry)
Kakatiya University , 1982.
Ph.D. (Chemistry)
Indian Institute of Technology, Kanpur, 1989.
Post-Graduate Training
Research Assistant, Indian Institute of Technology, 1988-1989.
Post Doctoral Fellow, University of Pennsylvania, 1989-1991.
Research Associate, University of Pennsylvania, 1991-1993.
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Description of Research Expertise

My research interests are in developing novel, multinuclear (23Na, 17O, 13C and 1H) magnetic resonance imaging and spectroscopic techniques for the early diagnosis and quantification of physiological and functional aberrations in pathologies such as arthritis, stroke, cancer and Alzheimer’s disease. Our pulse sequence developmental approaches exploit quadrupolar spin-dynamics, polarization transfer, multiple quantum coherences, indirect detection via chemical exchange and spin-locking T1ρ MRI for studying molecular dynamics in biological tissues in vivo.

Specifically, T1ρ and Sodium MRI techniques are designed to map proteoglycan molecules (e.g. aggrecan) in cartilage as a biomarker for early arthritis in vivo. T1ρ MRI is also targeted to impart novel contrast in various tissue types (brain, connective tissues and tumors), and to detect metabolically produced H217O for studying cerebral blood flow and cerebral oxidative metabolism.

Recent developmental work on chemical exchange saturation transfer (CEST) based MRI methods is focused on measuring endogenous but low concentration metabolites in the brain, such as glutamate, myoinositol and creatine to address central nervous system disorders. In addition, a creatine CEST method is currently being explored to measure high-energy phosphate metabolism in the myocardium in heart disease.

Description of Itmat Expertise

Dr. Reddy's research include developing novel, multinuclear (23Na, 17O, 13C and 1H) magnetic resonance imaging and spectroscopic techniques for early diagnosis and quantification of physiological and functional parameters in pathologies such as arthritis, stroke, cancer and Alzheimer's disease.

Selected Publications

Li Y, Xie D, Cember A, Nanga RPR, Yang H, Kumar D, Hariharan H, Bai L, Detre JA, Reddy R, Wang Z.: Accelerating GluCEST imaging using deep learning for B0 correction Magn Reson Med. 84((4)): 1724, October 2020.

Zelenski N, Falk DP, D'Aquilla K, Borthakur A, Bannister E, Kneeland B, Reddy R, Zgonis M.: Zone- and layer-specific differences in proteoglycan content in patellofemoral pain syndrome are detectable on T1ρ MRI Skeletal Radiol. 49((9)): 1397, Sept 2020.

Kumar D, Nanga RPR, Thakuri D, Wilson N, Cember A, Martin ML, Zhu D, Shinohara RT, Qin Q, Hariharan H, Reddy R.: Recovery kinetics of creatine in mild plantar flexion exercise using 3D creatine CEST imaging at 7 Tesla Magn Reson Med. Aug 2020.

Hashem S, Nisar S, Bhat AA, Yadav SK, Azeem MW, Bagga P, Fakhro K, Reddy R, Frenneaux MP, Haris M.: Genetics of structural and functional brain changes in autism spectrum disorder Transl Psychiatry. 10((1)): 229, July 2020.

Roalf DR, Sydnor VJ, Woods M, Wolk DA, Scott JC, Reddy R, Moberg PJ.: A quantitative meta-analysis of brain glutamate metabolites in aging Neurobiol Aging. 95: 240, July 2020.

Nisar S, Bhat AA, Hashem S, Syed N, Yadav SK, Uddin S, Fakhro K, Bagga P, Thompson P, Reddy R, Frenneaux MP, Haris M.: Genetic and Neuroimaging Approaches to Understanding Post-Traumatic Stress Disorder Int J Mol Sci. 21((12)): 4503, June 2020.

Bhat AA, Syed N, Therachiyil L, Nisar S, Hashem S, Macha MA, Yadav SK, Krishnankutty R, Muralitharan S, Al-Naemi H, Bagga P, Reddy R, Dhawan P, Akobeng A, Uddin S, Frenneaux MP, El-Rifai W, Haris M.: Claudin-1, A Double-Edged Sword in Cancer Int J Mol Sci. 21((2)): 569, January 2020.

Debnath A, Hariharan H, Nanga RPR, Reddy R, Singh A: Glutamate-Weighted CEST Contrast After Removal of Magnetization Transfer Effect in Human Brain and Rat Brain with Tumor. Mol Imaging Biol 4: 1087, January 2020.

Bhat AA, Syed N, Therachiyil L, Nisar S, Hashem S, Macha MA, Yadav SK, Krishnankutty R, Muralitharan S, Al-Naemi H, Bagga P, Reddy R, Dhawan P, Akobeng A, Uddin S, Frenneaux MP, El-Rifai W, Haris M, Claudin-1: A Double-Edged Sword in Cancer. Int J Mol Sci 21((2)), January 2020.

Laurie R, Bagga P, Wilson NE, Schnall MD, Detre JA, Haris M, Reddy R: 1H magnetic resonance spectroscopy of 2H-to-1H exchange quantifies the dynamics of cellular metabolism in vivo. Nat. Biomed. Eng. 4((3)): 335, January 2020.

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Last updated: 11/11/2020
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