Ravinder Reddy

faculty photo
Professor of Radiology
Department: Radiology

Contact information
B1 Stellar-Chance Laboratories
422 Curie Blvd.
Philadelphia, PA 19104-6100
Office: (215) 898-5708
Fax: (215) 573-2113
Lab: (215) 898-9357
Education:
B.Sc. (Math, Physics, and Chemistry)
Osmania University , 1979.
M.Sc. (Chemistry)
Kakatiya University , 1982.
Ph.D. (Chemistry)
Indian Institute of Technology, Kanpur, 1989.
Post-Graduate Training
Research Assistant, Indian Institute of Technology, 1988-1989.
Post Doctoral Fellow, University of Pennsylvania, 1989-1991.
Research Associate, University of Pennsylvania, 1991-1993.
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Description of Research Expertise

My research interests are in developing novel, multinuclear (23Na, 17O, 13C and 1H) magnetic resonance imaging and spectroscopic techniques for the early diagnosis and quantification of physiological and functional aberrations in pathologies such as arthritis, stroke, cancer and Alzheimer’s disease. Our pulse sequence developmental approaches exploit quadrupolar spin-dynamics, polarization transfer, multiple quantum coherences, indirect detection via chemical exchange and spin-locking T1ρ MRI for studying molecular dynamics in biological tissues in vivo.

Specifically, T1ρ and Sodium MRI techniques are designed to map proteoglycan molecules (e.g. aggrecan) in cartilage as a biomarker for early arthritis in vivo. T1ρ MRI is also targeted to impart novel contrast in various tissue types (brain, connective tissues and tumors), and to detect metabolically produced H217O for studying cerebral blood flow and cerebral oxidative metabolism.

Recent developmental work on chemical exchange saturation transfer (CEST) based MRI methods is focused on measuring endogenous but low concentration metabolites in the brain, such as glutamate, myoinositol and creatine to address central nervous system disorders. In addition, a creatine CEST method is currently being explored to measure high-energy phosphate metabolism in the myocardium in heart disease.

Description of Itmat Expertise

Dr. Reddy's research include developing novel, multinuclear (23Na, 17O, 13C and 1H) magnetic resonance imaging and spectroscopic techniques for early diagnosis and quantification of physiological and functional parameters in pathologies such as arthritis, stroke, cancer and Alzheimer's disease.

Selected Publications

Cember ATJ, Deck BL, Kelkar A, Faseyitan O, Zimmerman JP, Erickson B, Elliott MA, Coslett HB, Hamilton RH, Reddy R, Madaglia JD. : Glutmate weighted Magnetic Resonance Imaging (GluCEST) Deetects Effects of Transcranial Magentic Stimulation to the Motor Cortex. Neuroimage August 2022.

Jinyuan Zhou, Moritz Zaiss, Linda Knutsson, Phillip Zhe Sun, Sung Soo Ahn, Silvio Aime, Peter Bachert, Jaishri O. Blakeley, Kejia Cai, Michael A. Chappell, Min Chen, Daniel F. Gochberg, Steffen Goerke, Hye‐Young Heo, Shanshan Jiang, Tao Jin, Seong‐Gi Kim, John Laterra, Daniel Paech, Mark D. Pagel, Ji Eun Park, Ravinder Reddy, Akihiko Sakata, Sabine Sartoretti‐Schefer, A. Dean Sherry, Seth A. Smith, Greg J. Stanisz, Pia C. Sundgren, Osamu Togao, Moriel Vandsburger, Zhibo Wen, Yin Wu, Yi Zhang, Wenzhen Zhu, Zhongliang Zu, Peter C. M. van Zijl: Review and consensus recommendations on clinical APT‐weighted imaging approaches at 3T: Application to brain tumors. Magn Reson Med. 88((2)): 546, August 2022.

Nanga RPR, Elliott MA, Swain A, Wilson N, Swago S, Soni ND, Witschey WR, Reddy R. : Identification of L-Tryptophan by down field 1HMRS: A precursor for brain NAD+ and serotonin synthesis. Magn. Reson. Med. August 2022.

Abigail T.J. Cember, Neil E. Wilson, Laurie J. Rich, Puneet Bagga, Ravi Prakash Reddy Nanga, Sophia Swago, Anshuman Swain, Deepa Thakuri, Mark Elliot, Mitchell D. Schnall, John A. Detre, Ravinder Reddy: Integrating 1H MRS and deuterium labeled glucose for mapping the dynamics of neural metabolism in humans Neuroimage 251: 118977, June 2022.

Abigail T J. Cember, Ravi Prakash Reddy Nanga, Ravinder Reddy.: Glutamate-weighted CEST (GluCEST) imaging for mapping neurometabolism: An update on the state of the art and emerging findings from in vivo applications. NMR Biomed. May 2022.

Lone SN, Bhat AA, Wani NA, Karedath T, Hashem S, Nisar S, Singh M, Bagga P, Das BC, Bedognetti D, Reddy R, Frenneaux MP, El-Rifai W, Siddiqi MA, Haris M, Macha MA: miRNAs as novel immunoregulators in cancer. Semin Cell Dev Biol. 124: 3, April 2022.

Elizabeth Rosenfeld, Ravi Prakash Reddy Nanga, Alfredo Lucas, Andrew Y. Revell, Allison Thomas, Nina H. Thomas, David R. Roalf, Russel T. Shinohara, Ravinder Reddy, Kathryn A. Davis, Diva D. De León: Characterizing the neurological phenotype of the hyperinsulinism hyperammonemia syndrome. Orphanet J Rare Dis. 17: 315, 2022.

Gayatri Maria Schur, Julia Dunn, Sara Nguyen, Anna Dedio, Kristin Wade, Jaclyn Tamaroff, Nithya Mitta, Neil Wilson, Ravinder Reddy, David R. Lynch, Shana E. McCormack: In vivo assessment of OXPHOS capacity using 3T CrCEST MRI in Friedreich’s ataxia. J Neurol. 269((5)): 2527, 2022.

Sabah Nisar, Ajaz A. Bhat, Tariq Masoodi, Sheema Hashem, Sabah Akhtar, Tayyiba Akbar Ali, Sara Amjad, Sanjeev Chawla, Puneet Bagga, Michael P. Frenneaux, Ravinder Reddy, Khalid Fakhro, Mohammad Haris: Genetics of glutamate and its receptors in autism spectrum disorder. Mol Psychiatry 27((5)): 2380, 2022.

Driscoll N, Erickson B, Murphy BB, Richardson AG, Robbins G, Apollo NV, Mentzelopoulos G, Mathis T, Hantanasirisakul K, Bagga P, Gullbrand SE, Sergison M, Reddy R, Wolf JA, Chen HI, Lucas TH, Dillingham TR, Davis KA, Gogotsi Y, Medaglia JD, Vitale FM: Xene-infused bioelectronic interfaces for multiscale electrophysiology and stimulation. Sci Transl Med. 13((612)): eabf8629, Sep 2021.

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Last updated: 09/13/2022
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