Alexis A. Topjian
Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania and the Children's Hospital of Philadelphia
Attending Physician, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA
Member, Medical Staff, Hospital of the University of Pennsylvania, Philadelphia, PA
Faculty Member, Center for Resuscitation Science, Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA
Fellowship Director, Pediatric Neurocritical Care , Children's Hospital of Philadelphia, Philadelphia, PA
Director, Pediatric Neurocritical Care Program, Anesthesia and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA
Associate Chief, Faculty Affairs, Critical Care Medicine, Children's Hospital of Philadelphia
Department: Anesthesiology and Critical Care
Contact information
Children's Hospital of Philadelphia
Department of Anesthesia and Critical Care Medicine
3401 Civic Center Boulevard
Philadelphia, PA 19104
Department of Anesthesia and Critical Care Medicine
3401 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-3915
Fax: 215-590-4327
Fax: 215-590-4327
Email:
topjian@email.chop.edu
topjian@email.chop.edu
Education:
BA (Biology)
Harvard College, 1996.
MD (Medicine)
Columbia College of Physicians & Surgeons, 2001.
MSCE (Masters in Clinical Epidemiology and Biostatistics)
University of Pennsylvania School of Medicine, 2011.
BA (Biology)
Harvard College, 1996.
MD (Medicine)
Columbia College of Physicians & Surgeons, 2001.
MSCE (Masters in Clinical Epidemiology and Biostatistics)
University of Pennsylvania School of Medicine, 2011.
Post-Graduate Training
Resident in Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, 2001-2004.
Fellow in Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, 2004-2007.
Permanent linkResident in Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, 2001-2004.
Fellow in Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, 2004-2007.
Description of Itmat Expertise
Dr. Topjian's research is targeted at improving neurologic and survival outcome following pediatric cardiac arrest. She is investigating induced therapeutic hypothermia to attenuate brain injury in these patients and the role of EEG biomarkers, as well as neuroimaging, for prognostication of brain injury.Selected Publications
Bach AM, Kirschen MP, Fung FW, Abend NS, Ampah S, Mondal A, Huh JW, Chen SL, Yuan I, Graham K, Berman JI, Vossough A, Topjian A: Association of EEG Background With Diffusion-Weighted Magnetic Resonance Neuroimaging and Short-Term Outcomes After Pediatric Cardiac Arrest. Neurology 102(5): e209134, March 2024.Kirschen MP, Ouyang M, Patel B, Berman JI, Burnett R, Berg RA, Diaz-Arrastia R, Topjian A, Huang H, Vossough A: Association between ASL MRI-derived cerebral blood flow and outcomes after pediatric cardiac arrest. Resuscitation Epub ahead of print, February 2024.
Raymond T, Topjian AA, Lasa J, Nadkarni VM, Kirschen MP, Petersen T, Wakeham M, Esangbedo I, Rajapreyar P, Sangmo Je, Griffis H, Zhang X, Francoeur: Cerebral Oximetry During Pediatric In-hospital Cardiac Arrest: A Multicenter Study of Survival and Neurologic Outcome. Critical Care Medicine Online ahead of print, January 2024.
Abend NS, Fung FW, Parikh D, Walsh K, Fitzgerald MP, Massey S, Topjian AA: Late Onset Findings During Extended EEG Monitoring Are Rare in Critically Ill Children. Journal of Clinical Neurophysiology Accepted 2024.
Ushpol A, Je S, Niles D, Majmudar T, Kirschen M, Del Castillo J, Buysse C, Topjian A, Nadkarni V, Gangadharan S; PediRES-Q investigators: Association of blood pressure with neurologic outcome at hospital discharge after pediatric cardiac arrest resuscitation. Resuscitation December 2023.
Yuan I, Georgostathi G, Zhang B, Hodges A, Kurth CD, Kirschen MP, Huh JW, Topjian AA, Lang SS, Richter A, Abend NS, Massey SL: Quantitative electroencephalogram in term neonates under different sleep states. Journal of Clinical Monitoring and computing Online ahead of print, October 2023.
Gardner MM, Yan Wang Y, Himebauch AS, Conlon TW, Graham K, Morgan RW, Feng R, Berg RA, Yehya N, Mercer-Rosa L, Topjian AA: Impaired Echocardiographic Left Ventricular Global Longitudinal Strain after Pediatric Cardiac Arrest Children is Associated with Mortality. Resuscitation 191(109936), October 2023.
Gardner MM, Hehir DA, Reeder RW, Ahmed T, Bell MJ, Berg RA, Bishop R, Bochkoris M, Burns C, Carcillo JA, Carpenter TC, Dean JM, Diddle JW, Federman M, Fernandez R, Fink EL, Franzon D, Frazier AH, Friess SH, Graham K, Hall M, Harding ML, Horvat CM, Huard LL, Maa T, Manga A, McQuillen PS, Meert KL, Morgan RW, Mourani PM, Nadkarni VM, Naim MY, Notterman D, Pollack MM, Sapru A, Schneiter C, Sharron MP, Srivastava N, Tilford B, Viteri S, Wessel D, Wolfe HA, Yates AR, Zuppa AF, Sutton RM, Topjian AA: Identification of post-cardiac arrest blood pressure thresholds associated with outcomes in children: an ICU-Resuscitation study. Critical Care 27(1): 388, October 2023.
Jacobwitz M, Mulvihill CA, Helbig I, Topjian AA, Abend NS, Gonzalez AK, Kaufman MC, Resendiz KV, Francoeur C: A Comparison of Ketamine Versus Midazolam as First-Line Anesthetic Infusions for Pediatric Status Epilepticus. Neurocritical Care September 2023.
Hong S, Wainwright MS, Abend NS, Appavu BL, Francoeur C, Erkauer JC, Guerguerian A, Guerriero RM, Guilliams KP, Lee-Eng J, Loeb J, Lovett ME, Murphy SA, Pardo AC, Pineda JA, Ruzas CM, Topjian AA: A Survey of Pediatric Neurocritical Care Fellowship Training in North America. Pediatric Neurology 146: 1-7, September 2023.