Alexis A. Topjian

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Associate Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania and the Children's Hospital of Philadelphia
Member, Medical Staff, Hospital of the University of Pennsylvania, Philadelphia, PA
Department: Anesthesiology and Critical Care

Contact information
The Children's Hospital of Philadelphia
Department of Anesthesia and Critical Care Medicine
34th Street and Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-3915
Fax: 215-590-4327
B.A. (Biology)
Harvard College, 1996.
M.D. (Medicine)
Columbia College of Physicians & Surgeons, 2001.
M.S.C.E. (Masters in Clinical Epidemiology and Biostatistics)
University of Pennsylvania School of Medicine, 2011.
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Description of Itmat Expertise

Dr. Topjian's research is targeted at improving neurologic and survival outcome following pediatric cardiac arrest. She is investigating induced therapeutic hypothermia to attenuate brain injury in these patients and the role of EEG biomarkers, as well as neuroimaging, for prognostication of brain injury.

Selected Publications

Abend NS, Xiao R, Kessler SK, Topjian AA: Stability of early EEG background patterns after pediatric cardiac arrest. Journal of Clinical Neurophysiology 35(3): 246-250, May 2018.

Sanchez Ferenandez I, Gainza-Lein M, Abend NS, Anderson AE, Arya R, Brenton JN, Carpenter JL, Chapman KE, Clark J, Gaillard WD, Glauser TA, Goldstein JL, Goodkin HP, Helseth AR, Jackson MC, Kapur K, Lai YC, McDonough TL, Mikati MA, Nayak A, Peariso K, Riviello JJ, Tasker RC, Tchapyjnikov D, Topjian AA, Wainwright MS, Wilfong A, Williams K, Loddenkemper T; Pediatric Status Epilepticus Research Group (pSERG): Factors associated with treatment delays in pediatric refractory convulsive status epilepticus. Neurology 90(19): e1692-e1701, May 2018.

Abend NS, Wiebe DJ, Xiao R, Massey SL, Fitzgerald M, Fung F, Topjian AA: EEG factors after pediatric cardiac arrest. Journal of Clinical Neurophysiology 35(3): 251-255, May 2018.

Kirschen MP, Snyder M, Winters M, Ichord R, Berg RA, Nadkarni VM, Topjian AA: Survey of bedside clinical neurologic assessments in US PICUs. Pediatric Critical Care Medicine 19(4): 339-344, April 2018.

Gainza-Lein M, Fernandez IS, Jackson M, Abend NS, Arya R, Brento JN, Carpenter JL, Carpenter JL, Chapman KE, Gaillard WD, Glauser TA, Goldstein JL, Goodkin HP, Kapur K, Mikati MA, Peariso K, Tasker RC, Tchapjnikov D, Topjian AA, Wainwright MS, Wilfong A, Williams K, Loddenkemper T; for the Pediatric Status Epilepticus Research Group: Association of time to treatment with short-term outcomes for pediatric patients with refractory convulsive status epilepticus. JAMA Neurology 75(4): 410-418, April 2018.

Morgan RW, Stinson HR, Wolfe HA, Lindell RB, Topjian AA, Nadkarni VM, Sutton RM, Berg RA, Kilbaugh TJ: Pediatric in-hospital cardiac arrest secondary to acute pulmonary embolism. Critical Care Medicine 46(3): e229-e234, March 2018.

Holmberg MJ, Moskowitz A, Raymond TT, Berg RA, Nadkarni VM, Topjian AA, Grossestreuer AV, Donnino MW, Andersen LW, for the American Heart Association’s Get With The Guidelines®-Resuscitation Investigators: Derivation and internal validation of a mortality prediction tool for initial survivors of pediatric in-hospital cardiac arrest. Pediatric Critical Care Medicine 19(3): 186-195, March 2018.

Topjian AA, Telford R, Holubkov R, Nadkarni VM ,Berg RA, Dean JM, Moler FW; Therapeutic Hypothermia After Pediatric Cardiac Arrest (THAPCA) Trial Investigators: Association of early postresuscitation hypotension with survival to discharge after targeted temperature management for pediatric out-of-hospital cardiac arrest: Secondary analysis of a randomized clinical trial. JAMA Pediatrics 172(2): 143-153, February 2018.

Stinson HR, Srinivasan V, Topjian AA, Sutton RM, Nadkarni VM, Berg RA, Raymond TT; for the American Heart Association Get With the Guidelines-Resuscitation Investigators: Failure of invasive airway placement on the first attempt is associated with progression to cardiac arrest in pediatric acute respiratory compromise. Pediatric Critical Care Medicine 19(1): 9-16, January 2018.

Meert K, Guerguerian AM, Barbaro R, Slomine B, Christensen J, Berger J, Topjian AA, Bembea M, Tabbutt S, Fink, E, Schwartz S, Nadkarni VM, Telford R, Dean M, Moler F: Extracorporeal Cardiopulmonary Resuscitation: one-year survival and neurobehavioral outcome among infants and children with in-hospital cardiac arrest. Critical Care Medicine In Press 2018.

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Last updated: 11/16/2018
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