Alexis A. Topjian

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Associate Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania and the Children's Hospital of Philadelphia
Member, Medical Staff, Hospital of the University of Pennsylvania, Philadelphia, PA
Department: Anesthesiology and Critical Care

Contact information
The Children's Hospital of Philadelphia
Department of Anesthesia and Critical Care Medicine
34th Street and Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-3915
Fax: 215-590-4327
Education:
B.A. (Biology)
Harvard College, 1996.
M.D. (Medicine)
Columbia College of Physicians & Surgeons, 2001.
M.S.C.E. (Masters in Clinical Epidemiology and Biostatistics)
University of Pennsylvania School of Medicine, 2011.
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Description of Itmat Expertise

Dr. Topjian's research is targeted at improving neurologic and survival outcome following pediatric cardiac arrest. She is investigating induced therapeutic hypothermia to attenuate brain injury in these patients and the role of EEG biomarkers, as well as neuroimaging, for prognostication of brain injury.

Selected Publications

Stinson HR, Srinivasan V, Topjian AA, Sutton RM, Nadkarni VM, Berg RA, Raymond TT; for the American Heart Association Get With the Guidelines-Resuscitation Investigators: Failure of invasive airway placement on the first attempt is associated with progression to cardiac arrest in pediatric acute respiratory compromise. Pediatric Critical Care Medicine 19(1): 9-16, January 2018.

Morgan RW, Stinson HR, Wolfe HA, Lindell RB, Topjian AA, Nadkarni VM, Sutton RM, Berg RA, Kilbaugh TJ: Pediatric in-hospital cardiac arrest secondary to acute pulmonary embolism. Critical Care Medicine Epub ahead of print 2018.

Holmberg MJ, Moskowitz A, Raymond TT, Berg RA, Nadkarni VM, Topjian AA, Grossestreuer AV, Donnino MW, Andersen LW, for the American Heart Association’s Get With The Guidelines®-Resuscitation Investigators: Derivation and internal validation of a mortality prediction tool for initial survivors of pediatric in-hospital cardiac arrest. Pediatric Critical Care Medicine In Press 2018.

Topjian AA, Telford R, Holubkov R, Nadkarni VM ,Berg RA, Dean JM, Moler FW; Therapeutic Hypothermia After Pediatric Cardiac Arrest (THAPCA) Trial Investigators: Association of early postresuscitation hypotension with survival to discharge after targeted temperature management for pediatric out-of-hospital cardiac arrest: Secondary analysis of a randomized clinical trial. JAMA Pediatrics Epub ahead of print 2018.

Abend NS, Wiebe DJ, Xiao R, Massey SL, Fitzgerald M, Fung F, Topjian AA: EEG factors after pediatric cardiac arrest. Journal of Clinical Neurophysiology In Press 2018.

Abend NS, Xiao R, Kessler SK, Topjian AA: Stability of early EEG background patterns after pediatric cardiac arrest. Journal of Clinical Neurophysiology In Press 2018.

Abend NS, Massey SL, Fitzgerald M, Fung F, Atkin NJ, Xiao R, Topjian AA: Interrater agreement of EEG interpretation after pediatric cardiac arrest using standardized critical care EEG terminology. Journal of Clinical Neurophysiology 34(6): 534-541, November 2017.

Anderson LW, Vognsen M, Topjian AA, Brown L, Berg RA, Nadkarni VM: Pediatric in-hospital acute respiratory compromise: A report from the American Heart Association’s Get With The Guidelines-Resuscitation Registry. Pediatric Critical Care Medicine 18(9): 838-849, September 2017.

Idris AH, Bierens JJLM, Perkins GD, Wenzel V, Nadkarni V, Morley P, Warner DS, Topjian AA, Venema AM, Branche CM, Szpilman D, Morizo-Leite L, Nitta M, Lofgren B, Webber J, Grasner JT, Beerman SB, Youn CS, Jost U, Quan L, Dezfulian C, Handley AJ, Hazinski MF: 2015 revised Utstein-Style recommended guidelines for uniform reporting of data from drowning-related resuscitation: An ILCOR Advisory Statement. Resuscitation 118: 147-158, September 2017.

Zane NR, Reedy MD, Gastonguay MR, Himebauch AS, Ramsey EZ, Topjian AA, Zuppa AF: A population pharmacokinetic analysis to study the effect of therapeutic hypothermia on vancomycin disposition in children resuscitated from cardiac arrest. Pediatric Critical Care Medicine 18(7): e290-e297, July 2017.

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Last updated: 01/18/2018
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