Yejia Zhang

faculty photo
Assistant Professor of Physical Medicine and Rehabilitation at the Veteran's Administration Medical Center
Staff Physician, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA.
Department: Physical Medicine and Rehabilitation

Contact information
Penn Medicine at Rittenhouse
1800 Lombard Street/1st Floor
Philadelphia, PA 19146
Office: 215-893-2645
MD (Medicine)
Second Military Medical University, P.R. China, 1989.
PhD (Cell & Molecular Biology)
University of Pennsylvania, 1997.
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Description of Itmat Expertise

The ultimate goal of Dr. Zhang’s research is to develop non-operative treatments for intervertebral disc degeneration and related back pain.

In order to better understand the mechanism of intervertebral disc degeneration and discogenic back pain, tissues from cadaveric donors and patients undergoing spinal surgery were collected and molecular markers such as chemokines (e.g., IL-8) and matrix-degrading enzymes (e.g., ADAM-8) have been examined. Future studies include dissecting the upstream regulators and downstream effectors of these molecules in cultured disc cells and in genetically modified mice.

Selected Publications

Tian Zuozhen, Ma Xiaoyuan, Yasen Miersalijiang, Mauck Robert L, Qin Ling, Shofer Frances S, Smith Lachlan J, Pacifici Maurizio, Enomoto-Iwamoto Motomi, Zhang Yejia: Intervertebral Disc Degeneration in a Percutaneous Mouse Tail Injury Model. American journal of physical medicine & rehabilitation 97(3): 170-177, Mar 2018.

Chandra Abhishek, Wang Luqiang, Young Tiffany, Zhong Leilei, Tseng Wei-Ju, Levine Michael A, Cengel Keith, Liu X Sherry, Zhang Yejia, Pignolo Robert J, Qin Ling: Proteasome inhibitor bortezomib is a novel therapeutic agent for focal radiation-induced osteoporosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 32(1): 52-62, Jan 2018.

Liu Zunpeng, Yuan Xue, Liu Min, Fernandes Gabriela, Zhang Yejia, Yang Shuting, Ionita Ciprian N, Yang Shuying: Antimicrobial Peptide Combined with BMP2-Modified Mesenchymal Stem Cells Promotes Calvarial Repair in an Osteolytic Model. Molecular therapy : the journal of the American Society of Gene Therapy 26(1): 199-207, Jan 2018.

Chandra Abhishek, Lin Tiao, Young Tiffany, Tong Wei, Ma Xiaoyuan, Tseng Wei-Ju, Kramer Ina, Kneissel Michaela, Levine Michael A, Zhang Yejia, Cengel Keith, Liu X Sherry, Qin Ling: Suppression of Sclerostin Alleviates Radiation-Induced Bone Loss by Protecting Bone-Forming Cells and Their Progenitors Through Distinct Mechanisms. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 32(2): 360-372, Feb 2017.

Chee Ana, Shi Peng, Cha Thomas, Kao Ting-Hsien, Yang Shu-Hua, Zhu Jun, Chen Ding, Zhang Yejia, An Howard S: Cell Therapy with Human Dermal Fibroblasts Enhances Intervertebral Disk Repair and Decreases Inflammation in the Rabbit Model. Global spine journal 6(8): 771-779, Dec 2016.

Shi Peng, Chen Er-Yun, Cs-Szabo Gabriella, Chee Ana, Tannoury Chadi, Qin Ling, Lin Han, An Steven, An Howard S, Zhang Yejia: Biglycan Inhibits Capsaicin-Induced Substance P Release by Cultured Dorsal Root Ganglion Neurons. American journal of physical medicine & rehabilitation 95(9): 656-62, Sep 2016.

Zhang Yejia, Chee Ana, Shi Peng, Adams Sherrill L, Markova Dessislava Z, Anderson David Greg, Smith Harvey E, Deng Youping, Plastaras Christopher T, An Howard S: Intervertebral Disc Cells Produce Interleukins Found in Patients with Back Pain. American journal of physical medicine & rehabilitation 95(6): 407-15, Jun 2016.

Candela Maria Elena, Wang Chao, Gunawardena Aruni T, Zhang Kairui, Cantley Leslie, Yasuhara Rika, Usami Yu, Francois Noelle, Iwamoto Masahiro, van der Flier Arjan, Zhang Yejia, Qin Ling, Han Lin, Enomoto-Iwamoto Motomi: Alpha 5 Integrin Mediates Osteoarthritic Changes in Mouse Knee Joints. PloS one 11(6): e0156783, 2016.

Plastaras Christopher, Tsay Tiffany, Schran Seth, Zhang Yejia, Becker Scott, Pukenas Bryan: Vertebral Benign Notochordal Cell Tumor (BNCT) as an Incidental Finding in Cervical Radiculitis. PM & R : the journal of injury, function, and rehabilitation 7(11): 1198-200, Nov 2015.

Zhang Yejia, Chee Ana, Shi Peng, Wang Rui, Moss Isaac, Chen Er-Yun, He Tong-Chuan, An Howard S: Allogeneic Articular Chondrocyte Transplantation Downregulates Interleukin 8 Gene Expression in the Degenerating Rabbit Intervertebral Disk In Vivo. American journal of physical medicine & rehabilitation 94(7): 530-8, Jul 2015.

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Last updated: 10/01/2018
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