Allan I. Pack

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John Miclot Professor
Fellow, Institute on Aging, University of Pennsylvania, Philadelphia, PA
Member, Institute for Neurological Sciences, University of Pennsylvania, Philadelphia, PA
Director, Penn Sleep Center, University of Pennsylvania, Philadelphia, PA
Director, Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, PA
Member, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA
Member, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA
Assistant Dean and Director of Global Sleep Programs, Perelman School of Medicine, University of Pennsylvaia
Department: Medicine

Contact information
Center for Sleep and Circadian Neurobiology
Translational Research Laboratories
125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
Office: 215-746-4806
Fax: 215-746-4814
Graduate Group Affiliations
University of Glasgow, Scotland, 1967.
Ph.D. (Mathematical models of lung function)
University of Glasgow, Scotland, 1976.
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Description of Research Expertise

Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.

Description of Itmat Expertise

Major interest is in genomic/genetic approaches to sleep and its disorders. Studies to identify genetic risk factors for the common disorder sleep apnea and what determines the individual differences in response to sleep deprivation are in progress. These studies are being complemented by investigations to identify molecular signatures for sleep apnea and sleep deprivation. The approach being taken is to identify dynamic changes in expression of candidate genes and also expression profiling in circulating leukocytes and monocytes across the sleep period or with sleep deprivation.

Selected Publications

Pien, G.W., Ye, L., Keenan, B.T., Maislin, G., Bjornsdottir, E., Arnardottir, E.S., Benediktsdottir, B., Gislason, T. and Pack, A.I.: Changing faces of OSA: treatment effects by cluster designation in the Icelandic Sleep Apnea Cohort. Sleep Jan 2018 Notes: doi: 10.1093/sleep/zsx201. [Epub ahead of print]

Ly, S., Pack, A.I. and Naidoo, N.: The neurobiological basis of sleep: Insights from Drosophila. Neuroscience and Biobehavioral Reviews 87: 67-86, Jan 2018.

Keenan, B.T., Kim, J., Singh, B, Bittencourt, L., Chen, N.H., Cistulli, P.A., Magalang, U., McArdle, N., Mindel, J.W., Benediktsdottir, B., Arnardottir, E.S., Prochnow, L.K., Penzel, T., Sanner, B., Schwab, R., Shin, C., Sutherland, K., Tufik, S., Maislin, G., Gislason, T. and Pack, A.I.: Recognizable clinical subtypes of OSA across a worldwide sleep center population: a cluster analysis. Sleep 2018 Notes: 2018 Jan 5. doi: 10.1093/sleep/zsx214. [Epub ahead of print]

Younes, M., Kuna, S.T., Pack, A.I., Walsh, J.K., Kushida, C.A., Staley, B., and Pien, G.W.: Reliability of the American Academy of Sleep Medicine rules for assessing depth in clinical practice. Journal of Clinical Sleep Medicine 2018 Notes: Jan 16. pii: jc-17-00403. [Epub ahead of print]

Pak, V.M., Dai, F., Keenan, B.T., Gooneratne, N. and Pack, A.I.: Lower plasma choline levels are associated with sleepiness symptoms. Sleep Medicine 2017 (in press) Notes:

Jain, S., Gurubhagavatula, I, Townsend, R., Kuna, S.T., Teff, K, Wadden, T.a., Chittams, J., Hanlon, A.L., Maislin, G., Saif, H., Broderick, P., Ahmad, Z., Pack, A.I. and Chirinos, J.A.: Effect of CPAP, weight loss, or CPAP plus weight loss on central hemodynamics and arterial stiffness. Hypertension 70(6): 1283-1290, Dec 2017.

Thorarinsdottir, E.H., Arnardottir, E.S., Benediktsdottir, B., Janson, C., Olafsson, I., Pack, A.I., Gislason, T. and Keenan B.T.: Serum ferritin and obstructive sleep apnea-epidemiological study. Sleep & Breathing Dec 2017 Notes: doi: 10.1007/s11325-017-1598-y. [Epub ahead of print]

Chirinos, D.A., Gurubhagavatula, I., Broderick, P., Chirinos, J.A., Teff, K., Wadden, T., Maislin, G., Saif, H., Chittams, J., Cassidy, C., Hanlon, A.L. and Pack, A.I.: Depressive symptoms in patients with obstructive sleep apnea: biological mechanistic pathways. Journal of Behavioral Medicine 40(6): 955-963, Dec 2017.

Gao, X., Azarbarzin, A., Keenan, B.T., Ostrowski, M., Pack, F.M., Staley, B., Maislin, G., Pack, A.I., Younes, M. and Kuna, S.T.: Heritability of heart rate response to arousals in twins. Sleep 40(6), Jun 2017 Notes: doi: 10.1093/sleep/zsx055. [Epub ahead of print]

Morgan, A.P., Gatti, D.M., Najarian, M.L., Keane, T.M., Galante, R.J., Pack, A.I., Mott, R., Churchill, G.A., de Villena, F.P.: Structural variation shapes the landscape of recombination in mouse. Genetics 206(2): 603-619, Jun 2017.

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Last updated: 02/07/2018
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