Allan I. Pack

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John Miclot Professor
Fellow, Institute on Aging, University of Pennsylvania, Philadelphia, PA
Member, Institute for Neurological Sciences, University of Pennsylvania, Philadelphia, PA
Director, Penn Sleep Center, University of Pennsylvania, Philadelphia, PA
Director, Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, PA
Member, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA
Member, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA
Assistant Dean and Director of Global Sleep Programs, Perelman School of Medicine, University of Pennsylvaia
Department: Medicine

Contact information
Center for Sleep and Circadian Neurobiology
Translational Research Laboratories
125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
Office: 215-746-4806
Fax: 215-746-4814
Graduate Group Affiliations
University of Glasgow, Scotland, 1967.
Ph.D. (Mathematical models of lung function)
University of Glasgow, Scotland, 1976.
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Description of Research Expertise

Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.

Description of Itmat Expertise

Major interest is in genomic/genetic approaches to sleep and its disorders. Studies to identify genetic risk factors for the common disorder sleep apnea and what determines the individual differences in response to sleep deprivation are in progress. These studies are being complemented by investigations to identify molecular signatures for sleep apnea and sleep deprivation. The approach being taken is to identify dynamic changes in expression of candidate genes and also expression profiling in circulating leukocytes and monocytes across the sleep period or with sleep deprivation.

Selected Publications

Shulman, R., Cohen, D.L., Grandner, M.A., Gislason, T., Pack, A.I., Kuna, S.T., Townsend, D.R. and Cohen, J.B.: Sleep duration and 24-hour ambulatory blood pressure in adults not on antihypertensive medications. Journal of Clinical Hypertension Oct 2018 Notes: doi: 10.1111/jch.13416. [Epub ahead of print]

Feng, Y., Maislin, D., Keenan, B.T., Gislason, T., Arnardottir, E.S., Benediktsdottir, B., Chirinos, J.A., Townsend, R.R., Staley, B., Pack, F.M., Sifferman, A., Pack, A.I. and Kuna, S.T.: Physical activity following positive airway pressure treatment in adults with and without obesity and with moderate-severe obstructive sleep apnea. Journal of Clinical Sleep Medicine 14(10): 1705-1715, Oct 2018.

Varendh, M., Andersson, M., Bjornsdottir, E., Arnardottir, E.S., Gislason, T., Pack, A.I, Hrubos-Strom, H., Johannisson A. and Juliusson, S. : PAP treatment in patients with OSA does not induce long-term nasal obstruction. Journal of Sleep Research Sep 2018 Notes: Sep 28:e12768. doi: 10.1111/jsr.12768. [Epub ahead of print]

Naidoo, N., Zhu, J., Galante, R.J., Lian, J., Strus, E., Lee, A., Keenan, B.T., and Pack, A.I.: Reduction of the molecular chaperone binding immunoglobulin protein (BiP) accentuates the effect of aging on sleep-wake behavior. Neurobiology of Aging 69: 10-25, Sep 2018.

Magalang, U.J., Johns, J.N., Wood, K.A., Mindel, J.W., Lim, D.C., Bittencourt, L.R., Chen, N.H., Cistulli, P.A., Gislason, T., Arnardottir, E.S., Penzel, T., Tufik, S. and Pack, A.I.: Home sleep apnea testing: comparison of manual and automated scoring across international sleep centers. Sleep and Breathing Sep 2018 Notes: 2018 Sep 10. doi: 10.1007/s11325-018-1715-6. [Epub ahead of print]

van Hees, V.T., Sabia, S., Jones, S.E., Wood, A.R., Anderson, K.N., Kivimaki, M., Frayling, T.M., Pack, A.I., Bucan, M., Trenell, M.I., Mazzotti, D.R., Gehrman, P.R., Singh-Manoux, B.A. and Weedon, M.N.: Estimating sleep parameters using an accelerometer without sleep diary. Scientific Reports 8(1): 12975, Aug 2018.

Feng, Y., Keenan, B.T., Wang, S., Leinwand, S., Wiemken, A., Pack, A.I. and Schwab R.J.: Dynamic upper airway imaging during wakefulness in obese subjects with and without sleep apnea. American Journal of Respiratory and Critical Care Medicine Jul 2018 Notes: doi: 10.1164/rccm.201711-2171OC. [Epub ahead of print]

Mazzotti, D.R., Lim, D.C., Sutherland, K., Bittencourt, L., Mindel, J.W., Magalang, U., Pack, A.I., de Chazal, P. and Penzel, T.: Opportunities for utilizing polysomnography signals to characterize obstructive sleep apnea subtypes and severity. Physiological Measurement 39(9): 09TR01, Jul 26 2018 Notes: doi: 10.1088/1361-6579/aad5fe.

Pak, V.M., Mazzotti, D.R., Keenan, B.T., Hirotsu, C., Gehrman, P., Bittencourt, L., Pack, A.I. and Tufik, S.: Candidate gene analysis in the Sao Paulo Epidemiological Sleep Study (EPISONO) shows an association of variant in PDE4D and sleepiness. Sleep Medicine 47: 106-112, Jul 2018.

Perron, I.J., Keenan, B.T., Chellappa, K., Lahens, N.F., Yohn, N.L., Shockley, K.R., Pack, A.I. and Veasey, S.C.: Dietary challenges differentially affect activity and sleep/wake behavior in mus musculus: isolating independent associations with diet/energy balance and body weight. PLoS One 13(5): e0196743, May 10 2018.

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Last updated: 12/06/2018
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