Drew Weissman

faculty photo
Professor of Medicine
Co-Director, Penn Center for AIDS Research, Immunology Core
Director of Vaccine Research, Infectious Diseases Division
Department: Medicine

Contact information
410B Hill Pavilion
380 S University Ave.
Philadelphia, PA 19104
Office: (215) 573-8491
Graduate Group Affiliations
Education:
B.A., M.A. (Biochemistry/Enzymology)
Brandeis University, 1981.
M.D. Ph.D. (Immunology/Microbiology)
Boston University, 1987.
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Description of Research Expertise

Dr. Weissman's laboratory focuses on the study of RNA and innate immune system biology and the application of these findings to vaccine research and gene therapy. There are three main projects in his laboratory. The first project began through the use of mRNA encoding antigen as a delivery system to load dendritic cells to promote broad immune responses as part of a vaccine. This project has expanded to include basic studies of RNA immunogenicity and translation and the development of applications for gene therapy. The second project develops new HIV envelope immunogens that can induce broad responses and cross-reactive neutralizing antibodies. The third project continues previous studies that identified a protein found on DC, macrophages, and epithelial cells that binds HIV envelope with high affinity. The main focus of this project is testing whether this and related molecules function in vivo to promote HIV genital tract infection.

Description of Itmat Expertise

HIV vaccines, RNA immunity, mRNA gene therapy, mRNA vaccines

Selected Publications

Lo, M. K., Spengler, J. R., Welch, S. R., Harmon, J. R., Coleman-McCray, J. D., Scholte, F. E. M., Shrivastava-Ranjan, P., Montgomery, J. M., Nichol, S. T., Weissman, D., Spiropoulou, C. F.: Evaluation of a Single-Dose Nucleoside-Modified Messenger RNA Vaccine Encoding Hendra Virus-Soluble Glycoprotein Against Lethal Nipah virus Challenge in Syrian Hamsters. J Infect Dis. 221(Supplement_4): S493-S498. doi: 10.1093/infdis/jiz553. 2020.

Freyn, A. W., Ramos da Silva, J., Rosado, V. C., Bliss, C. M., Pine, M., Mui, B. L., Tam, Y. K., Madden, T. D., de Souza Ferreira, L. C., Weissman, D., Krammer, F., Coughlan, L., Palese, P., Pardi, N., Nachbagauer, R.: A Multi-Targeting, Nucleoside-Modified mRNA Influenza Virus Vaccine Provides Broad Protection in Mice. Mol Ther 19(20): 30199-4, 2020.

Cable, J., Srikantiah, P., Crowe, J. E., Jr., Pulendran, B., Hill, A., Ginsberg, A., Koff, W., Mathew, A., Ng, T., Jansen, K., Glenn, G., Permar, S., Wilson, I., Weiner, D. B., Weissman, D., Rappuoli, R.: Vaccine innovations for emerging infectious diseases-a symposium report. Ann N Y Acad Sci. 1462(1): 14-26. doi: 10.1111/nyas.14235. Epub 2019 Oct 28. 2020.

Alameh, M. G., Weissman, D., Pardi, N.: Messenger RNA-Based Vaccines Against Infectious Diseases. Curr Top Microbiol Immunol 17(10), 2020.

Willis, E., Pardi, N., Parkhouse, K., Mui, B. L., Tam, Y. K., Weissman, D., Hensley, S. E.: Nucleoside-modified mRNA vaccination partially overcomes maternal antibody inhibition of de novo immune responses in mice. Sci Transl Med. 12(525): eaav5701. doi: 10.1126/scitranslmed.aav5701. 2020.

Ravimohan, S., Auld, S. C., Maenetje, P., Ratsela, N., Mlotshwa, M., Ncube, I., Smith, J. P., Vangu, M. D., Sebe, M., Kossenkov, A., Weissman, D., Wallis, R. S., Churchyard, G., Kornfeld, H., Bisson, G. P.: Lung Injury on Antiretroviral Therapy in Adults With Human Immunodeficiency Virus/Tuberculosis. Clin Infect Dis. 70(9): 1845-1854. doi: 10.1093/cid/ciz560. 2020.

Raj, D. K., Das Mohapatra, A., Jnawali, A., Zuromski, J., Jha, A., Cham-Kpu, G., Sherman, B., Rudlaff, R. M., Nixon, C. E., Hilton, N., Oleinikov, A. V., Chesnokov, O., Merritt, J., Pond-Tor, S., Burns, L., Jolly, G., Ben Mamoun, C., Kabyemela, E., Muehlenbachs, A., Lambert, L., Orr-Gonzalez, S., Gn├Ądig, N. F., Fidock, D. A., Park, S., Dvorin, J. D., Pardi, N., Weissman, D., Mui, B. L., Tam, Y. K., Friedman, J. F., Fried, M., Duffy, P. E., Kurtis, J. D.: Anti-PfGARP activates programmed cell death of parasites and reduces severe malaria. Nature 22(10): 020-2220, 2020.

Pardi, N., Hogan, M. J., Weissman, D.: Recent advances in mRNA vaccine technology. Curr Opin Immunol. 65:14-20.(doi): 10.1016/j.coi.2020.01.008. 2020.

Lo Michael K, Spengler Jessica R, Welch Stephen R, Harmon Jessica R, Coleman-Mccray Joann D, Scholte Florine E M, Shrivastava-Ranjan Punya, Montgomery Joel M, Nichol Stuart T, Weissman Drew, Spiropoulou Christina F: Evaluation of a Single-Dose Nucleoside-Modified Messenger RNA Vaccine Encoding Hendra Virus-Soluble Glycoprotein Against Lethal Nipah virus Challenge in Syrian Hamsters. The Journal of infectious diseases Nov 2019.

Ravimohan Shruthi, Maenetje Pholo, Auld Sara C, Ncube Itai, Mlotshwa Mandla, Chase William, Tiemessen Caroline T, Vangu Mboyo-Di-Tamba, Wallis Robert S, Churchyard Gavin, Weissman Drew, Kornfeld Hardy, Bisson Gregory P: A Common NLRC4 Gene Variant Associates With Inflammation and Pulmonary Function in Human Immunodeficiency Virus and Tuberculosis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Nov 2019.

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Last updated: 05/26/2020
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