Julia C. Tchou

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Associate Professor of Clinical Surgery
Attending surgeon, Hospital of the University of Pennsylvania, Philadelphia, PA
Course Director, Breast Surgery Elective, University of Pennsylvania School of Medicine, Philadelphia, PA
Breast Cancer Research Program Steering Committee, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
Breast Surgery Section Chief, Hospital of the University of Pennsylvania, Philadelphia, PA
Co-Director, Rena Rowan Breast Center, Abramson Cancer Center, Philadelphia, PA
Department: Surgery

Contact information
Division of Endocrine & Oncologic Surgery
3400 Civic Center Boulevard
Perelman Center, 3rd Floor West
Philadelphia, PA 19104-4283
Office: 215-615-7575
College of Mount Saint Vincent, Riverdale, NY, 1987.
State University of New York at Stony Brook School of Medicine, Stony Brook, NY, 1993.
State University of New York at Stony Brook School of Medicine, Stony Brook, NY, 1995.
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Description of Research Expertise

My research is focused on 1) developing strategies to mitigate breast cancer risk associated with metabolic syndrome by lifestyle modifications and by re-purposing some of the commonly prescribed medications to prevent breast cancer initiation and progression; 2) elucidating how novel immunotherapy such as CAR T therapy can induce epitope spreading and how combination therapy can unleash the anti-tumor effects of our own immune system; and 3) how we can use large data to enhance our understanding of tumor biology with the common goal of improving breast cancer outcomes.

Selected Publications

Modarressi T, Levine MA, Tchou J, Khan AN: Gestational gigantomastia complicated by PTHrP-mediated hypercalcemia. Journal of Clinical Endocrinology & Metabolism July 18 2018 (Epub).

Williams AD, Li YR, So A, Steel L, Carrigan E, Ro V, Nguyen J, Tchou J: The impact of aspirin use on breast cancer subtype and clinical course. Journal of Surgical Research 230: 71-79, Oct. 2018 Notes: (Epub May 25, 2018).

Williams AD, Reyes SA, Arlow RL, Tchou J, De La Cruz LM: Is age trumping genetic profiling in clinical practice? Relationship of chemotherapy recommendation and oncotype DX recurrence score in patients aged < 50 years versus ≥ 50 years, and trends over time. Annals of Surgical Oncology 25(10): 2875-2883, Oct. 2018 Notes: (Epub June 29, 2018).

Williams AD, So A, Tchou J: Overall survival is similar between women who seek care at one or more institutions after diagnosis of operable breast cancer in the community. Surgical Oncology 27(3): 387-391, Sept. 2018 Notes: (Epub May 26, 2018).

Yoon-Flannery K, DeStefano LM, De La Cruz LM, Fisher CS, Lin LY, Coffua LS, Mustafa RE, Sataloff DM, Tchou JC, Brooks AD: Quality of life and sexual well-being after nipple sparing mastectomy: A matched comparison of patients using the breast Q. Journal of Surgical Oncology 118(1): 238-242, July 2018 Notes: (Epub Aug. 16, 2018).

So Alycia, De La Cruz Lucy M, Williams Austin D, Bahng Joseph, Liao Geraldine, McDonald Elizabeth S, Fisher Carla S, Czerniecki Brian J, Sataloff Dahlia, Tchou Julia: The impact of preoperative magnetic resonance imaging and lumpectomy cavity shavings on re-excision rate in pure ductal carcinoma in situ-A single institution's experience. Journal of Surgical Oncology 117(4): 558-566, Mar. 2018 Notes: (Epub Nov. 11, 2017).

Tchou Julia, Zhao Yangbing, Levine Bruce L, Zhang Paul J, Davis Megan M, Melenhorst Jan Joseph, Kulikovskaya Irina, Brennan Andrea L, Liu Xiaojun, Lacey Simon F, Posey Avery D, Williams Austin D, So Alycia, Conejo-Garcia Jose R, Plesa Gabriela, Young Regina M, McGettigan Shannon, Campbell Jean, Pierce Robert H, Matro Jennifer M, DeMichele Angela M, Clark Amy S, Cooper Laurence J, Schuchter Lynn M, Vonderheide Robert H, June Carl H: Safety and efficacy of intratumoral injections of chimeric antigen receptor (CAR) T cells in metastatic breast cancer. Cancer Immunology Research 5(12): 1152-1161, Dec. 2017 Notes: (Epub Nov. 6, 2017).

Williams AD, Payne KK, Posey AD Jr, Hill C, Conejo-Garcia J, June CH, Tchou J: Immunotherapy for breast cancer: Current and future strategies. Current Surgical Reports 5: pii: 31, Dec. 2017 Notes: (Epub Oct. 10, 2017).

Mustafa Rose E, DeStefano Lauren M, Bahng Joey, Yoon-Flannery Kahyun, Fisher Carla S, Zhang Paul J, Tchou Julia, Czerniecki Brian J, De La Cruz Lucy M: Evaluating the risk of upstaging HER2-positive DCIS to invasive breast cancer. Annals of Surgical Oncology 24(10): 2999-3003, Oct. 2017 Notes: (Epub Aug. 1, 2017).

Williams Austin D, So Alycia, Synnestvedt Marie, Tewksbury Colleen M, Kontos Despina, Hsiehm Meng-Kang, Pantalone Lauren, Conant Emily F, Schnall Mitchell, Dumon Kristoffel, Williams Noel, Tchou Julia: Mammographic breast density decreases after bariatric surgery. Breast Cancer Research & Treatment 165(3): 565-572, Oct. 2017 Notes: (Epub June 28, 2017).

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Last updated: 10/24/2018
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