Xiaowei Xu

faculty photo
Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Attending Physician, Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia PA
Member, Abramson Cancer Center
Department: Pathology and Laboratory Medicine

Contact information
Hospital of University of Pennsylvania
Dept. of Pathology and Laboratory Medicine
6 Founders Pavilion
Philadelphia, PA 19104-4283
Office: 215-662-6503
Fax: 215-349-5910
MD (Medicine)
Fudan University School of Medicine, Shanghai, China, 1992.
PhD (Pharmacology)
Wake Forest University School of Medicine, Winston-Salem, NC, 1996.
Post-Graduate Training
Postdoctoral Fellowship, Department of Physiology and Pharmacology, Dr. William Sonntag's Lab, Wake Forest University, Winston Salem, NC, 1996-1997.
Resident in Anatomic and Clinical Pathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, 1997-2001.
Postdoctoral Fellowship, Department of Dermatology, Dr. George Cotsarelis' Lab, University of Pennsylvania, Philadelphia, PA, 1999-2001.
Clinical Fellowship in Dermatopathology, Harvard Medical School, Boston, MA, 2001-2002.
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Description of Research Expertise

Skin stem cells and melanoma

Description of Itmat Expertise

Dr. Xu's lab studies skin adult stem cell, melanocyte and melanoma biology with aims to effective therapies for vitiligo, melasma, melanoma and other skin conditions.

Selected Publications

Yang R, Jiang M, Kumar SM, Xu T, Wang F, Xiang L, Xu X: Generation of melanocytes from Induced pluripotent stem cells J Invest Dermatol 131(12): 2458-66, 2011

Yang R, Xu X: Isolation of neural crest stem cells from human hair follicles. J Vis Exp 74: 3194, Apr 2013 Notes: Epub: doi: 10.3791/3194 with video: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644479/bin/jove-74-3194.mov.

Guo J, Si L, Kong Y, Flaherty KT, Xu X, Zhu Y, Corless CL, Li L, Li H, et al : A Phase II, Open Label, Single-arm Trial of Imatinib Mesylate in Patients with Metastatic Melanoma Harboring c-Kit Mutation or Amplification. J Clin Onco 29(21): 2904-9, 2011.

Yun SJ, Gimotty PA, Hwang WT, Dawson P, Van Belle P, Elder DE, Elenitsas R, Schuchter L, Guerry D, Xu X : High Lymphatic Vessel Density and Lymphatic Invasion Underlie the Adverse Prognostic Effect of Radial Growth Phase Regression in Melanoma Am J Surg Path 35(3): 235-42, 2011.

Yu H, Kumar SM, Kossenkov AV, Showe L, Xu X: Stem Cells with Neural Crest Characteristics Derived from the Bulge Region of Cultured Human Hair Follicles J Invest Dermatol 130(5): 1227-36, 2010.

Bollag G, Hirth P, Tsai J, Zhang J, Ibrahim PN, Cho H, Spevak W, Zhang C, Zhang Y, Habets G, Burton B, West BL, Powell B, Shellooe R, Marimuthu A, Nguyen H, Zhang KYJ, Artis DR, Schlessinger J, Su F, Higgins B, Iyer R, D’Andrea K, Koehler A, Stumm M, Lee RJ, Grippo J, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, Chapman PB, Flaherty KT, Xu X, Nathanson KL, Nolop K: Clinical efficacy of a RAF inhibitor requires comprehensive ERK pathway inhibition in BRAF-mutant melanoma. Nature 467(7315): 596-9, 2010

Villanueva J, Vultur A, Lee JT, Somasundaram R, Fukunaga-Kalabis1 M, Cipolla1 AK, Wubenhorst B, Xu X, Gimotty PA, Kee D, Santiago-Walker1 AE, Letrero R, Pushparajan A, Hayden JE, Laquerre S, McArthur GA, Sosman JA, Nathanson KL, Herlyn M: Acquired resistance to BRAF inhibitors mediated by an A/B/C RAF kinase switch in melanoma can be overcome by co-targeting MEK and IGF-1R/PI3K. Cancer Cell 18(6): 683-95, 2010.

Li, L., Fulunaga-Kalabis, M., Yu, H., Xu, X., Kong, J., Lee, J.T. Herlyn, M.: : Melanocyte stem cells can be isolated from the human dermis. J Cell Sci 123(6): 853-60, 2010.

Zhang G, Zhang H, Wang Q, Lal P, Carroll A, de la Llera-Moya M, Xu X, Greene MI. : Suppression of human prostate tumor growth by a prostate-specific monoclonal antibody F77 targeting a unique cell surface marker. Proc Natl Acad Sci U S A 107(2): 732-7, 2010.

Yu H., Fang D., Kumar SM., Li L., Nguyen TK., Acs G., Herlyn M., Xu X.: Isolation of a novel population of multipotent adult stem cells from human hair follicles. American Journal of Pathology 168(6): 1879-88, 2006.

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Last updated: 06/24/2022
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