Gregory P Bisson

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Assistant Professor of Medicine
Attending Physician, Philadelphia Veterans Affairs Medical Center
Senior Scholar, Department of Biostatistics and Epidemiology, Perelman School of Medicine
Department: Medicine

Contact information
832 Blockley Hall
423 Guardian Drive
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania
Philadelphia, PA 19104-6021
Office: 215-573-5811
Fax: 215-573-5315
BA (Japanese)
University of Wisconsin-Madison, 1992.
University of Minnesota School of Medicine, 1997.
MSCE (Epidemiology)
Perelman School of Medicine, University of Pennsylvania, 2006.
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Description of Research Expertise

My research is dedicated to improving treatment outcomes of patients with HIV and tuberculosis (TB) and other AIDS-associated opportunistic infections. Current research projects are evaluating the relationship between very early virologic and immunologic response to antiretroviral therapy and clinical outcomes in adults with HIV/TB. Many patients with advanced HIV die soon after antiretroviral therapy initiation, and our research group focuses on trying to understand the pathophysiologic and social mechanisms underlying these early deaths. In addition, we are pursuing translational projects evaluating novel host-directed therapies for treatment of drug resistant TB.

Description of Itmat Expertise

HIV infection, tuberculosis, cryptococcal meningitis, host-directed therapy, HIV treatment monitoring in resource-limited settings, drug resistance

Selected Publications

Hosseinipour MC*, Bisson GP*, Miyahara S, Sun X, Moses A, Riviere C, Kirui FK, Badal-Faesen S, Lagat D, Nyirenda M, Naidoo K, Hakim J, Mugyenyi P, Henostroza G, Leger PD, Lama JR, Mohapi L, Alave J, Mave V, Veloso VG, Pillay S, Kumarasamy N, Bao J, Hogg E, Jones L, Zolopa A, Kumwenda J, Gupta A and the Adult AIDS Clinical Trials Group A5274 (REMEMBER) Study Team: Empiric Tuberculosis Therapy versus Isoniazid in Advanced HIV-infected Adult Outpatients Initiating Antiretroviral Therapy: a Multi-Country Randomized Controlled Trial. The Lancet 387 (10024): 1198-209, March 2016 Notes: *Contributed equally.

Gross R, Bellamy S, Ratshaa B, Han X, Steenhoff A, Mosepele M, Bisson GP: Effects of Alcohol Use and Sex on Antiretroviral Therapy Outcomes in Botswana: A Cohort Study. Addiction July 2016 Notes: Epub ahead of print.

Zentner I, Schlecht H, Khensouvann L Tamuhla N, Kutzler M, Ivaturi V, Pasipanodya J, Gumbo T, Peloquin C, Bisson GP, Vinnard C : Urine Colorimetry to Detect Low Rifampin Exposure during Tuberculosis Therapy: A Proof-of-Concept Study BMC Infectious Diseases 16(1): 242, June 2016.

Okatch H, Bellamy S, Han X, Ratshaa B, Steenhoff A, Mosepele M, Bisson GP, Gross R: CD4 cell counts at antiretroviral therapy initiation in Botswana have been increasing. Clinical Infectious Diseases 62(5): 669-70, March 2016 Notes: Comment.

Ravimohan S, Tamuhla N, Nfanyana K, Steenhoff AP, Letlhogile R, Frank I, MacGregor RR, Gross R, Weissman D, Bisson GP: Robust Reconstitution of Tuberculosis-Specific Polyfunctional CD4+ T-Cell Responses and Rising Systemic Interleukin 6 in Paradoxical Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome. Clinical Infectious Diseases 62(6): 795-803, March 2016.

Bisson GP, Gupta A, Miyahara S, Sun X, Bao J, Fry C, Manabe Y, Kumwenda J, Hosseinipour MC, on behalf of the Adult AIDS Clinical Trials Group A5274 (REMEMBER) Study Team: Urine LAM testing in advanced HIV-infected adults in a trial of empiric TB therapy. 23rd Conference on Retroviruses and Opportunistic Infections (CROI) Boston, MA February 2016 Notes: Poster Presentation.

Kumwenda J, Gupta A, Sun X, Miyahara S, Bao J, Hogg E, Jones L, Zolopa A, Bisson GP, Hosseinipour MC on behalf of the Adult AIDS Clinical Trials Group A5274 (REMEMBER) Study Team: Empiric TB therapy versus IPT in HIV-infected persons initiating ART (ACTG A5274 48 week results) 23rd Conference on Retroviruses and Opportunistic Infections (CROI) Boston, MA February 2016 Notes: Poster Presentation.

Ravimohan S, Tamuhla N, Kung SJ, Nfanyana K, Steenhoff AP, Gross R, Weissman D, Bisson GP: Matrix metalloproteinases in TB-IRIS and impaired lung function among advanced HIV/TB co-infected patients initiating ART. eBiomedicine. Elsevier, 3: 100-107, January 2016.

Han JH, Gordon K, Womack JA, Gibert CL, Leaf DA, Rimland D, Rodriquez-Barradas MC, Bisson GP : Comparative Effectiveness of Diabetic Oral Medications among HIV-Infected and HIV-Uninfected Veterans. Diabetes Care In press 2016.

Ravimohan S, Bisson GP: To have and have not: dissecting protective and pathologic immune recovery in TB-IRIS Future Virology 10(11): 1217-1229, November 2015.

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Last updated: 08/29/2016
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