William H. Peranteau

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Assistant Professor of Surgery
Active Surgeon, Children's Hospital of Philadelphia, Philadelphia, PA
Active Surgeon, Pennsylvania Hospital, Philadelphia, PA
Attending Surgeon, Hospital of the University of Pennsylvania, Philadelphia, PA
Department: Surgery

Contact information
Division of Pediatric General, Thoracic and Fetal Surgery
The Children's Hospital of Philadelphia
34th Street & Civic Center Boulevard
5th Floor, Wood Center
Philadelphia, PA 19104
Office: 215-590-2730
Fax: 215-590-4875
BA (molecular biology)
Princeton University, Princeton, NJ, 1997.
University of Pennsylvania School of Medicine, Philadelphia, PA, 2002.
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Description of Itmat Expertise

My interest primarily involves the study of in utero hematopoietic cell transplantation and in utero gene therapy/editing as potential therapeutic avenues for many congenital hematologic and genetic disorders such as Sickle cell disease, Tyrosinemia, and Friedreich's ataxia. We are currently investigating mechanisms to optimize the success and safety of these techniques in the murine and preclinical canine model prior to translation into clinical utility.

Description of Research Expertise

I have an interest in fetal development as it relates to the potential understanding of and fetal intervention for congenital anomalies. Specifically, I have had a deep interest and significant experience evaluating in utero hematopoietic stem cell transplantation in the murine and canine model. These studies provide interesting information and address basic questions on the development of the fetal hematopoietic niche. One of the main goals of my research is a better understanding of the barriers to successful allogeneic in utero bone marrow transplantation. Allogeneic in utero bone marrow transplantation would allow for nonmyeloablative unmatched transplants without the need for immunosuppression and thus holds significant clinical promise for the treatment of hemoglobinopathies, such as Sickle Cell disease.

Selected Publications

Peranteau WH, Mattei P: Hernias. Comprehensive Pediatric Hospital Medicine, 2d Edition. Zaoutis LB, Chiang VW (eds.). New York: McGraw Hill Medical, 2017 (in press).

Peranteau WH: Sacrococcygeal teratomas. Fundamentals of Pediatric Surgery, 2d Edition. Mattei P (eds.). New York: Springer, 2017 (in press).

Laje P, Blinman TA, Nance ML, Peranteau WH: Laparoscopic fundoplication in neonates and young infants: Failure rate and need for redo at a high-volume center. Journal of Pediatric Surgery 52(2): 257-259, Feb 2017.

Peranteau WH, Iyoob SD, Boelig MM, Khalek N, Moldenhauer JS, Johnson MP, Hedrick HL, Flake AW, Coleman BG, Adzick NS: Prenatal growth characteristics of lymphatic malformations. Journal of Pediatric Surgery 52(1): 65-68, Jan 2017.

Gebb JS, Khalek N, Qamar H, Ozcan T, Johnson MP, Rendon N, Oliver ER, Coleman BG, Peranteau WH, Hedrick HL, Flake AW, Adzick NS, Moldenhauer JS: Tumor volume to fetal weight ratio > 0.12 is associated with worse perinatal outcomes in fetuses with sacrococcygeal teratoma. American Journal of Obstetrics & Gynecology 216(1 Suppl): S118, 2017.

Kim AG, Vrecenak JD, Boelig MM, Eissenberg L, Rettig MP, Riley JS, Holt MS, Conner MA, Loukogeorgakis SP, Li H, DiPersio JF, Flake AW, Peranteau WH: Enhanced in utero allogeneic engraftment in mice after mobilizing fetal HSCs by α4β1/7 inhibition. Blood 128(20): 2457-2461, Nov 2016.

Burgos CM, Pearson EG, Davey M, Riley J, Jia H, Laje P, Flake AW, Peranteau WH: Improved pulmonary function in the nitrofen model of congenital diaphragmatic hernia following prenatal maternal dexamethasone and/or sildenafil. Pediatric Research 80(4): 577-585, Oct 2016.

Antiel RM, Riley JS, Cahill PJ, Campbell RM, Waqar L, Herkert LM, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL: Management and outcomes of scoliosis in children with congenital diaphragmatic hernia. Journal of Pediatric Surgery Sept. 2016.

Danzer E, Gerdes M, D'Agostino J, Bernbaum J, Hoffman C, Herkert LM, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL: Younger gestational age is associated with increased risk of adverse neurodevelopmental outcome during infancy in congenital diaphragmatic hernia. Journal of Pediatric Surgery 51(7): 1084-1090, July 2016.

Partridge EA, Peranteau WH, Herkert L, Rendon N, Smith H, Rintoul NE, Flake AW, Adzick NS, Hedrick HL: Right- versus left-sided congenital diaphragmatic hernia: A comparative outcomes analysis. Journal of Pediatric Surgery 51(6): 900-902, June 2016.

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Last updated: 02/10/2017
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