Jeffrey S Barrett

faculty photo
Adjunct Professor of Pediatrics
Department: Pediatrics

Contact information
The Children's Hospital of Philadelphia
Colket Translational Research Building, Room 4012
3501 Civic Center Boulevard
Philadelphia, PA 19104-4318
Office: (267) 426-5479
Fax: (267) 425-0114
Graduate Group Affiliations
BS (Chemical Engineering)
Drexel University, 1986.
MS (Pharmacokinetics)
University of Michigan, 1987.
PhD (Pharmacokinetics)
University of Michigan, 1990.
Permanent link

Description of Itmat Expertise

Dr. Barrett investigates sources of variation in pharmacokinetics and pharmacodynamics, and the development of pharmacometric approaches to advance PK/PD, novel biomarker development and disease progression modeling.

Selected Publications

Barrett JS, Spitsin S , Moorthy G, Barrett KJ, Baker K, Lackner A, Tulic F, Winters A, Evans DL and Douglas SD. : Pharmacologic rationale for the NK1R antagonist, aprepitant as adjunctive therapy in HIV. J Transl Med. 14(1): 148, 2016.

Tebas P, Spitsin S, Barrett JS, Tuluc F, Elci O, Korelitz JJ, Wagner W, Winters A, Kim D, Catalano R, Evans DL, Douglas SD. : Reduction of soluble CD163, substance P, programmed death 1 and inflammatory markers: phase 1B trial of aprepitant in HIV-1-infected adults. AIDS 29(8): 931-9, 2015.

Stockmann C, Barrett JS, Roberts JK, Sherwin CMT. : Use of Modeling and Simulation in the Design and Conduct of Pediatric Clinical Trials and the Optimization of Individualized Dosing Regimens. CPT Pharmacometrics Syst Pharmacol 4(11): 630-40, 2015.

Mascarenhas MR, Mondick JT, Barrett JS, Stallings VA, Wilson MD, Schall JI. : Malabsorption Blood Test: Assessing Fat Absorption in Patients with Cystic Fibrosis and Pancreatic Insufficiency. J Clin Pharmacol. 55(8): 854-65, 2015.

Harskamp-van Ginkel MW, Hill KD, Becker K, Testoni D, Cohen-Wolkowiez M, Gonzalez D, Barrett JS, Benjamin DK Jr, Siegel DA, Banks P, Watt KM: Best Pharmaceuticals for Children Act–Pediatric Trials Network Administrative Core Committee. Drug Dosing in Overweight and Obese Children: A Systematic Review of Current Pharmacokinetic Data and Recommendations for Future Clinical Trials. JAMA Pediatr. 169(7): 678-85, 2015.

Zhang Y, Wei X, Bajaj G, Barrett JS, Meibohm B, Joshi A, Gupta M.: Challenges and considerations for development of therapeutic proteins in pediatric patients. J Clin Pharmacol. 55(Suppl 3): S103-15, 2015.

Van Rongen A, Vaughns JD, Moorthy G, Barrett JS, Knibbe CAJ, van den Anker JN. : Population pharmacokinetics of midazolam and its metabolites in overweight and obese adolescents. Br J Clin Pharmacol 80(5): 1185-96, 2015.

Ng CM, Dombrowsky E, Lin HP, Erlich ME, Moody DE, Barrett JS, Kraft WK. : Population Pharmacokinetic Model of Buprenorphine in Pediatric Patients with Neonatal Abstinence Syndrome. Pharmacotherapy 35(7): 670-80, 2015.

Huang Z, Barrett JS, Barrett K, Barrett R, Ng CM. : Novel Method to Predict Body Weight in Children Based on Age and Morphological Facial Features. J Clin Pharmacol. 55(4): 447-51, 2015.

Barrett JS. : Pediatric models in motion: Requirements for model-based decision support at the bedside British J Clin Pharmacol 79(1): 85-96, 2015.

back to top
Last updated: 04/04/2017
The Trustees of the University of Pennsylvania