Anne Rentoumis Cappola

faculty photo
Professor of Medicine
Attending Physician, Hospital of the University of Pennsylvania, Philadelphia, PA
Fellow, Institute on Aging, University of Pennsylvania School of Medicine
Member, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine
Member, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine
Associate Scholar, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine
Member, Cardiovascular Institute, University of Pennsylvania School of Medicine
Assistant Director, Institute for Translational Medicine and Therapeutics
Director, Clinical and Translational Research Center, renamed Center for Human Phenomic Research
Director, Clinical Research, Department of Medicine
Director, Medical Communication Research Institute
Department: Medicine

Contact information
Division of Endocrinology, Diabetes, and Metabolism
Room 12-136
Smilow Center for Translational Research, 12th floor
3400 Civic Center Blvd., Building 421
Philadelphia, PA 19104-5160
Office: (215) 746-6391
Fax: (215) 898-5408
Education:
B.A. (Biochemistry )
Harvard College (Advanced Standing), Cambridge, MA, 1990.
M.D.
University of Pennsylvania School of Medicine, 1994.
Sc.M. (Clinical Epidemiology)
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 2001.
Post-Graduate Training
Intern and Resident, Internal Medicine, Brigham and Women's Hospital, Boston, MA, 1994-1997.
Clinical Fellow, Endocrinology, Massachusetts General Hospital, Boston, MA, 1997-1998.
Clinical and Research Fellow, Endocrinology and Metabolism, Johns Hopkins Hospital, Baltimore, MD, 1998-2000.
Research Fellow, Center on Aging and Health, Johns Hopkins Medical Institutions, Baltimore, MD, 1999-2001.
Senior Honorary Visiting Fellow, University of Cambridge, Cambridge, UK, 2013-2014.
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Description of Research Expertise

Anne Rentoumis Cappola, M.D., Sc.M. is a Professor of Medicine in the Division of Endocrinology, Diabetes, and Metabolism; Director of the CTSA-sponsored Center for Human Phenomic Science; and Director of Clinical Research for the Department of Medicine. She is an Associate Editor for the Journal of the American Medical Association (JAMA).

Dr. Cappola leads an NIH-funded program focusing on the hormonal alterations that occur with aging and the clinical impact of these changes Current projects include studies defining cutoffs for thyroid dysfunction in older men and women; the role of thyroid hormone treatment in cardiovascular disease, hormonal treatments for the frailty syndrome; and metabolic changes in men and women who sustain a hip fracture.

Description of Itmat Expertise

Dr. Cappola's research focuses on the hormonal alterations that occur with aging and the clinical impact of these changes, including hormonal contributions to the frailty syndrome, and the clinical impact of subclinical thyroid disease in older individuals.

Selected Publications

van Vliet NA, van Heemst D, Almeida OP, Åsvold BO, Aubert CE, Bae JB, Barnes LE, Bauer DC, Blauw GJ, Brayne C, Cappola AR, Ceresini G, Comijs HC, Dartigues JF, Degryse JM, Dullaart RPF, van Eersel MEA, den Elzen WPJ, Ferrucci L, Fink HA, Flicker L, Grabe HJ, Han JW, Helmer C, Huisman M, Ikram MA, Imaizumi M, de Jongh RT, Jukema JW, Kim KW, Kuller LH, Lopez OL, Mooijaart SP, Moon JH, Moutzouri E, Nauck M, Parle J, Peeters RP, Samuels MH, Schmidt CO, Schminke U, Slagboom PE, Stordal E, Vaes B, Völzke H, Westendorp RGJ, Yamada M, Yeap BB, Rodondi N, Gussekloo J, Trompet S for the Thyroid Studies Collaboration: Association of thyroid dysfunction with cognitive function: an individual participant data analysis. JAMA Intern Med 181(11): 1440-1450, Nov 2021.

Shardell M, Cappola AR, Guralnik JM, Hicks GE, Kritchevsky SE, Simonsick EM, Ferrucci L, Semba RD, Shaffer NC, Harris T, Eiriksdottir G, Godnason V, Cotch MF, Orwoll E, Ensrud KE, Cawthon PM: Sex-specific 25-hydroxyvitamin D threshold concentrations for functional outcomes in older adults: PRoject on Optimal VItamin D in Older adults (PROVIDO). Am J Clin Nutr 114(1): 16-28, Jul 2021.

Cappola AR, Schriver ER, Mowery DL, Wollack C, Ives CT, Gonzales R, Cappella JN: Effect of targeted messaging on return to in-person visits during the COVID-19 pandemic: a randomized clinical trial. JAMA Netw Open 4(6): e2115211, Jun 2021.

Wade AN, Crowther NJ, Abrahams-Gessel S, Berkman L, George JA, Gómez-Olivé FX, Manne-Goehler J, Salomon JA, Wagner RG, Gaziano TA, Tollman SM, Cappola AR: Concordance between fasting plasma glucose and HbA1c in the diagnosis of diabetes in Black South African adults: a cross-sectional study. BMJ Open 11(6): e046060, Jun 2021.

Le NP, Varadhan R, Fried LP, Cappola AR: Cortisol and dehydroepiandrosterone response to ACTH and frailty in older women. J Gerontol A Biol Sci Med Sci 76(5): 901-905, April 2021.

Wildisen L, Del Giovane C, Moutzouri E. Betlinger S, Syrogiannouli L, Collet TH, Cappola A, Åsvold B, Bakker S, Yeap B, Aleida O, Ceresini G, Dullaart R, Ferrucci L, Grabe H, Jukema JW, Nauck M, Trompet S, Völzke H, Westendorp R, Gussekloo J, Klöppel S, Aujesky D, Bauer D, Peeters R, Feller M, Rodondi N : An individual participant data analysis of prospective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms. Sci Rep 10(1): 19111, Nov 2020.

Zhou W, Brumpton B, Kabil O, Gudmundsson J, Thorleifsson G, Weinstock J, Zawistowski M, Nielsen JB, Chaker L, Medici M, Teumer A, Naitza S, Sanna S, Schultheiss UT, Cappola A, Karjalainen J, Kurki M, Oneka M, Taylor P, Fritsche LG, Graham SE, Wolford BN, Overton W, Rasheed H, Haug EB, Gabrielsen ME, Skogholt AH, Surakka I, Davey Smith G, Pandit A, Roychowdhury T, Hornsby WE, Jonasson JG, Senter L, Liyanarachchi S, Ringel MD, Xu L, Kiemeney LA, He H, Netea-Maier RT, Mayordomo JI, Plantinga TS, Hrafnkelsson J, Hjartarson H, Sturgis EM, Palotie A, Daly M, Citterio CE, Arvan P, Brummett CM, Boehnke M, de la Chapelle A, Stefansson K, Hveem K, Willer CJ, Åsvold BO: GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer. Nat Commun 11(1): 3981, Aug 2020.

Wildisen L, Moutzouri E, Beglinger S, Syrogiannouli L, Cappola AR, Åsvold BO, Bakker SJL, Ceresini G, Dullaart R, Ferrucci L, Grabe H, Jukema JW, Nauck M, Trompet S, Völzke H, Westendorp RGJ, Gussekloo J, Peeters RP, Klöppel S, Aujesky D, Bauer DC, Rodondi N, Del Giovane C, Feller M; Thyroid Studies Collaboration: Subclinical thyroid dysfunction and depressive symptoms: protocol for a systematic review and individual participant data meta-analysis of prospective cohort studies. BMJ Open 9(7): e029716, Jul 2019.

Meuwese CL, van Diepen M, Cappola AR, Sarnak MJ, Shlipak MG, Bauer DC, Fried LP, Iacoviello M, Vaes B, Degryse J, Khaw KT, Luben RN, Asvold BO, Bjoro T, Vatten LJ, de Craen AJM, Trompet S, Iervasi G, Molinaro S, Cersini G, Ferrucci L, Dullaart RPF, Bakker SJL, Jukema JW, Kearney PM, Stott DJ, Peeters RP, Franco OH, VOlzke H, Walsh JP, Bremner A, Sgarbi JA, Maciel RMB, Imaizumi M, Ohishi W, Dekker FW, Rodondi N, Gussekloo J, den Elzen WPJ for the Thyroid Studies Collaboration: Low thyroid function is not associated with an accelerated deterioration in renal function. Nephrol Dial Transplant 34(4): 650-659, Apr 2019.

Ellervik C, Roselli C, Christophersen IE, Alonso A, Pietzner M, Sitlani CM, Trompet S, Arking DE, Geelhoed B, Guo X, Kleber ME, Lin HJ, Lin H, Macfarlane P, Selvin E, Shaffer C, Smith AV, Verweij N, Weiss S, Cappola AR, Dörr M, Gudnason V, Heckbert S, Mooijaart S, Marz W, Psaty BM, Ridker PM, Roden D, Stott DJ, Völzke H, Benjamin EJ, Delgado G, Ellinor P, Homuth G, Köttgen A, Jukema JW, Lubitz SA, Mora S, Rienstra M, Rotter JI, Shoemaker MB, Sotoodehnia N, Taylor KD, van der Harst P, Albert CM, Chasman DI : Assessment of the relationship between genetic determinants of thyroid function and atrial fibrillation: a Mendelian randomization study. JAMA Cardiol 4(2): 144-152, Feb 2019.

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Last updated: 12/01/2021
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