Anne Rentoumis Cappola

faculty photo
Professor of Medicine (Endocrinology, Diabetes and Metabolism)
Attending Physician, Hospital of the University of Pennsylvania, Philadelphia, PA
Fellow, Institute on Aging, University of Pennsylvania School of Medicine
Member, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine
Member, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine
Member, Cardiovascular Institute, University of Pennsylvania School of Medicine
Executive Director, Penn Medical Communication Research Institute
Director, Division of Geroscience, Gerontology, and Geriatrics, Institute on Aging, University of Pennsylvania School of Medicine
Department: Medicine

Contact information
Division of Endocrinology, Diabetes, and Metabolism
Room 12-136
Smilow Center for Translational Research, 12th floor
3400 Civic Center Blvd., Building 421
Philadelphia, PA 19104-5160
Office: (215) 746-6391
Fax: (215) 898-5408
Education:
B.A. (Biochemistry )
Harvard College (Advanced Standing), Cambridge, MA, 1990.
M.D.
University of Pennsylvania School of Medicine, 1994.
Sc.M. (Clinical Epidemiology)
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 2001.
Post-Graduate Training
Intern and Resident, Internal Medicine, Brigham and Women's Hospital, Boston, MA, 1994-1997.
Clinical Fellow, Endocrinology, Massachusetts General Hospital, Boston, MA, 1997-1998.
Clinical and Research Fellow, Endocrinology and Metabolism, Johns Hopkins Hospital, Baltimore, MD, 1998-2000.
Research Fellow, Center on Aging and Health, Johns Hopkins Medical Institutions, Baltimore, MD, 1999-2001.
Senior Honorary Visiting Fellow, University of Cambridge, Cambridge, UK, 2013-2014.
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Description of Research Expertise

Anne Rentoumis Cappola, M.D., Sc.M. is a Professor of Medicine in the Division of Endocrinology, Diabetes, and Metabolism and Exeutive Director of the Penn Medical Communication Research Institute (PMCRI). She is an Associate Editor for the Journal of the American Medical Association (JAMA).

Dr. Cappola leads an NIH-funded program focusing on the hormonal alterations that occur with aging and the clinical impact of these changes Current projects include studies defining cutoffs for thyroid dysfunction in older men and women; the role of thyroid hormone treatment in cardiovascular disease, hormonal treatments for the frailty syndrome; and metabolic changes in men and women who sustain a hip fracture.

Description of Itmat Expertise

Dr. Cappola's research focuses on the hormonal alterations that occur with aging and the clinical impact of these changes, including hormonal contributions to the frailty syndrome, and the clinical impact of subclinical thyroid disease in older individuals.

Selected Publications

Hwang S, Reddy S, Wainwright K, Schriver E, Cappola AR, Mowery D: Using natural language processing to extract and classify symptoms among patients with thyroid dysfunction. Stud Health Technol Inform 310: 614-618, Jan 2024.

Teumer A, Sterenborg R, Steinbrenner I, Li Y, Bujnis M, Naito T, Marouli E, Galesloot T, Babajide O, Andreasen L, Astrup A, Åsvold BO, Bandinelli S, Beekman M, Beilby J, Bork-Jensen J, Boutin T, Brody J, Brown S, Brumpton B, Campbell P, Cappola AR, Ceresini G, Chaker L, Chasman D, Concas MP, de Almeida RC, Cross S, Cucca F, Deary I, Kjaergaard A, Tcheugui JE, Ellervik C, Eriksson J, Ferrucci L, Freudenberg J, Fuchsberger C, Gieger C, Giulianini F, Gögele M, Graham S, Grarup N, Gunjača I, Hansen T, Harding B, Harris S, Haunsø S, Hayward C, Hui J, Ittermann T, Jukema JW, Kajantie E, Kanters J, Kårhus L, Kiemeney L, Kloppenburg M, Kühnel B, Lahti J, Langenberg C, Lapauw B, Leese G, Li S, Liewald D, Linneberg A, Lominchar J, Luan J, Martin N, Matana A, Meima M, Meitinger T, Meulenbelt I, Mitchell B, Møllehave L, Mora S, Naitza S, Nauck M, Netea-Maier R, Noordam R, Nursyifa C, Okada Y, Onano S, Papadopoulou A, Palmer C, Pattaro C, Pedersen O, Peters A, Pietzner M, Polasek O, Pramstaller P, Psaty B, Punda A, Ray D, Redmond P, Richards JB, Ridker P, Russ T, Ryan K, Olesen M, Schultheiss U, Selvin E, Siddiqui M, Sidore C, Slagboom PE, Sorensen T, Soto-Perdre E, Spector T, Spedicati B, Srinivasan S, Starr J, Stott D, Tanaka T, Torlak V, Trompet S, Tuhkanen J, Uitterlinden A, van den Akker E, van den Eynde T, van der Klauw M, van Heemst D, Verroken C, Visser WE, Vojinovic D, Völzke H, Waldenberger M, Walsh J, Wareham N, Weiss S, Willer C, Wilson S, Wolffenbuttel B, Wouters H, Wright M, Yang Q, Zemunik T, Zhou W, Zhu G, Zöllner S, Smit J, Peeters R, Köttgen A, Medici M: Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications Nat Commun 15(1): 888, Jan 2024.

Xu Y, Derakhshan A, Hysaj O, Wildisen L, Ittermann T, Pingitore A, Abolhassani N, Medici M, Kiemeney LALM, Riksen NP, Dullaart RPF, Trompet S, Dörr M, Brown SJ, Schmidt B, Führer-Sakel D, Vanderpump MPJ, Muendlein A, Drexel H, Fink HA, Ikram MK, Kavousi M, Rhee CM, Bensenor IM, Azizi F, Hankey GJ, Iacoviello M, Imaizumi M, Ceresini G, Ferrucci L, Sgarbi JA, Bauer DC, Wareham N, Boelaert K, Bakker SJL, Jukema JW, Vaes B, Iervasi G, Yeap BB, Westendorp RGJ, Korevaar TIM, Völzke H, Razvi S, Gussekloo J, Walsh JP, Cappola AR, Rodondi N, Peeters RP, Chaker L; Thyroid Studies Collaboration: The optimal healthy ranges of thyroid function defined by the risk of cardiovascular disease and mortality: systematic review and individual participant data meta-analysis. Lancet Diab Endocrinol 11(10): 743-754, Oct 2023.

Alwan H, Villoz F, Feller M, Dullaart RPF, Bakker SJL, Peeters RP, Kavousi M, Bauer DC, Cappola AR, Yeap BB, Walsh JP, Brown SJ, Ceresini G, Ferrucci L, Gussekloo J, Trompet S, Iacoviello M, Moon JH, Razvi S, Benseñor IM, Azizi F, Amouzegar A, Valdés S, Colomo N, Wareham NJ, Jukema JW, Westendorp RGJ, Kim KW, Rodondi N, Del Giovane C: Subclinical thyroid dysfunction and incident diabetes: a systematic review and an individual participant data analysis of prospective cohort studies. Eur J Endocrinol 187(5): S35-S46, Sept 2022.

Brown RT, Diaz-Ramirez LG, Boscardin WJ, Cappola AR, Lee SJ, Steinman MA: Changes in the hierarchy of functional impairment from middle age to older age. J Gerontol A Biol Sci Med Sci 77(8): 1577-1584, Aug 2022.

Orwig DL, Abraham DS, Hochberg MC, Gruber-Baldini A, Guralnik JM, Cappola AR, Golden J, Hicks GE, Miller RR, Resnick B, Shardell M, Sterling RS, Magaziner J: Sex differences in recovery across multiple domains among older adults with hip fracture. J Gerontol A Biol Sci Med Sci 77(7): 1463-1471, Jul 2022.

Friedman AB, Chen AT, Wu R, Coe NB, Halpern S, Hwang U, Kelz R, Cappola AR: Evaluation and disposition of older adults presenting to the emergency department with abdominal pain. J Am Geriatr Soc 70(2): 501-511, Feb 2022.

Syrogiannouli L, Wildisen L, Meuwese C, Bauer DC, Cappola AR, Gussekloo J, Den Elzen W, Trompet S, Westendorp RG, Jukema JW, Ferrucci L, Ceresini G, Åsvold BO, Chaker L, Peeters RP, Imaizumi M, Ohishi W, Vaes B, Völzke H, Sgarbi JA, Walsh JP, Dullaart RP, Bakker SJ, Iacoviello M, Rodondi N, Del Giovane C: Incorporating baseline outcome data in individual participant data meta-analysis of non-randomized studies. Front Psychiatry 13: 774251, Feb 2022.

Gregson CL, Madanhire T, Rehman A, Ferrand RA, Cappola AR, Tollman S, Mokoena T, Mickelsfield LK, Wade AN, Fabian J: Osteoporosis, rather than sarcopenia, is the predominant musculoskeletal disease in rural South Africa where HIV prevalence is high: a cross-sectional study. J Bone Miner Res 37(2): 244-255, Feb 2022.

van Vliet NA, van Heemst D, Almeida OP, Åsvold BO, Aubert CE, Bae JB, Barnes LE, Bauer DC, Blauw GJ, Brayne C, Cappola AR, Ceresini G, Comijs HC, Dartigues JF, Degryse JM, Dullaart RPF, van Eersel MEA, den Elzen WPJ, Ferrucci L, Fink HA, Flicker L, Grabe HJ, Han JW, Helmer C, Huisman M, Ikram MA, Imaizumi M, de Jongh RT, Jukema JW, Kim KW, Kuller LH, Lopez OL, Mooijaart SP, Moon JH, Moutzouri E, Nauck M, Parle J, Peeters RP, Samuels MH, Schmidt CO, Schminke U, Slagboom PE, Stordal E, Vaes B, Völzke H, Westendorp RGJ, Yamada M, Yeap BB, Rodondi N, Gussekloo J, Trompet S for the Thyroid Studies Collaboration: Association of thyroid dysfunction with cognitive function: an individual participant data analysis. JAMA Intern Med 181(11): 1440-1450, Nov 2021.

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Last updated: 04/29/2024
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