Max B. Kelz

faculty photo
David E. Longnecker Associate Professor of Anesthesiology and Critical Care
Member, Mahoney Institute of Neurological Sciences, University of Pennsylvania
Member, Penn Genomics Institute, University of Pennsylvania
Member, Institute for Translational Medicine and Therapeutics
Member, Center for Sleep and Circadian Neurobiology, University of Pennsylvania
Chair of Admissions, Department of Neuroscience MD PhD program, University of Pennsylvania, Perelman School of Medicine
MSTP Program Advisor, University of Pennsylvania
Director for Research Education, Department of Anesthesiology, University of Pennsylvania, Perelman School of Medicine
Member, Committee on Appointments and Promotions, Department of Anesthesiology, University of Pennsylvania
Education Council Member, Children's Hospital of Philadelphia, Department of Anesthesiology
Ombudsman, Department of Anesthesiology and Critical Care, University of Pennsylvania
Department: Anesthesiology and Critical Care

Contact information
3620 Hamilton Walk,
John Morgan Building - Room 334
Philadelphia, PA 19104
Office: 215 573-8208
Fax: 215 349-5078
Lab: 215 898-8929
Graduate Group Affiliations
MS (Molecular Biophysics and Biochemistry)
Yale University, 1993.
BS (Molecular Biophysics and Biochemistry)
Yale University, 1993.
PhD (Neuroscience)
Yale University, 1999.
MD (Medicine)
Yale University, 2000.
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Description of Research Expertise

Molecular Mechanisms of Anesthetic Action
Neurobiology of Sleep Wake Regulation
Mouse Genetics
Molecular Biology
Anesthetic pharmacology

Description of Itmat Expertise

Dr. Kelz studies the systems neuroscience of arousal paying special attention to the neuronal substrates that mediate anesthetic action.

Selected Publications

Wasilczuk AZ, Proekt A, Kelz MB, McKinstry-Wu AR.: High-density Electroencephalographic Acquisition in a Rodent Model Using Low-cost and Open-source Resources. J Vis Exp. 117: e54908, Nov 2016.

Erickson RL, Terzi MC, Jaber SM, Hankenson FC, McKinstry-Wu A, Kelz MB, Marx JO.: Intraperitoneal Continuous-Rate Infusion for the Maintenance of Anesthesia in Laboratory Mice (Mus musculus). J Am Assoc Lab Anim Sci. 55(5): 548-57, September 2016.

Gardner B, Strus E, Meng QC, Coradetti T, Naidoo NN, Kelz MB, Williams JA.: Sleep Homeostasis and General Anesthesia: Are Fruit Flies Well Rested after Emergence from Propofol? Anesthesiology 124(2): 404-16, Feb 2016.

Drobish JK, Kelz MB, DiPuppo P, Cook-Sather SD: Case report: Emergence delirium with transient associative agnosia and expressive aphasia reversed by flumazenil in a pediatric patient. Anesthesia & Analgesia Case Reports 11(4): 148-150, June 2015.

McCarren HS, Chalifoux MR, Han B, Moore JT, Meng QC, Baron-Hionis N, Sedigh-Sarvestani M, Contreras D, Beck SG, Kelz MB: α2-Adrenergic Stimulation of the VLPO Destabilizes the Anesthetic State. Journal of Neuroscience 34(49): 16385-96, Dec 2014.

Han B, McCarren HS, O'Neill D, Kelz MB: Distinctive Recruitment of Endogenous Sleep-promoting Neurons by Volatile Anesthetics and a Nonimmobilizer. Anesthesiology 121(5): 999-1009, Nov 2014.

Jaber SM, Hankenson FC, Heng K, McKinstry-Wu A, Kelz MB, Marx JO: Dose regimens, variability, and complications associated with using repeat-bolus dosing to extend a surgical plane of anesthesia in laboratory mice. J Am Assoc Lab Anim Sci. 53(6): 684-91, Nov 2014.

Deutschman CS, Raj NR, McGuire EO, Kelz MB: Orexinergic Activity Modulates Altered Vital Signs and Pituitary Hormone Secretion in Experimental Sepsis. Critical Care Medicine 41(11): e368-75, Nov 2013.

McCarren HS, Moore JT, Kelz MB: Assessing changes in volatile general anesthetic sensitivity of mice after local or systemic pharmacological intervention JoVE 80: e51079, October 2013.

Joiner WJ, Friedman EB, Hung H-T, Koh K, Sowcik M, Sehgal A, Kelz MB: Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsiveness. PLoS Genetics 9(9): e1003605, September 2013 Notes: Published with an editorial by Sanders RD and Maze M: Take Off, Landing, and Fly Anesthesia PLoS Genetics 9(9): e1003788, 2013.

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Last updated: 04/24/2017
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