Rong Zhou

faculty photo
Research Associate Professor of Radiology
Member, Institute of Regenerative Medicine, University of Pennsylvania
Member, Institute of Translational Medicine and Therapeutics (ITMAT) , University of Pennsylvania
Full Member of the Abramson Cancer Center, ACC of the University of Pennsylvania
Department: Radiology

Contact information
198 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104
Office: (215)-746-8747
Fax: 215-573-2113
Lab: (215)-746-8752
BS (Biomedical Engineering)
Shanghai Jiao Tong University, 1987.
PhD (Biophysics /Magnetic Resonance)
State University of New York at Buffalo, 1998.
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Description of Research Expertise

Magnetic resonance imaging (MRI) and spectroscopy (MRS)
Developing imaging markers (MRI/S and PET) of metabolic signatures of cancer and heart failure.
Developing in vivo imaging markers for assessing therapeutic responses.
Stem cells and cardiac repair

Description of Itmat Expertise

Dr. Zhou is directing a Cardiovascular Imaging Program focusing on small animal models. Within this program, an array of non-invasive imaging techniques have been developed /optimized on small animals including in vivo left ventricular global function, wall motion, and myocardial blood flow estimated by arterial spin labeling and DCE-MRI combined with kinetic modeling.

This program has been funded by NIH and Sate of Pennsylvania to examine stem cell-based myocardial regeneration in preclinical models. Her laboratory is able to generate highly enriched cardiomyocytes derived from murine embryonic stem cells in large quantities for in vivo studies. Her laboratory is developing molecular imaging techniques including PET and MRI/S combined with nanoparticles and reporter gene approaches for studying cardiovascular diseases as well as cancers with an emphasis on metabolic signatures of these diseases.

Selected Publications

Zhou R*, Bagga P, Nath K, Hariharan H, Mankoff DA and Reddy R*: Glutamate-weighted Chemical Exchange Saturation Transfer (GluCEST) Magnetic Resonance Imaging Detects Glutaminase Inhibition in a Mouse Model of Triple Negative Breast Cancer. Cancer Research Epub ahead of print, August 2018 Notes: * corresponding author.

Zhou R*, Pantel AR, Li S, Lieberman BP, Ploessl K, Choi H, Blankemeyer E, Lee H, Kung HF, Mach RH, Mankoff DA*: [18F](2S,4R)4-Fluoroglutamine PET Detects Glutamine Pool Size Changes in Triple Negative Breast Cancer in Response to Glutaminase Inhibition. Cancer Research 77(6): 1476-1484, 2017 Notes: *Corresponding author.

Zhou R, Bansal N, Leeper DB, Glickson JD : Intracellular acidification of human melanoma xenografts by respiratory inhibitor meta-iodobenzylguanidine plus hyperglycemia: a 31P magnetic resonance spectroscopy study. Cancer Research 60: 3532-3536, 2000.

Zhou R, Mazurchuk R, and Straubinger RM: Anti-vasculature effects of doxorubicin-containing liposomes in an intracranial rat brain tumor model. Cancer Research 62: 2561-2566, 2002.

Choi H, Liu T, Nath K, Zhou R* and Chen IW*: Peptide nanoparticle with pH-sensing cargo solubility enhances cancer drug efficiency. Nano Today (Impact Factor =17) 13: 15-22, 2017 Notes: * Corresponding authors.

Liu T, Choi H, Zhou R* and Chen I*: RES Blockade: A Strategy for Boosting Efficiency of Nanoparticle Drug. Nano Today (Impact Factor = 17) 10: 11-21, 2015 Notes: *Corresponding author.

Zhou R, Acton PD, Ferrari VA: Imaging Stem Cells Implanted in Infarcted Myocardium. Journal of American College of Cardiology 48(10): 2094-2106, 2006.

Qiao H, Zhang H, Zheng Y, Ponde DE, Shen D, Gao F, Bakken A, Schmitz A, Kung HF, Ferrari VA, and Zhou R: Embryonic Stem Cell Grafting in Normal and Infarcted Myocardium: Serial Assessment with MR Imaging and PET Dual Detection. Radiology 250(3): 821-829, 2009.

Zhang H, Qiao H, Frank RS, Huang B, Propert KJ, Margulies S, Ferrari VA, Epstein JA, Zhou R. : Spin-Labeling Magnetic Resonance Imaging Detects Increased Myocardial Blood Flow After Endothelial Cell Transplantation in the Infarcted Heart. Circulation: Cardiovascular Imaging. 5: 210-217, 2012.

Qiao H, Zhang H, Yamanaka S, Patel VV, Petrenko NB, Huang B, Muenz LR, Ferrari VA, Boheler KR and Zhou R: Long-term Improvement in Post-Infarct Left Ventricular Global and Regional Contractile Function Mediated by Embryonic Stem Cell-Derived Cardiomyocytes. Circulation: Cardiovascular Imaging 4(1): 33-41, 2011.

Zhou R, Idiyatullin D, Moeller S, Corum C, Zhang H, Qiao H, Zhong J, Garwood M : SWIFT Detection of SPIO Labeled Stem Cells Grafted in the Myocardium. Magnetic Resonance in Medicine 63: 1154-1161, 2010.

Li LZ*, Zhou R*, Xu HN, Moon L, Zhong T, Kim EJ, Qiao H, Reddy R, Leeper D, Chance B, Glickson JD.: Quantitative magnetic resonance and optical imaging biomarkers of melanoma metastatic potential. Proc Natl Acad Sci USA 106(16): 6608-13, 2009 Notes: *equal contributing 1st authors.

Zhou R, Thomas DT, Qiao H, Bal H, Choi SR, Alavi A, Ferrari VA, Kung HF and Acton PD.: In vivo Detection of Stem Cells Grafted in the Infarcted Rat Myocardium. Journal of Nuclear Medicine 46: 816-822, 2005.

Zhou R, Pickup S, Yankeelov T, Springer Jr. CS, Glickson JD : Simultaneous measurement of AIF and tumor pharmacokinetics in mice by dynamic contrast enhanced imaging: effects of transcytolemmal water exchange. Magnetic Resonance in Medicine 52: 248-257, 2004.

Zhou R, Steve Pickup, Jerry Glickson, Craig Scott and Victor Ferrari : Assessment of Global and Regional Myocardial Function in the Mouse Using Cine and Tagged MRI. Magnetic Resonance in Medicine 49: 760-764, 2003.

Kostetskii I, Li J, Xiong Y, Zhou R, Ferrari VA, Patel VV, Molkentin JD, Radice GL: Induced deletion of the N-Cadherin gene in the heart leads to dissolution of the intercalated disc structure. Circulation Research 96: 346-354, 2005.

Kook H, Lepore JJ, Gitler AD, Lu MM, Wing-Man Yung W, Mackay J, Zhou R, Ferrari V, Gruber P, and Epstein JA: Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop. Journal of Clinical Investigation 112: 863-871, 2003.

Abtahian F, Guerriero A, Lu M, Zhou R, Mocsai A, Myers E, Huang B, Jackson D, Ferrari VA, Tybulewicz V, Lowell CA, Lepore JJ, Koretzky GA, and Kahn M: Separation of blood and lymphatic vascular networks is regulated by the hematopoietic signaling proteins SLP-76 and SYK. Science 299: 247-251, 2003.

Auricchio A, Zhou R, Wilson J, Glickson J: In vivo detection of gene expression in liver by 31P nuclear magnetic resonance spectroscopy employing creatine kinase as a marker gene. Proceeding of National Academy of Science (USA) 98: 5205-5210, 2001.

Lowell AN, Qiao H, Liu T, Ishikawa T, Zhang H, Oriana S, Wang M, Ricciotti E, FitzGerald GA, Zhou R* and Yamakoshi Y* : Functionalized Low-Density Lipoprotein Nanoparticles for in Vivo Enhancement of Atherosclerosis on Magnetic Resonance Images. Bioconjugate Chemistry 23: 2313-2319, 2012 Notes: *Corresponding author.

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Last updated: 12/10/2018
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