Eric Lancaster

faculty photo
Assistant Professor of Neurology at the Hospital of the University of Pennsylvania
Department: Neurology
Graduate Group Affiliations

Contact information
3 W. Gates - Neurology
3400 Spruce St.
Philadelphia, PA 19104
Office: 215 200 7646
Fax: 215 349 5579
Lab: 215 898 0181
Education:
BS (Biomedical Engineering)
The Johns Hopkins University, 1994.
PhD (Neuroscience)
The University of Maryland, 2002.
MD (medicine)
The University of Maryland, 2003.
Post-Graduate Training
Medical Internship, The Hosptial of the University of Pennsylvania, 2003-2004.
Neurology Residency, The University of Pennsyvlania, 2004-2007.
Neuromuscular clinical fellowship, The University of Pennsylvania, 2007-2008.
Neuromuscular research fellowship, The University of Pennsylvania, 2008-2010.
Permanent link
 
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Description of Research Expertise

Neuronal autoantibodies, encephalitis, acquired neuromyotonia (Isaacs' syndrome), peripheral nerve hyperexcitability, potassium channels, the glycine receptor, the GABA-B receptor, neuromuscular disorders, stiff person syndrome.

Description of Itmat Expertise

I am interested in autoimmunity to brain and peripheral nerve proteins. I treat patients with autoimmune disorders in my clinic and try to figure out how their autoimmune diseases work in my lab.

Selected Publications

Argent L, Winter F, Prickett I, Carrasquero-Ordaz M, Olsen AL, Kramer H, Lancaster E, Becker EBE.: Caspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor in the developing cerebellum and regulates Purkinje cell morphology. Journal of Biological Chemistry 295(36): 12716-12726, September 2020.

Tizazu E, Ellis CA, Reichert J, Lancaster E.: Low rate of glutamic acid decarboxylase 65 (GAD-65) antibodies in chronic epilepsy. Seizure 80: 38-41, August 2020.

Stadtmauer EA, Fraietta JA, Davis MM, Cohen AD, Weber KL, Lancaster E, Mangan PA, Kulikovskaya I, Gupta M, Chen F, Tian L, Gonzalez VE, Xu J, Jung IY, Melenhorst JJ, Plesa G, Shea J, Matlawski T, Cervini A, Gaymon AL, Desjardins S, Lamontagne A, Salas-Mckee J, Fesnak A, Siegel DL, Levine BL, Jadlowsky JK, Young RM, Chew A, Hwang WT, Hexner EO, Carreno BM, Nobles CL, Bushman FD, Parker KR, Qi Y, Satpathy AT, Chang HY, Zhao Y, Lacey SF, June CH.: CRISPR-engineered T cells in patients with refractory cancer. Science 367(6481): eaba7365, February 2020.

Dalmau J, Armangué T, Planagumà J, Radosevic M, Mannara F, Leypoldt F, Geis C, Lancaster E, Titulaer MJ, Rosenfeld MR, Graus F.: An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models. Lancet Neurology 18(11): 1045-1057, November 2019.

Gill A, Perez MA, Perrone CM, Bae CJ, Pruitt AA, Lancaster E.: A case series of PD-1 inhibitor-associated paraneoplastic neurologic syndromes. J Neuroimmunol. 334: 576980, June 2019.

Lancaster E, Burnor E, Zhang J, Lancaster E.: ADAM23 is a negative regulator of Kv1.1/Kv1.4 potassium currents. Neurosci Lett.(704), 159-163, April 2019.

Lancaster E.: Encephalitis, severe seizures, and multifocal brain lesions: Recognizing autoimmunity to the GABAA receptor. Neurol Neuroimmunol Neuroinflamm. 6(3): 554, April 2019.

Cohen AD, Garfall AL, Stadtmauer EA, Melenhorst JJ, Lacey SF, Lancaster E, Vogl DT, Weiss BM, Dengel K, Nelson A, Plesa G, Chen F, Davis MM, Hwang WT, Young RM, Brogdon JL, Isaacs R, Pruteanu-Malinici I, Siegel DL, Levine BL, June CH, Milone MC.: B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma. J Clin Invest. (130), 126397, March 2019.

Patterson K, Iglesias E, Nasrallah M, González-Álvarez V, Suñol M, Anton J, Saiz A, Lancaster E, Armangue T.: Anti-MOG encephalitis mimicking small vessel CNS vasculitis. Neurol Neuroimmunol Neuroinflamm. 6(2): e538, February 2019.

Amado DA, Rieders JM, Diatta F, Hernandez-Con P, Singer A, Mak JT, Zhang J, Lancaster E, Davidson BL, Chen-Plotkin AS.: AAV-Mediated Progranulin Delivery to a Mouse Model of Progranulin Deficiency Causes T Cell-Mediated Toxicity. Mol Ther. 27(2): 465-478, February 2019.

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Last updated: 11/05/2020
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