Leslie Raffini

faculty photo
Associate Professor of Pediatrics at the Children's Hospital of Philadelphia
Director, Hemostasis and Thrombosis Center, Children's Hospital of Philadelphia
Department: Pediatrics

Contact information
The Children's Hospital of Philadelphia
Division of Hematology
3501 Civic Center Blvd
CTRB 11th Floor
Philadelphia, PA 19104
Office: 267 426-5029
B.S. (Molecular Biology)
University of Wisconsin, 1991.
University of Wisconsin, 1996.
M.S. (Clinical Epidemiology)
University of Pennsylvania, 2005.
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Description of Research Expertise

Risk Factors for Thromboembolic Events in Children

Description of Other Expertise

Diagnosis and Management of Bleeding Disorders in Children

Description of Itmat Expertise

Dr. Raffini's field of interest is clinical research in pediatric hemostasis and thrombosis.

Selected Publications

Ragni M, Fogarty P, Josephson N, Neff A, Raffini L, Kessler C.: Survey of current prophylaxis practice and bleeding characteristics of hemophilia children in U.S. Hemophilia Treatment Centers. Haemophilia 18(1): 63-68, 2012.

Raffini, L.: Thromboembolic events in Children Consultative Hemostasis and Thrombosis. Kitchen, C. (eds.). Elsevier Health Sciences, 2012.

Peutz J, Huang Y-S, Witmer C, Raffini L: Widespread use of fresh frozen plasma in U.S. Children's Hospitals despite limited evidence demonstrating a beneficial effect. J Pediatr 160(2): 210-215, 2012.

Raffini L, Trimarchi T, Beliveau J, Davis D: Thromboprophylaxis in a pediatric hospital: a patient safety and quality improvement initiative. Pediatrics 127: e1326-1332, 2011.

Witmer C, Huang Y-S, Lynch K, Raffini L, Shah S: Off label recombinant factor VIIa use in pediatric: A multicenter cohort study. J Pediatr 158: 820-825, 2011.

Gentilomo C, Huang Y-S, Raffini L. : Significant increase in clopidogrel use is U.S. Children’s hospitals. Pediatr Cardiol 32: 167-172, 2011.

Witmer C, Presley R, Kulkarni R, Soucie M, Manno C, Raffini L. : Associations between intracranial hemorrhage and prescribed prophylaxis in a large cohort of hemophilia patients in the United States. Br J Haematol 152: 211-216, 2011.

Young G, Boshkov L, Sullivan J, Raffini L, Cox D, Boyle D, Kallender H, Tarka E, Soffer J, Hursting M.: Argatroban therapy in pediatric patients requiring non-heparin anticoagulation: An open-label safety, efficacy, and pharmacokinetic study. Pediatr Blood Cancer 56(7): 1103-1109, 2011.

Raffini L: Hereditary Predisposition to Thrombosis, Thrombotic Disorders in Children, Antithrombotic Therapy. Nelson's Textbook of Pediatrics, 19th Edition. Elsevier Health Sciences, 2010.

Kenet G, Lukhoff L, Albisetti M, Bernard T, Bonduel M, Brandao L, Chabrier S, Chan A, Cowan F, Fiedler B, Fullerton H, Ganesan V, Goldenberg N, Golumb M, Grabowski E, Heller C, Holzhaur S, Iorio A, Journeycake J, Kirkham F, Kurnik K, Lynch J, Male C, Manco-Johnson M, Mesters R, Monagle P, van Ommen H, Raffini L, Simioni P, Strater R, Young G, Nowak-Gottle U. : Impact of thrombophilia on arterial ischemic stroke or cerebral sinovenous thrombosis in children: A systematic review and meta-analysis of observational studies. Circulation 121: 1838-47, 2010.

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Last updated: 08/03/2012
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