Jose L. Pascual L.

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Associate Professor of Surgery at the Hospital of the University of Pennsylvania and the Presbyterian Medical Center of Philadelphia
Attending Surgeon, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending Intensivist, Penn e-lert eICU, Philadelphia, PA
Attending Surgeon, Penn Presbyterian Medical Center, Philadelphia, PA
Attending Surgical Intensivist, Pennsylvania Hospital, Philadelphia, PA
Clinical Associate , University of Pennsylvania School of Nursing
Patient Safety Officer , Department of Surgery, University of Penn Hospital
Attending Intensivist, Philadelphia Veteran’s Affairs Medical Center, Phila. PA, University of Pennsylvania
Co-medical Director , Surgical ICU, Hospital of the University of Pennsylvania
Reviewer , Penn Acute Research Collaborative (PARC) reviewer
Department: Surgery

Contact information
Division of Trauma & Surgical Critical Care
Perelman School of Medicine at the University of Pennsylvania
51 North 39th St,MOB 1st floor, Suite 120, Room 108
Philadelphia, PA 19104
Office: 215-662-7323
Fax: 215-243-4679
N/A (Physiology)
McGill University, Montreal, Quebec , 1990.
N/A (Biochemistry)
University of Ottawa, Ottawa, Ontario , 1992.
University of Ottawa, Ottawa, Ontario, 1996.
McGill University, Montreal, Quebac, 2005.
McGill University, Montreal, Quebec, 2005.
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Description of Research Expertise

Jose Pascual is a clinical surgeon specialized in trauma and critical care who has a special interest in shock and head injury. His research interests are shared in basic science research where he evaluates, in vivo, through intravital microscopy the real time microcirculation of pia on live rodent brains. He seeks to learn how a variety of insults including head injury and shock affect the microcirculation and how different management strategies influence these changes. This basic science work is translated into several clinical projects both retrospective and prospective evaluating the effects of different osmotherapeutic agents in traumatic brain injured patients as well as the immunemodulating effects of different resuscitation fluids in different forms of shock.

Description of Itmat Expertise

Traumatic brain injury
Osmotherapy for intracranial hypertension.
Hemorhhagic shock resuscitation
Immunemodulation in resuscitation
Hypertonic resuscitation
Neutropil endothelial interactions
Simulation in pedagogical methods for mediacal/surgical education

Selected Publications

Moore S, Weiss B, Pascual JL, Kaplan LJ.: Management of Acute Respiratory Failure in the Patient with Sepsis or Septic Shock. Surg Infect (Larchmt). Feb/Mar 2018.

Nagata K, Suto Y, Cognetti J, Browne KD, Kumasaka K, Johnson VE, Kaplan L, Marks J, Smith DH, Pascual JL.: Early Non-anticoagulant Desulfated Heparin After TBI: Reduced Brain Edema and Leukocyte Mobilization is Associated with Improved Watermaze Learning Ability Weeks After Injury. J Trauma Acute Care Surg Jan 2018.

Nagata K, Suto Y, Cognetti J, Browne KD, Kumasaka K, Johnson V, Kaplan L, Marks JA, Smith DH, Pascual JL.: Non-Anticoagulant desulfated heparin acutely reduces leukocyte mobilization and brain edema and improves watermaze learning ability weeks after traumatic brain injury. Podium presentation at the 76th Annual Meeting of the American Association for the Surgery of Trauma, Baltimore, MD. Sept 2017.

Sherma A, Sinha S, Oselkin M, Pascual J, Schuster J,: External carotid pseudoaneurysm due to wound vacuum placement after self-inflicted shotgun blast to face. Podium at 3rd Annual Critical Care Spectacular Case Presentation Competition, Philadelphia Drinker Society,Philadelphia, PA June 2017.

Resnick S, Seamon MJ, Holena DH, Pascual JL, Reilly PM, Martin ND.: Early Declaration of Death by Neurologic Criteria Results in Greater Organ Donor Potential J Surg Res May (Epub) 2017.

Pascual JL, Cannon J. : Hemorrhagic Shock: Recognition, Pathophysiology and Management. Nova Science Publishers, Inc., New York, NY. May 2017.

J, Gray J, Miano T, Redline G, Teufel H, Collins T, Pascual-Lopez J, Sylvia M, Martin ND: Pain, Agitation, and Delirium Guidelines: Interprofessional Perspectives to Translate the Evidence. Dimens Crit Care Nurs Page: 36(3):164-173. May/Jun 2017.

Nunn AM, Hatchimonji JS, Holena DN, Seamon MJ, Smith BP, Kaplan LJ, Martin ND, Reilly PM, Schwab CW, Pascual JL: Boarding ICU patients: Are our rounding practices subpar? Am J Surg May 2017.

Nagata K, Browne KD, Suto Y, Kumasaka K, Cognetti J, Johnson VE, Marks J, Smith DH, Pascual JL.: Early Heparin Administration After TBI: Prolonged Cognitive Recovery Associated With Reduced Cerebral Edema and Neutrophil Sequestration. J Trauma Acute Care Surg. 2017 May 22. doi: 10.1097/TA.0000000000001590. J Trauma Acute Care Surg. May 2017.

Kuo LE, Kaufman E, Hoffman RL, Pascual JL, Martin ND, Kelz RR, Holena DN.: Failure-to-rescue after injury is associated with preventability: The results of mortality panel review of failure-to-rescue cases in trauma. PMID: 27788924 Surgery. 2017 Mar;161(3):782-790. doi: 10.1016/j.surg.2016.08.017. Epub 2016 Oct 25. Mar 2017.

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Last updated: 03/16/2018
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