Jose L. Pascual L.

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Associate Professor of Surgery at the Hospital of the University of Pennsylvania and the Presbyterian Medical Center of Philadelphia
Attending Surgeon, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending Intensivist, Penn e-lert eICU, Philadelphia, PA
Attending Surgeon, Penn Presbyterian Medical Center, Philadelphia, PA
Attending Surgical Intensivist, Pennsylvania Hospital, Philadelphia, PA
Clinical Associate , University of Pennsylvania School of Nursing
Patient Safety Officer , Department of Surgery, University of Penn Hospital
Attending Intensivist, Philadelphia Veteran’s Affairs Medical Center, Phila. PA, University of Pennsylvania
Co-medical Director , Surgical ICU, Hospital of the University of Pennsylvania
Reviewer , Penn Acute Research Collaborative (PARC) reviewer
Department: Surgery

Contact information
Division of Trauma & Surgical Critical Care
Perelman School of Medicine at the University of Pennsylvania
51 North 39th St,MOB 1st floor, Suite 120, Room 108
Philadelphia, PA 19104
Office: 215-662-7323
Fax: 215-243-4679
N/A (Physiology)
McGill University, Montreal, Quebec , 1990.
N/A (Biochemistry)
University of Ottawa, Ottawa, Ontario , 1992.
University of Ottawa, Ottawa, Ontario, 1996.
McGill University, Montreal, Quebac, 2005.
McGill University, Montreal, Quebec, 2005.
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Description of Research Expertise

Jose Pascual is a clinical surgeon specialized in trauma and critical care who has a special interest in shock and head injury. His research interests are shared in basic science research where he evaluates, in vivo, through intravital microscopy the real time microcirculation of pia on live rodent brains. He seeks to learn how a variety of insults including head injury and shock affect the microcirculation and how different management strategies influence these changes. This basic science work is translated into several clinical projects both retrospective and prospective evaluating the effects of different osmotherapeutic agents in traumatic brain injured patients as well as the immunemodulating effects of different resuscitation fluids in different forms of shock.

Description of Itmat Expertise

Traumatic brain injury
Osmotherapy for intracranial hypertension.
Hemorhhagic shock resuscitation
Immunemodulation in resuscitation
Hypertonic resuscitation
Neutropil endothelial interactions
Simulation in pedagogical methods for mediacal/surgical education

Selected Publications

Acker Andrew; Leonard Jennifer; Seamon Mark J; Holena Daniel N; Pascual Jose; Smith Brian P; Reilly Patrick M; Martin Niels D: Leaving contaminated trauma laparotomy wounds open reduces wound infections but does not add value Journal of surgical research 232: 450-455, July 2018.

Martin N, Pascual JL, Crowe D, Toevs C, Cereda MF, Mikkelsen M, Kaplan LJ.: Comfort at the crossroads: Service, therapy and emotional support animals in the intensive care unit and at the end-of-life. J Trauma Acute Care Surg. June 2018.

Nagata K, Suto Y, Cognetti J, Browne KD, Kumasaka K, Johnson VE, Kaplan L, Marks J, Smith DH, Pascual JL.: Early low-anticoagulant desulfated heparin after traumatic brain injury: Reduced brain edema and leukocyte mobilization is associated with improved watermaze learning ability weeks after injury. J Trauma Acute Care Surg May 2018.

Nunn AM, Hatchimonji JS, Holena DN, Seamon MJ, Smith BP, Kaplan LJ, Martin ND, Reilly PM, Schwab CW, Pascual JL. : Boardng ICU patients: Are you rounding practices subpar? American Journal of Surgery 215: 669-674, April 2018.

Suto Y, Nagata K, Ahmed SM, Jacovides C, Browne KD, Cognetti J, Weber MT, Johnson VE, Leone R, Kaplan LJ, Smith DH, Pascual JL.: A CONCOMITANT BONE FRACTURE DELAYS COGNITIVE RECOVERY FROM TRAUMATIC BRAIN INJURY. J Trauma Acute Care Surg April 2018.

Moore S, Weiss B, Pascual JL, Kaplan LJ.: Management of Acute Respiratory Failure in the Patient with Sepsis or Septic Shock. Surg Infect (Larchmt). Feb/Mar 2018.

Montmany S, Pascual JL, Kim PK, McMaster J, Pallisera A, Rebasa P, Luna A, Navarro S. : American vs. European Trauma Centers: A Comparison of Preventable Deaths.[Comparacion de la mortalidad evitable de un trauma center Americano vs. un centro de referencia europeo] Cirugia Espanola 95, Oct 2017.

Nagata K, Suto Y, Cognetti J, Browne KD, Kumasaka K, Johnson V, Kaplan L, Marks JA, Smith DH, Pascual JL.: Non-Anticoagulant desulfated heparin acutely reduces leukocyte mobilization and brain edema and improves watermaze learning ability weeks after traumatic brain injury. Podium presentation at the 76th Annual Meeting of the American Association for the Surgery of Trauma, Baltimore, MD. Sept 2017.

Sherma A, Sinha S, Oselkin M, Pascual J, Schuster J,: External carotid pseudoaneurysm due to wound vacuum placement after self-inflicted shotgun blast to face. Podium at 3rd Annual Critical Care Spectacular Case Presentation Competition, Philadelphia Drinker Society,Philadelphia, PA June 2017.

Resnick S, Seamon MJ, Holena DH, Pascual JL, Reilly PM, Martin ND.: Early Declaration of Death by Neurologic Criteria Results in Greater Organ Donor Potential J Surg Res May (Epub) 2017.

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Last updated: 08/20/2018
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