Amy C Durham

faculty photo
Associate Professor, Anatomic Pathology, University of Pennsylvania School of Veterinary Medicine
Assistant Dean for Education, University of Pennsylvania School of Veterinary Medicine

Contact information
3900 Delancey Street
Philadelphia, PA 19104
Office: 215 898 7871
Fax: 215 898 0719
BA (Psychology)
University of Virginia, 1997.
MS (Neuroscience)
Georgetown University, 2000.
VMD (Veterinary Medicine)
University of Pennsylvania, 2005.
Post-Graduate Training
Resident in Veterinary Anatomic Pathology, University of Pennsylvania, 2005-2008.
Permanent link
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Description of Itmat Expertise

Oncologic veterinary pathology
Spontaneous and experimental models of cancer

Description of Research Expertise

Oncologic pathology with a particular interest in lymphoma and employing the World Health Organization classification system for lymphoid neoplasms in domestic animals. One goal of the research is to identify certain subtypes of lymphomas and correlate these subtypes to clinical behavior and optimal treatment protocols. We also hope to gain more insight into these diseases in humans, using the dog as a spontaneous large animal model.

Selected Publications

Musciano Ayla R, Lanza Matthew R, Dubielzig Richard R, Teixeira Leandro B C, Durham Amy C: Clinical and histopathological classification of feline intraocular lymphoma. Veterinary ophthalmology Jul 2019.

Pierce John T, Cho Steve S, Nag Shayoni, Zeh Ryan, Jeon Jun, Holt David, Durham Amy, Nasrallah MacLean P, Singhal Sunil, Lee John Y K: Folate Receptor Overexpression in Human and Canine Meningiomas-Immunohistochemistry and Case Report of Intraoperative Molecular Imaging. Neurosurgery 85(3): 359-368, Sep 2019.

Guttin Talia, Walsh Audra, Durham Amy C, Reetz Jennifer A, Brown Dorothy C, Rondeau Mark P: Ability of ultrasonography to predict the presence and location of histologic lesions in the small intestine of cats. Journal of veterinary internal medicine 33(3): 1278-1285, May 2019.

Puri Munish, Hoover Shelley B, Hewitt Stephen M, Wei Bih-Rong, Adissu Hibret Amare, Halsey Charles H C, Beck Jessica, Bradley Charles, Cramer Sarah D, Durham Amy C, Esplin D Glen, Frank Chad, Lyle L Tiffany, McGill Lawrence D, Sánchez Melissa D, Schaffer Paula A, Traslavina Ryan P, Buza Elizabeth, Yang Howard H, Lee Maxwell P, Dwyer Jennifer E, Simpson R Mark: Automated Computational Detection, Quantitation, and Mapping of Mitosis in Whole-Slide Images for Clinically Actionable Surgical Pathology Decision Support. Journal of pathology informatics 10: 4, 2019.

Sorenmo Karin U, Durham Amy C, Kristiansen Veronica, Pena Laura, Goldschmidt Michael H, Stefanovski Darko: Developing and testing prognostic bio-scoring systems for canine mammary gland carcinomas. Veterinary and comparative oncology May 2019.

Church Molly E, Turek Bradley J, Durham Amy C: Neuropathology of Spontaneous Hypertensive Encephalopathy in Cats. Veterinary pathology 56(5): 778-782, 09 2019.

Predina Jarrod D, Runge Jeffrey, Newton Andrew, Mison Michael, Xia Leilei, Corbett Christopher, Shin Michael, Sulyok Lydia Frenzel, Durham Amy, Nie Shuming, Singhal Sunil, Holt David: Evaluation of Aminolevulinic Acid-Derived Tumor Fluorescence Yields Disparate Results in Murine and Spontaneous Large Animal Models of Lung Cancer. Scientific reports 9(1): 7629, May 2019.

Tarrant James C, Holt David E, Durham Amy C: Co-occurrence of Nasal Polyps and Neoplasms of the Canine Nasal Cavity. Veterinary pathology Page: 300985819854438, Jun 2019.

Church Molly E, Veluvolu Sridhar M, Durham Amy C, Woolard Kevin D: Clinical outcomes, ultrastructure and immunohistochemical features of canine high-grade olfactory neuroblastoma. Veterinary and comparative oncology Jun 2019.

Tidd Kathleen S, Durham Amy C, Brown Dorothy C, Velovolu Sridhar, Nagel Jonathan, Krick Erika L: Outcomes in 40 cats with discrete intermediate- or large-cell gastrointestinal lymphoma masses treated with surgical mass resection (2005-2015). Veterinary surgery : VS Jul 2019.

Wei Bih-Rong, Halsey Charles H, Hoover Shelley B, Puri Munish, Yang Howard H, Gallas Brandon D, Lee Maxwell P, Chen Weijie, Durham Amy C, Dwyer Jennifer E, Sánchez Melissa D, Traslavina Ryan P, Frank Chad, Bradley Charles, McGill Lawrence D, Esplin D Glen, Schaffer Paula A, Cramer Sarah D, Lyle L Tiffany, Beck Jessica, Buza Elizabeth, Gong Qi, Hewitt Stephen M, Simpson R Mark: Agreement in Histological Assessment of Mitotic Activity Between Microscopy and Digital Whole Slide Images Informs Conversion for Clinical Diagnosis. Academic pathology 6: 2374289519859841, Jan-Dec 2019.

Aghazadeh Mahdis, Shi Mang, Pesavento Patricia A, Durham Amy C, Polley Tamsen, Donahoe Shannon L, Troyer Ryan M, Barrs Vanessa R, Holmes Edward C, Beatty Julia A: Transcriptome Analysis and In Situ Hybridization for FcaGHV1 in Feline Lymphoma. Viruses 10(9), 08 2018.

Lanza Matthew R, Musciano Ayla R, Dubielzig Richard D, Durham Amy C: Clinical and pathological classification of canine intraocular lymphoma. Veterinary ophthalmology 21(2): 167-173, Mar 2018.

Patton John B, Bonne-Année Sandra, Deckman Jessica, Hess Jessica A, Torigian April, Nolan Thomas J, Wang Zhu, Kliewer Steven A, Durham Amy C, Lee James J, Eberhard Mark L, Mangelsdorf David J, Lok James B, Abraham David: Methylprednisolone acetate induces, and Δ7-dafachronic acid suppresses, hyperinfection in NSG mice. Proceedings of the National Academy of Sciences of the United States of America 115(1): 204-209, 01 2018.

Raposo-Ferreira Talita M M, Brisson Becky K, Durham Amy C, Laufer-Amorim Renee, Kristiansen Veronica, Puré Ellen, Volk Susan W, Sorenmo Karin: Characteristics of the Epithelial-Mesenchymal Transition in Primary and Paired Metastatic Canine Mammary Carcinomas. Veterinary pathology 55(5): 622-633, 09 2018.

Wang Guannan, Wu Ming, Maloneyhuss Martha A, Wojcik John, Durham Amy C, Mason Nicola J, Roth David B: Actionable mutations in canine hemangiosarcoma. PloS one 12(11): e0188667, 2017.

Cicchini Michelle, Buza Elizabeth L, Sagal Kyra M, Gudiel A Andrea, Durham Amy C, Feldser David M: Context-Dependent Effects of Amplified MAPK Signaling during Lung Adenocarcinoma Initiation and Progression. Cell reports 18(8): 1958-1969, 02 2017.

Keating Jane J, Runge Jeffrey J, Singhal Sunil, Nims Sarah, Venegas Ollin, Durham Amy C, Swain Gary, Nie Shuming, Low Philip S, Holt David E: Intraoperative near-infrared fluorescence imaging targeting folate receptors identifies lung cancer in a large-animal model. Cancer 123(6): 1051-1060, 05 2017.

Case Ashley, Brisson Becky K, Durham Amy C, Rosen Suzanne, Monslow James, Buza Elizabeth, Salah Pascale, Gillem Julie, Ruthel Gordon, Veluvolu Sridhar, Kristiansen Veronica, Puré Ellen, Brown Dorothy C, Sørenmo Karin U, Volk Susan W: Identification of prognostic collagen signatures and potential therapeutic stromal targets in canine mammary gland carcinoma. PloS one 12(7): e0180448, 2017.

Krick Erika Lauren, Kiupel Matti, Durham Amy C, Thaiwong Tuddow, Brown Dorothy C, Sorenmo Karin U: Investigating Associations Between Proliferation Indices, C-kit, and Lymph Node Stage in Canine Mast Cell Tumors. Journal of the American Animal Hospital Association 53(5): 258-264, Sep/Oct 2017.

Zhao Liang, Thorsheim Chelsea L, Suzuki Aae, Stalker Timothy J, Min Sang H, Lian Lurong, Fairn Gregory D, Cockcroft Shamshad, Durham Amy, Krishnaswamy Sriram, Abrams Charles S: Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis. Nature communications 8(1): 1216, 10 2017.

Katlinskaya Yuliya V, Katlinski Kanstantsin V, Lasri Audrey, Li Ning, Beiting Daniel P, Durham Amy C, Yang Ting, Pikarsky Eli, Lengner Christopher J, Johnson F Brad, Ben-Neriah Yinon, Fuchs Serge Y: Type I Interferons Control Proliferation and Function of the Intestinal Epithelium. Molecular and cellular biology 36(7): 1124-35, Jan 2016.

Lee Kyoung Eun, Spata Michelle, Bayne Lauren J, Buza Elizabeth L, Durham Amy C, Allman David, Vonderheide Robert H, Simon M Celeste: Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia. Cancer discovery 6(3): 256-69, Mar 2016.

Holt David, Parthasarathy Ashwin B, Okusanya Olugbenga, Keating Jane, Venegas Ollin, Deshpande Charuhas, Karakousis Giorgos, Madajewski Brian, Durham Amy, Nie Shuming, Yodh Arjun G, Singhal Sunil: Intraoperative near-infrared fluorescence imaging and spectroscopy identifies residual tumor cells in wounds. Journal of biomedical optics 20(7): 76002, Jul 2015.

Hague D W, Joslyn S, Bush W W, Glass E N, Durham A C: Clinical, magnetic resonance imaging, and histopathologic findings in 6 dogs with surgically resected extraparenchymal spinal cord hematomas. Journal of veterinary internal medicine 29(1): 225-30, Jan 2015.

Miller Craig A, Durham Amy C, Schaffer Paula A, Ehrhart E J, Powers Barb E, Duncan Colleen G: Classification and clinical features in 88 cases of equine cutaneous lymphoma. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 27(1): 86-91, Jan 2015.

Lo Albert, Wang Liang-Chuan S, Scholler John, Monslow James, Avery Diana, Newick Kheng, O'Brien Shaun, Evans Rebecca A, Bajor David J, Clendenin Cynthia, Durham Amy C, Buza Elizabeth L, Vonderheide Robert H, June Carl H, Albelda Steven M, Puré Ellen: Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells. Cancer research 75(14): 2800-2810, Jul 2015.

V.E. Watson, M.M. Hobday, A.C. Durham: Focal intestinal lipogranulomatous lymphangitis: 6 dogs (2008-2011). Journal of Veterinary Internal Medicine 28(1): 48-51, Jan-Feb 2014.

Shay Jessica E S, Imtiyaz Hongxia Z, Sivanand Sharanya, Durham Amy C, Skuli Nicolas, Hsu Sarah, Mucaj Vera, Eisinger-Mathason T S Karin, Krock Bryan L, Giannoukos Dionysios N, Simon M Celeste: Inhibition of hypoxia-inducible factors limits tumor progression in a mouse model of colorectal cancer. Carcinogenesis 35(5): 1067-77, May 2014.

Neary Casey P, Bush William W, Tiches Deena M, Durham Amy C, Gavin Patrick R: Synovial myxoma in the vertebral column of a dog: MRI description and surgical removal. Journal of the American Animal Hospital Association 50(3): 198-202, May-Jun 2014.

Durham A C, Mariano A D, Holmes E S, Aronson L: Characterization of post transplantation lymphoma in feline renal transplant recipients. Journal of comparative pathology 150(2-3): 162-8, Feb-Apr 2014.

Wang Liang-Chuan S, Lo Albert, Scholler John, Sun Jing, Majumdar Rajrupa S, Kapoor Veena, Antzis Michael, Cotner Cody E, Johnson Laura A, Durham Amy C, Solomides Charalambos C, June Carl H, Puré Ellen, Albelda Steven M: Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity. Cancer immunology research 2(2): 154-66, Feb 2014.

K. E. Flood-Knapik, A. C. Durham,T. P. Gregor, M. D. Sánchez, M. E. Durney, K. U. Sorenmo: Clinical, histopathological and immunohistochemical characterization of canine indolent lymphoma. Veterinary and Comparative Oncology 11(4): 272-286, 2013.

A. C. Durham, C. A. Pillitteri, M. San Myint, V. E. Valli: 203 cases of equine lymphoma classified according to the world health organization (WHO) classification criteria. Veterinary Pathology 50(1): 86-93, 2013.

Amanda L. Maas, Shirron L. Carter, E. Paul Wileyto, Joann Miller, Min Yuan, Guoqiang Yu, Amy C. Durham, Theresa M. Busch.: Tumor Vascular Microenvironment Determines Responsiveness to Photodynamic Therapy. Cancer Research 72(8): 1-10, 2012.

Avila JL, Troutman S, Durham A, Kissil JL: Notch1 is not required for acinar-to-ductal metaplasia in a model of Kras-induced pancreatic ductal adenocarcinoma. PLoS One 7(12): e52133, 2012.

Arielle Glatman Zaretsky, Jonathan S. Silver, Marie Siwicki, Amy Durham, Carl F. Ware, Christopher A. Hunter: Infection with Toxoplasma gondii alters lymphotoxin expression associated with changes in splenic architecture and humoral responses. Infection and Immunity 80(10): 3602-10, Oct 2012.

Elizabeth L. Buza, Robert A. Menzies, Michael H. Goldschmidt, Amy C. Durham: Malignant peripheral nerve sheath tumor in a cat with nodal and pulmonary metastases. Journal of Veterinary Diagnostic Investigation 2012.

V.E. Valli, M. San Myint, A. Barthel, D. Bienzle, J. Caswell,F. Colbatzky, A. Durham, E.Ehrhart, Y. Johnson, C. Jones, M.Kiupel, P. LaBelle, S. Lester, M. Miller, P. Moore, S.Moroff, P. Roccabianca, J. Ramos-Vara, A. Ross, T. Scase, H.,Tvedten, W. Vernau: World Health Organization Classification of Canine Malignant Lymphomas: Report of the Lymphoma Committee of the American College of Veterinary Pathologists Oncology Initiative. Veterinary Pathology Vol 48 : 198-211, 2011.

Grossman CE, Pickup S, Durham A, Wileyto EP, Putt ME, Busch TM: Photodynamic therapy of disseminated non-small cell lung carcinoma in a murine model. Lasers Surg Med 43(7): 663-75, 2011.

Eugenia Pacheco-Pinedo, Amy Durham, Kathleen Stewart, Ashley Goss, Min Min Lu, Francesco DeMayo, Edward Morrisey: Wnt/beta-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium. Journal of Clinical Investigation 121(5): 1935-1945, 2011.

Smita S Matkar, Amy Durham, Angela Brice, Timothy C Wang, Anil K. Rustgi, Xianxin Hua. : Systemic activation of K-ras rapidly induces gastric hyperplasia and metaplasia in mice. American Journal of Cancer Research 1(4): 432-445, 2011.

AC Haley, SR Platt, M Kent, SJ Schatzberg, A Durham, S Cochrane, D Westworth, GD Shelton: Breed specific polymyositis in the Hungarian vizsla dog. Journal of Veterinary Internal Medicine 25(2), 2011.

Jantra Ngosuwan Suran, Amy Durham, Wilfried Mai, Gabriela Seiler: Contrast enhancement of extradural compressive material on magnetic resonance imaging. Veterinary Radiology & Ultrasound 52(1): 10-16, 2011.

Eshar D., Wyre NR., Griessamayr P., Durham A., Hoots E: Diagnosis and treatment of myelo-osteolytic lymphoma of the femur by mid-to-hemipelvectomy and chemotherapy in a domestic ferret (Mustela furo). Journal of the American Veterinary Association 237(13), 2010.

Margaret Fordham, Karen Rosenthal, Amy Durham, Lili Duda , András M. Komáromy: Intraocular osteosarcoma in an Umbrella Cockatoo (Cacatua alba). Veterinary Ophthalmology 13(1): 103-108, 2010.

Jolly Mazumdarl, Michele M. Hickey, Dhruv K. Pant, Amy Durham, Alejandro Sweet-Cordero, Anil Vachani, Tyler Jacks, Lewis A. Chodosh, Joseph L. Kissil, M. Celeste Simon, Brian Keith: HIF-2a deletion promotes Kras-driven lung tumor development. Proceedings of the National Academy of Sciences Vol. 107 ((32)): 14182-14187, 2010.

O Gilad, B Nabet, R Ragland, D Schoppy, K Smith, A Durham, E Brown. : Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing dosage-dependent synthetic lethality or elevated tumorigenesis. Cancer Research 70: 9693-9702, 2010.

Hongxia Z. Imtiyaz, Emily P. Williams, Michele M. Hickey, Shetal A. Patel, Amy C. Durham, Li-Jun, Yuan, Brian Keith, and M. Celeste Simon. : Hypoxia-inducible factor-2alpha regulates macrophage function in mouse models of acute and tumor inflammation. J Clin Invest 120(8): 2699-2714, 2010.

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Last updated: 06/30/2021
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