Tejvir S. Khurana

faculty photo
Professor of Physiology
Member, Pennsylvania Muscle Institute
Department: Physiology

Contact information
Department of Physiology,
University of Pennsylvania,
750 Clinical Research Building (CRB),
415 Curie Boulevard,
Philadelphia, PA 19004-6085
Office: (215) 898-4116
Fax: (215) 573-2273
Lab: (215) 573-2640
Graduate Group Affiliations
Education:
MBBS (Medicine)
Delhi University, 1985.
Ph.D. (Neurobiology)
Harvard University, 1992.
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Description of Research Expertise

muscle, muscular disease, muscular dystrophy, therapeutics, gene therapy, extraocular muscle, transcriptome, proteome, genomics, sports medicine, athletic doping, hypoxia, altitude, respiratory, neuromuscular junctions, synapses.

Description of Itmat Expertise

Dr. Khurana is developing novel therapeutic strategies for muscular dystrophies, utrophin upregulation, myostatin-blockade and stem cell-based strategies.

Selected Publications

Loro E, Bisetto S, Khurana TS: Mitochondrial ultrastructural adaptations in fast muscles of mice lacking IL15RA. J Cell Sci 131, 2018.

Song S, Wen Y, Tong H, Loro E, Gong Y, Liu J, Hong S, Li L, Khurana TS, Chu M, Sun Z: The HDAC3 Enzymatic Activity Regulates Skeletal Muscle Fuel Metabolism. J Mol Cell Biol 2018.

Simonson B, Subramanya V, Chan MC, Zhang A, Franchino H, Ottaviano F, Mishra MK, Knight AC, Hunt D, Ghiran I, Khurana TS, Kontaridis MI, Rosenzweig A, Das S: DDiT4L promotes autophagy and inhibits pathological cardiac hypertrophy in response to stress. Sci Signal 10 (468): eaaf5967, 2017.

Loro E, Ramaswamy G, Chandra A, Tseng WJ, Mishra MK, Shore EM, Khurana TS: IL15RA is required for osteoblast function and bone mineralization. Bone 103: 20-30, 2017.

Mishra MK, Loro E, Sengupta K, Wilton SD, Khurana TS: Functional improvement of dystrophic muscle by repression of utrophin: let-7c interaction. PLoS One 12(10): e0182676, 2017.

Loro E, Wang SH, Schwab RJ, Khurana TS: In Vivo Evaluation of the Mechanical and Viscoelastic Properties of the Rat Tongue. J Vis Exp 6: (125), 2017.

Hong S, Zhou W, Fang B, Lu W, Loro E, Damle M, Ding G, Jager J, Zhang S, Zhang Y, Feng D, Chu Q, Dill BD, Molina H, Khurana TS, Rabinowitz JD, Lazar MA, Sun Z: Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion. Nat Med 23: 223-234, 2017.

Arsenault PR, Song D, Chung YJ, Khurana TS, Lee FS: The Zinc Finger of Prolyl Hydroxylase Domain Protein 2 Is Essential for Efficient Hydroxylation of Hypoxia-Inducible Factor α Mol Cell Biol 36(18): 2328-43, 2016.

Frederick DW, Loro E, Liu L, Davila A Jr, Chellappa K, Silverman IM, Quinn WJ 3rd, Gosai SJ, Tichy ED, Davis JG, Mourkioti F, Gregory BD, Dellinger RW, Redpath P, Migaud ME, Nakamaru-Ogiso E, Rabinowitz JD, Khurana TS, Baur JA: Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle. Cell Metab 24(2): 269-82, 2016.

Bird SB, Krajacic P, Sawamoto K, Bunya N, Loro E, Khurana TS.: Pharmacotherapy to protect the neuromuscular junction after acute organophosphorus pesticide poisoning. Ann N Y Acad Sci 1374(1): 86-93, 2016.

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Last updated: 11/27/2018
The Trustees of the University of Pennsylvania