Richard Aplenc

faculty photo
Professor of Pediatrics at the Children's Hospital of Philadelphia
Section Chief, Hematologic Malignancies, The Children's Hospital of Philadelphia
Associate Physician, The Children's Hospital of Philadelphia
Department: Pediatrics

Contact information
CTRB Room 4018
3501 Civic Center Blvd
Philadelphia, PA 19104
Office: 2674267252
Education:
A.B. (Classics)
Princeton University, 1988.

University of Pennsylvania, Post-Baccalaureate Pre-Health Program, 1989.
MD
University of Virginia, 1994.
MSCE (Clinical Epidemiology and Biostatistics)
University of Pennsylvania, 2002.
PhD (Epidemiology)
University of Pennsylvania, 2011.
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Description of Itmat Expertise

Dr. Aplenc's research involves molecular epidemiology, pediatric cancer Phase I clinical trials, treatment of pediatric AML, and the use of genetic polymorphism data to predict treatment response to therapeutic interventions, particularly in pediatric cancer therapy.

Selected Publications

Vujkovic Marijana, Bellamy Scarlett L, Zuppa Athena F, Gastonguay Marc, Moorthy Ganesh S, Ratshaa Bakgaki R, Han Xiaoyan, Steenhoff Andrew P, Mosepele Mosepele, Strom Brian L, Aplenc Richard, Bisson Gregory P, Gross Robert: Brief Report: CYP2B6 516G>T Minor Allele Protective of Late Virologic Failure in Efavirenz-Treated HIV-Infected Patients in Botswana. Journal of acquired immune deficiency syndromes (1999) 75(4): 488-491, Aug 2017.

Gross Robert, Bellamy Scarlett L, Ratshaa Bakgaki, Han Xiaoyan, Vujkovic Marijana, Aplenc Richard, Steenhoff Andrew P, Mosepele Mosepele, Moorthy Ganesh, Zuppa Athena F, Strom Brian L, Bisson Gregory P: CYP2B6 genotypes and early efavirenz-based hiv treatment outcomes in botswana. AIDS (London, England) Jul 2017.

Tarlock Katherine, Alonzo Todd A, Loken Michael R, Gerbing Robert B, Ries Rhonda E, Aplenc Richard, Sung Lillian, Raimondi Susana C, Hirsch Betsy A, Kahwash Samir B, McKenney Amy, Kolb E Anders, Gamis Alan S, Meshinchi Soheil: Disease Characteristics and Prognostic Implications of Cell-Surface FLT3 Receptor (CD135) Expression in Pediatric Acute Myeloid Leukemia: A Report from the Children's Oncology Group. Clinical cancer research : an official journal of the American Association for Cancer Research 23(14): 3649-3656, Jul 2017.

Guest Erin M, Aplenc Richard, Sung Lillian, Raimondi Susana C, Hirsch Betsy A, Alonzo Todd A, Gerbing Robert B, Wang Yi-Cheng Jim, Kahwash Samir B, Heerema-McKenney Amy, Meshinchi Soheil, Gamis Alan S: Gemtuzumab ozogamicin in infants with AML: results from the Children's Oncology Group trials, AAML03P1 and AAML0531. Blood Jul 2017.

Lamba Jatinder K, Chauhan Lata, Shin Miyoung, Loken Michael R, Pollard Jessica A, Wang Yi-Cheng, Ries Rhonda E, Aplenc Richard, Hirsch Betsy A, Raimondi Susana C, Walter Roland B, Bernstein Irwin D, Gamis Alan S, Alonzo Todd A, Meshinchi Soheil: CD33 Splicing Polymorphism Determines Gemtuzumab Ozogamicin Response in De Novo Acute Myeloid Leukemia: Report From Randomized Phase III Children's Oncology Group Trial AAML0531. Journal of clinical oncology : official journal of the American Society of Clinical Oncology Page: JCO2016712513, Jun 2017.

Vujkovic Marijana, Attiyeh Edward F, Ries Rhonda E, Goodman Elizabeth K, Ding Yang, Kavcic Marko, Alonzo Todd A, Wang Yi-Cheng, Gerbing Robert B, Sung Lillian, Hirsch Betsy, Raimondi Susana, Gamis Alan S, Meshinchi Soheil, Aplenc Richard: Genomic architecture and treatment outcome in pediatric acute myeloid leukemia: a Children's Oncology Group report. Blood 129(23): 3051-3058, Jun 2017.

Miller Tamara P, Li Yimei, Kavcic Marko, Getz Kelly D, Huang Yuan-Shun V, Sung Lillian, Alonzo Todd A, Gerbing Robert, Daves Marla H, Horton Terzah M, Pulsipher Michael A, Pollard Jessica, Bagatell Rochelle, Seif Alix E, Fisher Brian T, Luger Selina, Gamis Alan S, Adamson Peter C, Aplenc Richard: Center-level variation in accuracy of adverse event reporting in a clinical trial for pediatric acute myeloid leukemia: A report from the Children's Oncology Group. Haematologica Jun 2017.

Johnston Donna L, Alonzo Todd A, Gerbing Robert B, Aplenc Richard, Woods William G, Meshinchi Soheil, Gamis Alan S: Central nervous system disease in pediatric acute myeloid leukemia: A report from the Children's Oncology Group. Pediatric blood & cancer Apr 2017.

Miller Tamara P, Li Yimei, Getz Kelly D, Dudley Jesse, Burrows Evanette, Pennington Jeffrey, Ibrahimova Azada, Fisher Brian T, Bagatell Rochelle, Seif Alix E, Grundmeier Robert, Aplenc Richard: Using electronic medical record data to report laboratory adverse events. British journal of haematology 177(2): 283-286, Apr 2017.

Hanley Michael J, Mould Diane R, Taylor Timothy J, Gupta Neeraj, Suryanarayan Kaveri, Neuwirth Rachel, Esseltine Dixie-Lee, Horton Terzah M, Aplenc Richard, Alonzo Todd A, Lu Xiaomin, Milton Ashley, Venkatakrishnan Karthik: Population Pharmacokinetic Analysis of Bortezomib in Pediatric Leukemia Patients: Model-Based Support for Body Surface Area-Based Dosing Over the 2- to 16-Year Age Range. Journal of clinical pharmacology Apr 2017.

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Last updated: 07/17/2017
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