Richard Aplenc

faculty photo
Associate Professor of Pediatrics at the Children's Hospital of Philadelphia
Associate Physician, The Children's Hospital of Philadelphia
Department: Pediatrics

Contact information
CTRB Room 4018
3501 Civic Center Blvd
Philadelphia, PA 19104
Office: 2674267252
A.B. (Classics)
Princeton University, 1988.

University of Pennsylvania, Post-Baccalaureate Pre-Health Program, 1989.
University of Virginia, 1994.
MSCE (Clinical Epidemiology and Biostatistics)
University of Pennsylvania, 2002.
PhD (Epidemiology)
University of Pennsylvania, 2011.
Permanent link

Description of Itmat Expertise

Dr. Aplenc's research involves molecular epidemiology, pediatric cancer Phase I clinical trials, treatment of pediatric AML, and the use of genetic polymorphism data to predict treatment response to therapeutic interventions, particularly in pediatric cancer therapy.

Selected Publications

Getz K. D., Li Y., Alonzo T. A., Hall M., Gerbing R. B., Sung L., Huang Y. S., Arnold S., Seif A. E., Miller T. P., Bagatell R., Fisher B. T., Adamson P. C., Gamis A., Keren R., Aplenc R.: Comparison of in-patient costs for children treated on the AAML0531 clinical trial: a report from the Children’s Oncology Group. Pediatr Blood Cancer May 2015.

Miller T. P., Troxel A. B., Li Y., Huang Y. S., Alonzo T. A., Gerbing R. B., Hall M., Torp K., Fisher B. T., Bagatell R., Seif A. E., Sung L., Gamis A., Rubin D., Luger S., Aplenc R. : Comparison of administrative/billing data to expected protocol-mandated chemotherapy exposure in children with acute myeloid leukemia: a report from the Children's Oncology Group. Pediatr Blood Cancer Mar 2015.

Salazar E., Bernhardt M. B., Li Y., Aplenc R., Adamson P. C.: The impact of chemotherapy shortages on COG and local clinical trials: a report from the Children's Oncology Group. Pediatr Blood Cancer Feb 2015.

Cantu E., Shah R. J., Lin W., Daye Z. J., Diamond J. M., Suzuki Y., Ellis J. H., Borders C. F., Andah G. A., Beduhn B., Meyer N. J., Ruschefski M., Aplenc R., Feng R., Christie J. D.; Lung Transplant Outcomes Group Investigators. : Oxidant stress regulatory genetic variation in recipients and donors contributes to risk of primary graft dysfunction after lung transplantation. J Thorac Cardiovasc Surg 149(2): 596-602, Feb 2015.

Wray L., Vujkovic M., McWilliams T., Cannon S., Devidas M., Stork L., Aplenc R.: TPMT and MTHFR genotype is not associated with altered risk of thioguanine-related sinusoidal obstruction syndrome in pediatric acute lymphoblastic leukemia: a report from the Children's Oncology Group. Pediatr Blood Cancer 61(11): 2086-8, Nov 2014.

Freedman J. L., Faerber J., Kang T. I., Dai D., Fisher B. T., Huang Y. S., Li Y., Aplenc R., Feudtner C.: Predictors of antiemetic alteration in pediatric acute myeloid leukemia. Pediatr Blood Cancer 61(10): 1798-805, Oct 2014.

Maude S. L., Frey N., Shaw P. A., Aplenc R., Barrett D. M., Bunin N. J., Chew A., Gonzalez V. E., Zheng Z., Lacey S. F., Mahnke Y. D., Melenhorst J. J., Rheingold S. R., Shen A., Teachey D. T., Levine B. L., June C. H., Porter D. L., Grupp S. A.: Chimeric antigen receptor T cells for sustained remissions in leukemia. New Engl J Med 371(16): 1507-17, Oct 2014.

Goodman E. K., Reilly A. F., Fisher B. T., Fitzgerald J., Li Y., Seif A. E., Huang Y. S., Bagatell R., Aplenc R.: Association of weekend admission with hospital length of stay, time to chemotherapy, and risk for respiratory failure in pediatric patients with newly diagnosed leukemia at freestanding U.S. children's hospitals. JAMA Pediatr Aug 2014.

Gamis A. S., Alonzo T. A., Meshinchi S., Sung L., Gerbing R. B., Raimondi S. C., Hirsch B. A., Kahwash S. B., Heerema-McKenney A., Winter L., Glick K., Davies S. M., Byron P., Smith F. O., Aplenc R.: Gemtuzumab ozogamicin in children and adolescents with de novo acute myeloid leukemia improves event-free survival by reducing relapse risk: results from the randomized phase III Children's Oncology Group trial AAML0531. J Clin Oncol Aug 2014.

Desai A. V., Kavcic M., Huang Y. S., Herbst N., Fisher B. T., Seif A. E., Li Y., Hennessy S., Aplenc R., Bagatell R.: Establishing a high-risk neuroblastoma cohort using the Pediatric Health Information System database. Pediatr Blood Cancer 61(6): 1129-31, Jun 2014.

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Last updated: 05/11/2015
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