Richard Aplenc

faculty photo
Associate Professor of Pediatrics at the Children's Hospital of Philadelphia
Associate Physician, The Children's Hospital of Philadelphia
Department: Pediatrics

Contact information
CTRB Room 4018
3501 Civic Center Blvd
Philadelphia, PA 19104
Office: 2674267252
A.B. (Classics)
Princeton University, 1988.

University of Pennsylvania, Post-Baccalaureate Pre-Health Program, 1989.
University of Virginia, 1994.
MSCE (Clinical Epidemiology and Biostatistics)
University of Pennsylvania, 2002.
PhD (Epidemiology)
University of Pennsylvania, 2011.
Permanent link

Description of Itmat Expertise

Dr. Aplenc's research involves molecular epidemiology, pediatric cancer Phase I clinical trials, treatment of pediatric AML, and the use of genetic polymorphism data to predict treatment response to therapeutic interventions, particularly in pediatric cancer therapy.

Selected Publications

Wray L., Vujkovic M., McWilliams T., Cannon S., Devidas M., Stork L., Aplenc R.: TPMT and MTHFR genotype is not associated with altered risk of thioguanine-related sinusoidal obstruction syndrome in pediatric acute lymphoblastic leukemia: a report from the Children's Oncology Group. Pediatr Blood Cancer 61(11): 2086-8, Nov 2014.

Freedman J. L., Faerber J., Kang T. I., Dai D., Fisher B. T., Huang Y. S., Li Y., Aplenc R., Feudtner C.: Predictors of antiemetic alteration in pediatric acute myeloid leukemia. Pediatr Blood Cancer 61(10): 1798-805, Oct 2014.

Maude S. L., Frey N., Shaw P. A., Aplenc R., Barrett D. M., Bunin N. J., Chew A., Gonzalez V. E., Zheng Z., Lacey S. F., Mahnke Y. D., Melenhorst J. J., Rheingold S. R., Shen A., Teachey D. T., Levine B. L., June C. H., Porter D. L., Grupp S. A.: Chimeric antigen receptor T cells for sustained remissions in leukemia. New Engl J Med 371(16): 1507-17, Oct 2014.

Goodman E. K., Reilly A. F., Fisher B. T., Fitzgerald J., Li Y., Seif A. E., Huang Y. S., Bagatell R., Aplenc R.: Association of weekend admission with hospital length of stay, time to chemotherapy, and risk for respiratory failure in pediatric patients with newly diagnosed leukemia at freestanding U.S. children's hospitals. JAMA Pediatr Aug 2014.

Gamis A. S., Alonzo T. A., Meshinchi S., Sung L., Gerbing R. B., Raimondi S. C., Hirsch B. A., Kahwash S. B., Heerema-McKenney A., Winter L., Glick K., Davies S. M., Byron P., Smith F. O., Aplenc R.: Gemtuzumab ozogamicin in children and adolescents with de novo acute myeloid leukemia improves event-free survival by reducing relapse risk: results from the randomized phase III Children's Oncology Group trial AAML0531. J Clin Oncol Aug 2014.

Desai A. V., Kavcic M., Huang Y. S., Herbst N., Fisher B. T., Seif A. E., Li Y., Hennessy S., Aplenc R., Bagatell R.: Establishing a high-risk neuroblastoma cohort using the Pediatric Health Information System database. Pediatr Blood Cancer 61(6): 1129-31, Jun 2014.

Luskin M., Wertheim G., Morrissette J., Daber R., Biegel J., Wilmoth D., Kersun L., King R., Paessler M., Simon C., Aplenc R., Loren A.: CLL/SLL diagnosed in an adolescent. Pediatr Blood Cancer 61(6): 1107-10, Jun 2014.

Fraser C., Brown P., Megason G., Ahn H. S., Cho B., Kirov I., Frankel L., Aplenc R., Bensen-Kennedy D., Munteanu M., Weaver J., Harker-Murray P.: Open-label bendamustine monotherapy for pediatric patients with relapsed or refractory acute leukemia: efficacy and tolerability. J Pediatr Hematol Oncol 36(4): e212-8, May 2014.

Seif A. E., Fisher B. T., Li Y., Torp K., Rheam D. P., Huang Y. S., Harris T., Shah A., Hall M., Fieldston E. S., Kavcic M., Vujkovic M., Bailey L. C., Kersun L. S., Reilly A. F., Rheingold S. R., Walker D. M., Aplenc R.: Patient and hospital factors associated with induction mortality in acute lymphoblastic leukemia. Pediatr Blood Cancer 61(5): 846-52, May 2014.

Aplenc R., Zhang M. J., Sung L., Zhu X., Ho V., Cooke K., Dvorak C., Hale G., Isola L., Lazarus H., McCarthy P., Olsson R., Pulsipher M., Pasquini M., Bunin N; Regimen-Related Toxicity Working Committee, Center for International Blood and Marrow Transplant Research.: Effect of body mass in children with hematologic malignancies undergoing allogeneic bone marrow transplantation. Blood 123(22): 3504-11, May 2014.

back to top
Last updated: 12/02/2014
The Trustees of the University of Pennsylvania