Lubica Rauova

faculty photo
Research Associate Professor of Pediatrics
Department: Pediatrics

Contact information
The Childrens Hospital of Philadelphia
3615 Civic Center Blv
ARC Room 316F
Philadelphia, PA 1910
Office: 215-426-2883
Lab: 215-590-1971
MD (Medicine)
Masaryk University, Brno, Czech Republic, 1987.
PhD (Internal Medicine)
Commenius University, Bratislava, Slovakia, 1992.
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Description of Itmat Expertise

Thrombosis and hemostasis, role of monocytes and neutrophils in thrombosis, platelet factor 4 (PF4), autoimmunity, heparin induced thrombocytopenia, antiphospholipid syndrom, systemic lupus erythematosus (SLE), microfluidic models, in vivo imaging - lung, liver, spleen;

Description of Research Expertise

I have extensive clinical training and research experience in the fields of autoimmunity and hematology, giving me an ideal background for unraveling molecular and cellular interactions involved in hemostasis and thrombosis. Most of my research for the past few years has been on the pathogenesis of heparin-induced thrombocytopenia (HIT), an immune mediated thrombotic disorder. Since 2003, I have been continuously funded through extramural grants in the field of HIT. My research on HIT has provided seminal insights into understanding the nature of the antigenic complexes formed by platelet factor 4 (PF4) and heparin, and my recent studies on the role of monocytes in HIT demonstrate the importance of monocyte-platelet interactions, altogether leading to a new concept for the thrombosis accompanying delayed HIT. I also have expertise in the use of mouse models of HIT, including both large and small vessel thrombosis, and in microfluidic models of HIT, studying platelet and leucocyte adhesion and fibrin formation under controlled shear stress conditions.

Selected Publications

Tutwiler V, Madeeva D, Ahn HS, Andrianova I, Hayes V, Zheng XL, Cines DB, McKenzie SE, Poncz M and Rauova L: Platelet transactivation by monocytes promotes the prothrombotic state in heparin-induced thrombocytopenia. Blood 127(4): 464, Feb 2016.

Cai Z, Yarovoi SV, Zhu Z, Rauova L, Hayes V, Lebedeva T, Liu Q, Poncz M, Arepally G, Cines DB, Greene MI: Atomic description of the immune complex involved in heparin-induced thrombocytopenia. Nature Communications 6(8277): 9277, Sep 2015.

Cuker A, Rauova L, Bolgiano D, Matthai WH Jr, Poncz M, Konkle BA.: Atherosclerosis is not a risk factor for anti-platelet factor 4/heparin antibody formation after cardiopulmonary bypass surgery. Thromb Haemost 111(6): 1191-3, Jun 2014.

Litvinov RI, Yarovoi SV, Rauova L, Barsegov V, Sachais BS, Rux AH, Hinds JL, Arepally GM, Cines DB, Weisel JW.: Distinct specificity and single-molecule kinetics characterize the interaction of pathogenic and non-pathogenic antibodies against platelet factor 4-heparin complexes with platelet factor 4. J Biol Chem 288(46): 33060-70, Nov 2013.

Zhi H, Rauova L, Hayes V, Gao C, Boylan B, Newman DK, McKenzie SE, Cooley BC, Poncz M, Newman PJ: Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo. Blood 121(10): 1858-67, Mar 2013.

Sachais BS, Litvinov RI, Yarovoi SV, Rauova L, Hinds JL, Rux AH, Arepally GM, Poncz M, Cuker A, Weisel JW, Cines DB: Dynamic antibody-binding properties in the pathogenesis of HIT. Blood 120(5): 1137-42, Aug 2012.

Rauova Lubica: "Radical" model of thrombosis. Blood 119(8): 1798-9, Feb 2012.

Finley MJ, Rauova L, Alferiev IS, Weisel JW, Levy RJ, Stachelek SJ: Diminished adhesion and activation of platelets and neutrophils with CD47 functionalized blood contacting surfaces. Biomaterials 33(24): 5803-11, Aug 2012.

Rauova L, Hirsch JD, Greene TK, Zhai L, Hayes VM, Kowalska MA, Cines DB, Poncz M: Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia. Blood 116(23): 5021-31, Dec 2010.

Fuentes R, Wang Y, Hirsch J, Wang Ch, Rauova L, Worthen GS, Kowalska MA, Poncz M: Infusion of mature megakaryocytes into mice yields functional platelets. The Journal of clinical investigation 120(11): 3917-22, Nov 2010.

Rauova L, Zhai L, Kowalska MA, Arepally GM, Cines DB, Poncz M: Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications. Blood 107(6): 2346-53, Mar 2006.

Rauova L, Poncz M, McKenzie SE, Reilly MP, Arepally G, Weisel JW, Nagaswami C, Cines DB, Sachais BS: Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia. Blood 105(1): 131-8, Jan 2005.

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Last updated: 09/05/2018
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