Steven J. Siegel

faculty photo
Adjunct Professor of Psychiatry
Attending Physician, Department of Psychiatry, Presbyterian Medical Center
Attending Physician, Department of Psychiatry, Hospital of the University of Pennsylvania
Member, Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania Perelman School of Medicine
Director, Clinical Neurosciences Training Program, University of Pennsylvania Perelman School of Medicine
Director, Translational Neuroscience Program, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine
Associate Director, Clinical and Translational Science Awards (CTSA) Educational Programs and Masters in Translational Research, University of Pennsylvania
Advisory Board, Penn Medicine Neuroscience Center
Department: Psychiatry

Contact information
Rm 2202
125 S. 31st street
Translational Research Building
Philadelphia, PA 19104-4283
Office: 215 573 0278
Graduate Group Affiliations
B.A. (Neuroscience)
Colgate University, 1986.
Ph.D. (Neurobiology)
Mount Sinai School of Medicine, 1994.
Mount Sinai School of Medicine, 1996.
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Description of Itmat Expertise

Dr. Siegel is interested in the design and development of surgically implantable long-term delivery systems for the treatment of schizophrenia and other major neuropsychiatry conditions. His laboratory also develops and validates animal models of schizophreenia and Autism to foster better understanding of the disorders and their treatment.

Selected Publications

Choi, C. H., Schoenfeld, B. P., Weisz, E. D., Bell, A. J., Chambers, D. B., Hinchey, J., Choi, R. J., Hinchey, P., Kollaros, M., Gertner, M. J., Ferrick, N. J., Terlizzi, A. M., Yohn, N., Koenigsberg, E., Liebelt, D. A., Zukin, R. S., Woo, N. H., Tranfaglia, M. R., Louneva, N., Arnold, S. E., Siegel, S. J., Bolduc, F. V., McDonald, T. V., Jongens, T. A., McBride, S. M.: PDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of fragile X syndrome. J Neurosci 35(1): 396-408, 2015.

Banerjee, A., Wang, H. Y., Borgmann-Winter, K. E., MacDonald, M. L., Kaprielian, H., Stucky, A., Kvasic, J., Egbujo, C., Ray, R., Talbot, K., Hemby, S. E., Siegel, S. J., Arnold, S. E., Sleiman, P., Chang, X., Hakonarson, H., Gur, R. E., Hahn, C. G.: Src kinase as a mediator of convergent molecular abnormalities leading to NMDAR hypoactivity in schizophrenia. Mol Psychiatry 20(9): 1091-100, 2015.

White, R. S., Siegel, S. J.: Cellular and circuit models of increased resting-state network gamma activity in schizophrenia. Neuroscience 2015.

Tatard-Leitman, V. M., Jutzeler, C. R., Suh, J., Saunders, J. A., Billingslea, E. N., Morita, S., White, R., Featherstone, R. E., Ray, R., Ortinski, P. I., Banerjee, A., Gandal, M. J., Lin, R., Alexandrescu, A., Liang, Y., Gur, R. E., Borgmann-Winter, K. E., Carlson, G. C., Hahn, C. G., Siegel, S. J.: Pyramidal cell selective ablation of N-methyl-d-aspartate receptor 1 causes increase in cellular and network excitability. Biol Psychiatry 77(6): 556-68, 2015.

Sobota, R., Mihara, T., Forrest, A., Featherstone, R. E., Siegel, S. J.: Oxytocin reduces amygdala activity, increases social interactions, and reduces anxiety-like behavior irrespective of NMDAR antagonism. Behav Neurosci 129(4): 389-98, 2015.

Featherstone, R. E., Nagy, L. R., Hahn, C. G., Siegel, S. J.: Juvenile exposure to ketamine causes delayed emergence of EEG abnormalities during adulthood in mice. Drug Alcohol Depend 134: 123-7, 2014.

Lin, R.E. , Ambler, L., Billingslea, E. N., Suh, J.D., Cho, M., Ciscci, A., Tatard-leitman, V., Featherstone, R. E., Siegel, S J: Differential sensitivity of the Brattleboro rat to glutamatergic and dopaminergic perturbation. Journal of Psychiatry and Brain Functions 1(3): 1-9, 2014.

Goffin, D., Brodkin, E. S., Blendy, J. A., Siegel, S. J., Zhou, Z.: Cellular origins of auditory event-related potential deficits in Rett syndrome. Nat Neurosci 17(6): 804-6, 2014.

Forrest, A. D., Coto, C. A., Siegel, S. J.: Animal Models of Psychosis: Current State and Future Directions. Curr Behav Neurosci Rep 1(2): 100-116, 2014.

Featherstone, R. E., Shin, R., Kogan, J. H., Liang, Y., Matsumoto, M., Siegel, S. J.: Mice with subtle reduction of NMDA NR1 receptor subunit expression have a selective decrease in mismatch negativity: Implications for schizophrenia prodromal population. Neurobiol Dis 73C: 289-295, 2014.

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Last updated: 04/05/2016
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