Joel S. Bennett

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Professor of Medicine
Department: Medicine

Contact information
Division of Hematology-Oncology
814 BRB II/III
421 Curie Boulevard/6160
Philadelphia, PA 19104
Office: (215) 573-3280
Fax: (215) 573-7039
Graduate Group Affiliations
Education:
B.S. (Pre-med)
University of Michigan , 1963.
M.D. (Medicine (Cum laude)
University of Michigan, 1967.
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Description of Research Expertise

Integrin function is essential for normal platelet adhesion and aggregation and participates i n the formation of the arterial thrombi that are responsible for heart attacks and strokes. The activation state of platelet integrins is regulated by platelet agonists, but the structural basis for this regulation is not known. Our studies indicate that helix-helix interactions involving the transmembrane and membrane-proximal cytoplasmic domain segments play an essential role in regulating the function of both beta 1 and beta 3 integrins. The current focus of the laboratory is to use biophysical and molecular biologic techniques to characterize these interactions in detail and to use this information to design potential anti-thrombotic agents.

Description of Itmat Expertise

Dr. Bennett's research interests are hemostasis and thrombosis, platelet biochemistry and physiology, integrin structure and function, and cell adhesion.

Selected Publications

Mravic, M., Hu, H., Lu, Z., Bennett, J.S., Sanders, C.R., Orr, A.W., and DeGrado, W.F.: De novo designed transmembrane peptides activating the 51 integrin. Protein : De novo designed transmembrane peptides activating the 51 integrin. Protein Engineering, Design & Selection. 2018.

Bennett, J.S.: Are anti-platelet agents beneficial in Essential Thrombocythemia? Maybe yes, probably no. Ann. Int. Med. 167: 206-207, 2017.

Bennett, J.S.: Clinical dilemma: Experts make the call. ASH Clinical News. 3(05): 34, 2017.

Bennett, J.S. : IIb3 (GPIIb/IIIa) structure and function. Platelets in Thrombotic and Non-Thrombotic Disorders. Gresele, P., Lopez, J.A., Kleiman, N.S., and Page, C.P., eds.) (eds.). Springer, Switzerland, 2: 99-109, 2017.

Höök, P., Litvinov, R.I., Kim, O.V., Xu, S., Bennett, J.S., Alber, M.S., and Weisel, J.W: Strong binding of platelet integrin IIb3 to fibrin clots: Potential target to destabilize thrombi. Scientific Reports 7, 2017.

Kononova, O., Litvinov, R.I., Blokhin, D.S., Klochkov, V.V., Weisel, J.W., Bennett, J.S., Barsegov, V.: Mechanistic basis for the binding of RGD- and AGDV-peptides to the platelet integrin IIb3. Biochemistery 56, 2017.

Fong, F.P., Zhu, H., Span, L.M., Moore, D.T., Yoon, K., Tamura, R., Yin, H.H., DeGrado, W.F., and Bennett, J.S.: Directly activating IIb3 initiates outside-in signaling by causing IIb3 clustering. J. Bio. Chem/ 291, 2016.

Abrams, C.S., Shattil, S.J., and Bennett, J.S.: Acquired qualitative platelet disorders due to drugs, diseases, and foods. Hematology. Lichtman, M.A., Beutler, E., Kipps, T.J., Seligsohn, U., Kaushansky, K., and Prchal, J., eds. (eds.). McGraw-Hi;; 9, 2016.

Litvinov, R.I., Farrell, D.H., Weisel, J.W., and Bennett, J.S.: The platelet integrin IIb3 differentially interacts with fibrin versus fibrinogen. J. Biol. Chem. 291, 2016.

Bennett, J.S.: Editorial: Shedding new light on the platelet storage lesion. Arterioscler. Thromb. Vasc. Biol. 36: 1715-1716, 2016.

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Last updated: 11/02/2018
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