Gerald B. W. Wertheim

faculty photo
Associate Professor of Clinical Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
Department of Pathology and Laboratory Medicine
Children's Hospital of Philadelphia
5199B Main Building
5th Floor
3401 Civic Center Boulevard
Philadelphia, PA 19104
Office: 267-970-5918
Fax: 215-590-1736
Education:
BS (Chemistry)
Yale University, New Haven CT, 1994.
PhD (Cancer Biology)
University of Pennsylvania School of Medicine, 2004.
MD (Medicine)
University of Pennsylvania School of Medicine, 2005.
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Description of Itmat Expertise

DNA methylation
Acute myeloid leukemia prognosis

Selected Publications

Rosenthal J, Naqvi AS, Luo M, Wertheim G, Paessler M, Thomas-Tikhonenko A, Rheingold SR, Pillai V: Heterogeneity of surface CD19 and CD22 expression in B lymphoblastic leukemia. Am J Hematol July 2018 Notes: Epub ahead of print.

Krevvata M, Shan X, Zhou C, Dos Santos C, Habineza Ndikuyeze G, Secreto A, Glover J, Trotman W, Brake-Silla G, Nunez-Cruz S, Wertheim G, Ra HJ, Griffiths E, Papachristou C, Danet-Desnoyers G, Carroll M: Cytokines increase engraftment of human acute myeloid leukemia cells in immunocompromised mice but not engraftment of human myelodysplastic syndrome cells. Haematologica 103(6): 959-971, June 2018.

Sarthy J, Zha J, Babushok D, Shenoy A, Fan JM, Wertheim G, Himebauch A, Munchel A, Taraseviciute A, Yang S, Shima H, Narumi S, Meshinchi S, Olson TS: Poor outcome with hematopoietic stem cell transplantation for bone marrow failure and MDS with severe MIRAGE syndrome phenotype. Blood Adv 2(2): 120-125, Jan 2018.

Bu Y, Yoshida A, Chitnis N, Altman A, Tameire F, Oran A, Gennaro v, Armeson K, McMahon S, Wertheim G, Dang C, Ruggero D, Koumenis C, Fuchs S, Diehl JA: PERK-miR-211 integrates oncogenic signaling with circadian oscillation and protein synthesis. Nature Cell Biology 20(1): 104-115, Jan 2018.

Ding YY, Stern JW, Jubelirer TF, Wertheim GB, Li F, Chang F, Gu Z, Mullighan CG, Li Y, Harvey RC, Chen IM, Willman CL, Hunger SP, Li MM, Tasian SK: Clinical efficacy of ruxolitinib and chemotherapy in a child with Philadelphia chromosome-like acute lymphoblastic leukemia with GOLGA5-JAK2 fusion and induction failure. Haematologica 2018 Notes: Epub ahead of print.

Hurtz C, Tasian SK, Wertheim G, Ruggeri B, Stubbs MC, Perl AE, Carroll M: Redundant JAK, SRC and PI3 Kinase Signaling Pathways Regulate Cell Survival in Human Ph-like ALL Cell Lines and Primary Cells. 59th Annual American Society for Hematology Meeting and Exposition, Atlanta, GA December 2017 Notes: Oral Presentation.

Lalonde E, Wertheim G, Li MM: Clinical Impact of Genomic Information in Pediatric Leukemia. Front Pediatr 5: 263, December 2017.

Li J, Wertheim G, Paessler M, Pillai V: Flow cytometry in pediatric hematopoietic malignancies. Clinics in Laboratory Medicine 37: 879-893, December 2017.

Pajcini KV, Xu L, Shao L, Petrovic J, Palasiewicz K, Ohtani Y, Bailis W, Lee C, Wertheim GB, Rajeswaran M, Musuthamy N, Li Y, Meijerink JPP, Blacklow SC, Faryabi RB, Cherry S and Pear WS: MafB is a novel enhancer of oncogenic Notch signaling in T-cell acute lymphoblastic leukemia. Science Signaling 10(505), November 2017.

Grenstein LAV, Coughlin CC, Flynn AT, Pillai V, Boos MD, Wertheim GW, Treat JR, Teachey DT: Severe Mucha-Habermann-like Ulceronecrotic Skin Disease in T-cell ALL Responsive to Basiliximab and Stem Cell Transplant Pediatric Dermatology 34(5): e265-e270, September 2017.

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Last updated: 09/10/2018
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