John B. Hogenesch

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Adjunct Professor of Pharmacology
Member, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine
Associate Director, Institute for Biomedical Informatics
Vice Chair, Research, Department of Systems Pharmacology and Translational Therapeutics
Department: Pharmacology

Contact information
Smilow Translational Research Center 10-124
3400 Civic Center Blvd., Bldg. 421
Philadelphia, PA 19104-5158
Office: 484-842-4232
B.A. (History)
University of Southern California, 1989.
B.S. (Biology)
University of Southern California, 1991.
Ph.D. (Neuroscience)
Northwestern University, 1999.
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Description of Research Expertise

Our laboratory studies the mammalian circadian clock using genomic and computational tools. We use these tools to discover new clock genes, learn how the clock keeps time, and how it coordinates rhythms in physiology and behavior. This clock research drives development of genomic and computational methods that we apply to other areas of biology. Finally, we recognize biological complexity and conduct this research at the network, rather than single gene, level.

Description of Itmat Expertise

Dr. Hogenesch studies the biology of circadian clocks in the mammal and the application of functional genomics tools to understanding genome function.

Selected Publications

DeBruyne Jason P, Baggs Julie E, Sato Trey K, Hogenesch John B: Ubiquitin ligase Siah2 regulates RevErbĪ± degradation and the mammalian circadian clock. Proceedings of the National Academy of Sciences of the United States of America 112(40): 12420-5, Oct 2015.

Jang Christopher, Lahens Nicholas F, Hogenesch John B, Sehgal Amita: Ribosome profiling reveals an important role for translational control in circadian gene expression. Genome research Sep 2015.

Hayer Katharina E, Pizarro Angel, Lahens Nicholas F, Hogenesch John B, Grant Gregory R: Benchmark analysis of algorithms for determining and quantifying full-length mRNA splice forms from RNA-seq data. Bioinformatics (Oxford, England) Sep 2015.

Altman Brian J, Hsieh Annie L, Sengupta Arjun, Krishnanaiah Saikumari Y, Stine Zachary E, Walton Zandra E, Gouw Arvin M, Venkataraman Anand, Li Bo, Goraksha-Hicks Pankuri, Diskin Sharon J, Bellovin David I, Simon M Celeste, Rathmell Jeffrey C, Lazar Mitchell A, Maris John M, Felsher Dean W, Hogenesch John B, Weljie Aalim M, Dang Chi V: MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells. Cell metabolism Sep 2015.

Lee Yool, Jang A Reum, Francey Lauren J, Sehgal Amita, Hogenesch John B: KPNB1 mediates PER/CRY nuclear translocation and circadian clock function. eLife 4, Aug 2015.

Wolman Marc A, Jain Roshan A, Marsden Kurt C, Bell Hannah, Skinner Julianne, Hayer Katharina E, Hogenesch John B, Granato Michael: A Genome-wide Screen Identifies PAPP-AA-Mediated IGFR Signaling as a Novel Regulator of Habituation Learning. Neuron 85(6): 1200-11, Mar 2015.

Anton Lauren, Olarerin-George Anthony O, Hogenesch John B, Elovitz Michal A: Placental Expression of miR-517a/b and miR-517c Contributes to Trophoblast Dysfunction and Preeclampsia. PloS one 10(3): e0122707, March 2015.

Olarerin-George Anthony O, Hogenesch John B: Assessing the prevalence of mycoplasma contamination in cell culture via a survey of NCBI's RNA-seq archive. Nucleic acids research 43(5): 2535-42, Mar 2015.

Banerjee Santanu, Hayer Katharina, Hogenesch John B, Granato Michael: Zebrafish foxc1a drives appendage-specific neural circuit development. Development (Cambridge, England) 142(4): 753-62, Feb 2015.

Li Jiajia, Grant Gregory R, Hogenesch John B, Hughes Michael E: Considerations for RNA-seq analysis of circadian rhythms. Methods in enzymology 551: 349-67, 2015.

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Last updated: 10/13/2015
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