John B. Hogenesch

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Member, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine
Associate Director, Institute for Biomedical Informatics
Vice Chair, Research, Department of Systems Pharmacology and Translational Therapeutics
Department: Pharmacology

Contact information
Smilow Translational Research Center 10-124
3400 Civic Center Blvd., Bldg. 421
Philadelphia, PA 19104-5158
Office: 484-842-4232
B.A. (History)
University of Southern California, 1989.
B.S. (Biology)
University of Southern California, 1991.
Ph.D. (Neuroscience)
Northwestern University, 1999.
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Description of Research Expertise

Our laboratory studies the mammalian circadian clock using genomic and computational tools. We use these tools to discover new clock genes, learn how the clock keeps time, and how it coordinates rhythms in physiology and behavior. This clock research drives development of genomic and computational methods that we apply to other areas of biology. Finally, we recognize biological complexity and conduct this research at the network, rather than single gene, level.

Description of Itmat Expertise

Dr. Hogenesch studies the biology of circadian clocks in the mammal and the application of functional genomics tools to understanding genome function.

Selected Publications

Wolman Marc A, Jain Roshan A, Marsden Kurt C, Bell Hannah, Skinner Julianne, Hayer Katharina E, Hogenesch John B, Granato Michael: A Genome-wide Screen Identifies PAPP-AA-Mediated IGFR Signaling as a Novel Regulator of Habituation Learning. Neuron 85(6): 1200-11, Mar 2015.

Anton Lauren, Olarerin-George Anthony O, Hogenesch John B, Elovitz Michal A: Placental Expression of miR-517a/b and miR-517c Contributes to Trophoblast Dysfunction and Preeclampsia. PloS one 10(3): e0122707, March 2015.

Olarerin-George Anthony O, Hogenesch John B: Assessing the prevalence of mycoplasma contamination in cell culture via a survey of NCBI's RNA-seq archive. Nucleic acids research 43(5): 2535-42, Mar 2015.

Banerjee Santanu, Hayer Katharina, Hogenesch John B, Granato Michael: Zebrafish foxc1a drives appendage-specific neural circuit development. Development (Cambridge, England) 142(4): 753-62, Feb 2015.

Li Jiajia, Grant Gregory R, Hogenesch John B, Hughes Michael E: Considerations for RNA-seq analysis of circadian rhythms. Methods in enzymology 551: 349-67, 2015.

Manderfield Lauren J, Engleka Kurt A, Aghajanian Haig, Gupta Mudit, Yang Steven, Li Li, Baggs Julie E, Hogenesch John B, Olson Eric N, Epstein Jonathan A: Pax3 and hippo signaling coordinate melanocyte gene expression in neural crest. Cell reports 9(5): 1885-95, Dec 2014.

Zhang Ray, Lahens Nicholas F, Ballance Heather I, Hughes Michael E, Hogenesch John B: A circadian gene expression atlas in mammals: Implications for biology and medicine. Proceedings of the National Academy of Sciences of the United States of America 111(45): 16219-24, Nov 2014.

Perez-Santángelo Soledad, Mancini Estefanía, Francey Lauren J, Schlaen Ruben Gustavo, Chernomoretz Ariel, Hogenesch John B, Yanovsky Marcelo J: Role for LSM genes in the regulation of circadian rhythms. Proceedings of the National Academy of Sciences of the United States of America 111(42): 15166-71, Oct 2014.

Pellegrino Renata, Kavakli Ibrahim Halil, Goel Namni, Cardinale Christopher J, Dinges David F, Kuna Samuel T, Maislin Greg, Van Dongen Hans P A, Tufik Sergio, Hogenesch John B, Hakonarson Hakon, Pack Allan I: A Novel BHLHE41 Variant is Associated with Short Sleep and Resistance to Sleep Deprivation in Humans. Sleep 37(8): 1327-36, August 2014.

Lahens Nicholas F, Kavakli Ibrahim Halil, Zhang Ray, Hayer Katharina, Black Michael B, Dueck Hannah, Pizarro Angel, Kim Junhyong, Irizarry Rafael, Thomas Russell S, Grant Gregory R, Hogenesch John B: IVT-seq reveals extreme bias in RNA-sequencing. Genome biology 15(6): R86, Jun 2014.

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Last updated: 07/13/2015
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