Michael Chorny

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Research Associate Professor of Pediatrics
Associate Director, Center for Targeted Therapeutics & Translational Nanomedicine of the ITMAT (Institute of Translational Medicine & Therapeutics)
Department: Pediatrics

Contact information
The Abramson Pediatric Research Center, Suite 702G
The Children's Hospital of Philadelphia
3615 Civic Center Blvd.
Philadelphia, PA 19104
Office: 215-590-3063
Education:
BPharm (Pharmaceutical sciences)
The Hebrew University of Jerusalem, Israel, 1996.
MS (Pharmaceutical sciences)
The Hebrew University of Jerusalem, Israel, 1997.
PhD (Pharmaceutical sciences)
The Hebrew University of Jerusalem, Israel, 2004.
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Description of Itmat Expertise

Design of drug, gene, protein and cell delivery systems
Magnetically targeted therapy of arterial restenosis
Nanocarrier-based site-specific gene delivery methods

Selected Publications

I. Fishbein, D. Guerrero, I.S. Alferiev, J. Foster, N. Minutolo, M. Chorny, A. Mas Monteys, K. Driesbaugh, C. Nagaswami, R.J. Levy: Stent-based delivery of adeno-associated viral vectors with sustained vascular transduction and iNOS-mediated inhibition of in-stent restenosis. Gene Therapy Aug 2017.

M.R. Battig, I. Fishbein, R.J. Levy, I.S. Alferiev, D. Guerrero, M. Chorny: Optimizing endothelial cell functionalization for cell therapy of vascular proliferative disease using a direct contact co-culture system. Drug Delivery and Translational Research Jul 2017.

I. Fishbein, T. Welch, D.T. Guerrero, I.S. Alferiev, R.F. Adamo, M. Chorny, R.K. Gupte, Y. Tang, R.J. Levy: Paraffin processing of stented arteries using a postfixation dissolution of metallic and polymeric stents. Cardiovascular Patholology 25(6): 483-88, Sep 2016.

R.F. Adamo, I. Fishbein, K. Zhang, J. Wen, R.J. Levy, I.S. Alferiev, M. Chorny: Magnetically enhanced cell delivery for accelerating recovery of the endothelium in injured arteries. Journal of Controlled Release 222: 169-75, Jan 2016.

I.S. Alferiev, R. Iyer, J.L. Croucher, R.F. Adamo, K. Zhang, J.L. Mangino, V. Kolla, I. Fishbein, G.M. Brodeur, R.J. Levy, M. Chorny: Nanoparticle-mediated delivery of a rapidly activatable prodrug of SN-38 for neuroblastoma therapy. Biomaterials 51: 22-9, May 2015.

R. Iyer*, J.L. Croucher*, M. Chorny*, J.L. Mangino, I.S. Alferiev, R.J. Levy, V. Kolla, G.M. Brodeur: Nanoparticle delivery of an SN38 conjugate is more effective than irinotecan in a mouse model of neuroblastoma. Cancer Letters 360(2): 205-12, May 2015 Notes: (* equal contribution).

P.C. Naha, A. Al Zaki, E. Hecht, M. Chorny, P. Chhour, E. Blankemeyer, D.M. Yates, W.R.T. Witschey, H.I. Litt, A. Tsourkas, D.P. Cormode: Dextran coated bismuth-iron oxide nanohybrid contrast agents for computed tomography and magnetic resonance imaging. Journal of Materials Chemistry. B, Materials for Biology and Medicine 2: 8239-48, Oct 2014.

I. Fishbein, S.P. Forbes, R.F. Adamo, M. Chorny, R.J. Levy, I.S. Alferiev: Vascular gene transfer from metallic stent surfaces using adenoviral vectors tethered through hydrolysable cross-linkers. Journal of Visualized Experiments 90: e51653, Aug 2014.

M.D. Howard, E.D. Hood, C.F. Greineder, I.S. Alferiev, M. Chorny, V. Muzykantov: Targeting to endothelial cells augments the protective effect of novel dual bioactive antioxidant/anti-inflammatory nanoparticles. Molecular Pharmaceutics 11(7): 2262-70, Jul 2014.

E.D. Hood, M. Chorny, C.F. Greineder, I.S. Alferiev, R.J. Levy, V.R. Muzykantov: Endothelial targeting of nanocarriers loaded with antioxidant enzymes for protection against vascular oxidative stress and inflammation. Biomaterials 35(11): 3708-15, Apr 2014.

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Last updated: 09/15/2017
The Trustees of the University of Pennsylvania