Manzar Ashtari

faculty photo
Research Associate Professor of Ophthalmology
Director of CNS Imaging, Center for Advanced Retinal and Ocular Therapeutics (CAROT), Department of Ophthalmology, University of Pennsylvania
Department: Ophthalmology

Contact information
Center for Advanced Retinal and Ocular Therapeutics (CAROT)
207A Anatomy-Chemistry Building
3620 Hamilton Walk
Philadelphia, PA 19104
Office: 516-770-3132
Graduate Group Affiliations
Education:
BS (Physics)
Tehran University, Tehran, Iran, 1974.
MS (Nuclear Engineering)
Massachusetts Institute of Technology , 1977.
PhD (Nuclear Engineering)
Massachusetts Institute of Technology , 1982.
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Description of Itmat Expertise

Application of advanced functional and structural imaging to pediatric and adolescent population. Imaging application to clinical population to identify disease biomarkers.

Selected Publications

Silson EH, Aleman TS, Willett A, Serrano LW, Pearson DJ, Rauschecker AM, Maguire AM, Baker CI, Bennett J, Ashtari M: Comparing Clinical Perimetry and Population Receptive Field Measures in Patients with Choroideremia. Investigative ophthalmology & visual science 59(8): 3249-3258, Jul 2018.

Ashtari M, Nikonova ES, Marshall KA, Young GJ, Aravand P, Pan W, Ying GS, Willett AE, Mahmoudian M, Maguire AM, Bennett J: The Role of the Human Visual Cortex in Assessment of the Long-Term Durability of Retinal Gene Therapy in Follow-on RPE65 Clinical Trial Patients. Ophthalmology 124(6): 873-883, Jun 2017.

Betancourt LM, Avants B, Farah MJ, Brodsky NL, Wu J, Ashtari M, Hurt H: Effect of socioeconomic status (SES) disparity on neural development in female African-American infants at age 1 month. Developmental Science 19(6): 947-956, Nov 2016.

Bennett J, Wellman J, Marshall KA, McCague S, Ashtari M, DiStefano-Pappas J, Elci OU, Chung DC, Sun Ji, Wright JF, Cross DR, Aravand P, Cyckowski LL, Bennicelli JL, Mingozzi F, Auricchio A, Pierce EA, Ruggiero J, Leroy BP, Simonelli F, High KA, Maguire AM: Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations: a follow-on phase 1 trial. Lancet (London, England) 388(10045): 661-72, Aug 2016.

Betancourt LM, Avants B, Farah MJ, Brodsky NL, Wu J, Ashtari M, Hurt H : Effect of socioeconomic status (SES) disparity on neural development in female African-American infants at age 1 month. Dev Sci Oct 2015 Notes: Epub ahead of print.

Ashtari M, Zhang H, Cook PA, Cyckowski LL, Shindler KS, Marshall KA, Aravand P, Vossough A, Gee JC, Maguire AM, Baker CI, Bn: Plasticity of the human visual system after retinal gene therapy in patients with Leber's congenital amaurosis. Sci Transl Med 7(296): 296ra110, Jul 2015.

Featured News: Technologies are allowing doctors to do what was once unheard of: Restore blind people’s sight. Now the real challenges begin. Nature International Weekly Journal of Science 513, Sep 2014 Notes: http://www.nature.com/news/curing-blindness-vision-quest-1.15875.

Jean Bennett, Manzar Ashtari, Kathleen Marshall, Daniel Chung, Alberto Auricchio, Francesca Simonelli, Bart Leroy, Junwei Sun, Kenneth Schindler, Albert Maguire: Response of the Visual Pathways in the Human Brain to Gene Therapy. ISER XXI Biennial Meeting, San Francisco, CA Jul 2014 Notes: Oral presentation.

Manzar Ashtari, Gary Hui Zhang, Laura Cyckowski, Philip Cook, Amanda Viands, Kathleen Marshall, James Gee, Albert Maguire, Jean Bennett: Plasticity of the Human Visual Pathways Formed by Ocular Gene Therapy, Washington, DC. Proceedings of the International Society for Magnetic Resonance in Medicine May 2014 Notes: Poster presentation.

Manzar Ashtari, Amanda Viands, Kathleen Marshall, Kenneth Shindler, Albert Maguire, and Jean Bennett: Long-Lasting Vision Following One-Time Gene Therapy: Partnership of Brain and Retina Revealed By fMRI. 17th Annual Meeting of the American Society of Gene & Cell Therapy May 2014 Notes: Oral presentation.

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Last updated: 10/08/2019
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