Fernanda Oliveira Novais
Research Assistant Professor, Pathobiology, University of Pennsylvania School of Veterinary Medicine
Publications
Education:
MSc (Parasitology/Pathology)
Federal University of Bahia/FIOCRUZ-BA, Brazil, 2006.
PhD (Parasitology/Pathology)
Federal University of Bahia/FIOCRUZ-BA, Brazil, 2011.
MSc (Parasitology/Pathology)
Federal University of Bahia/FIOCRUZ-BA, Brazil, 2006.
PhD (Parasitology/Pathology)
Federal University of Bahia/FIOCRUZ-BA, Brazil, 2011.
Post-Graduate Training
Post-doctoral Fellow, University of Pennsylvania School of Veterinary Medicine, 2011-2016.
Permanent linkPost-doctoral Fellow, University of Pennsylvania School of Veterinary Medicine, 2011-2016.
Description of Research Expertise
Description:The Novais laboratory research focuses on how environmental signals determine CD8 T cell function. We are particularly interested in how cutaneous infection with the protozoan parasite leishmania influences the phenotype CD8 T cells exhibit during disease. Currently our laboratory is interested in addressing three major questions:
1) How does oxygen availability determine CD8 T cell function?
2) What are the transcription factors involved in CD8 T cell phenotype in different tissues?
3) How does the skin microbiota influence CD8 T cell function?
Selected Publications
Carvalho, A. M., Novais, F. O., Paixao, C. S., de Oliveira, C. I., Machado, P. R. L., Carvalho, L. P., Scott, P., Carvalho, E. M.: Glyburide, a NLRP3 inhibitor, decreases inflammatory response and is a candidate to reduce pathology in Leishmania braziliensis infection. J Invest Dermatol 140(1): 246-249 e2, 2020.Campos, T. M., Novais, F. O., Saldanha, M., Costa, R., Lordelo, M., Celestino, D., Sampaio, C., Tavares, N., Arruda, S., Machado, P., Brodskyn, C., Scott, P., Carvalho, E. M., Carvalho, L. P.: Granzyme b produced by natural killer cells enhances inflammatory response and contributes to the immunopathology of cutaneous leishmaniasis. J Infect Dis 2019.
Amorim, C. F., Novais, F. O., Nguyen, B. T., Misic, A. M., Carvalho, L. P., Carvalho, E. M., Beiting, D. P., Scott, P.: Variable gene expression and parasite load predict treatment outcome in cutaneous leishmaniasis. Sci Transl Med 11(519), 2019.
Novais, F. O., Wong, A. C., Villareal, D. O., Beiting, D. P., Scott, P.: CD8(+) T cells lack local signals to produce IFN-gamma in the skin during Leishmania infection. J Immunol 200(5): 1737-1745, 2018.
Davis, R. E., Sharma, S., Conceicao, J., Carneiro, P., Novais, F., Scott, P., Sundar, S., Bacellar, O., Carvalho, E. M., Wilson, M. E.: Phenotypic and functional characteristics of HLA-DR(+) neutrophils in Brazilians with cutaneous leishmaniasis. J Leukoc Biol 101(3): 739-749, 2017.
Novais, F. O., Carvalho, A. M., Clark, M. L., Carvalho, L. P., Beiting, D. P., Brodsky, I. E., Carvalho, E. M., Scott, P.: CD8+ T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1beta production. PLoS Pathog 13(2): e1006196, 2017.
Gimblet, C., Meisel, J. S., Loesche, M. A., Cole, S. D., Horwinski, J., Novais, F. O., Misic, A. M., Bradley, C. W., Beiting, D. P., Rankin, S. C., Carvalho, L. P., Carvalho, E. M., Scott, P., Grice, E. A.: Cutaneous leishmaniasis induces a transmissible dysbiotic skin microbiota that promotes skin inflammation. Cell Host Microbe 22(1): 13-24 e4, 2017.
Christensen, S. M., Dillon, L. A., Carvalho, L. P., Passos, S., Novais, F. O., Hughitt, V. K., Beiting, D. P., Carvalho, E. M., Scott, P., El-Sayed, N. M., Mosser, D. M.: Meta-transcriptome profiling of the human-Leishmania braziliensis cutaneous lesion. PLoS Negl Trop Dis 10(9): e0004992, 2016.
Scott, P., Novais, F. O.: Cutaneous leishmaniasis: immune responses in protection and pathogenesis. Nat Rev Immunol 16(9): 581-92, 2016.
Crosby, E. J., Clark, M., Novais, F. O., Wherry, E. J., Scott, P.: Lymphocytic choriomeningitis virus expands a population of NKG2D+CD8+ T cells that exacerbates disease in mice coinfected with Leishmania major. J Immunol 195(7): 3301-10, 2015.