Sean Hennessy

faculty photo
Associate Professor of Epidemiology in Biostatistics and Epidemiology
Director, Ambulatory Drug Use and Effects Program, University of Pennsylvania Health System
Co-Director, Global Health Partnership with Universidad Peruana Cayetano Heredia
Director, Pharmacoepidemiology Concentration of the MSCE Program, Perelman School of Medicine at the University of Pennsylvania
Director, Center for Pharmacoepidemiology Research and Training (CPeRT), Perelman School of Medicine at the University of Pennsylvania
Department: Biostatistics and Epidemiology

Contact information
University of Pennsylvania
423 Guardian Drive
803 Blockley Hall
Philadelphia, PA 19104-6021
Office: 215-898-9112
Fax: 215-573-5315
Graduate Group Affiliations
Education:
BS (Pharmacy)
Philadelphia College of Pharmacy and Science, 1989.
PharmD (Clinical Pharmacy)
Philadelphia College of Pharmacy and Science, 1990.
MSCE (Clinical Epidemiology)
University of Pennsylvania School of Medicine, 1996.
PhD (Epidemiology with Biostatistics minor)
University of Pennsylvania, 2002.
Permanent link
 

Description of Research Expertise

Dr. Hennessy’s primary field of interest is pharmacoepidemiology, which is the study of the health effects of drugs and other medical products in populations. He co-led a seminal pair of studies demonstrating the effectiveness and safety of the SA14-14-2 vaccine for Japanese encephalitis that has since led to the immunization of millions of children per year in countries including North and South Korea, Nepal, India, Cambodia and Sri Lanka. He also evaluated an early approach to using medical insurance data to improve prescribing—and found it ineffective despite its federal mandate. This contributed to the omission of drug utilization review programs from Medicare Part D. His research has produced crucial knowledge about the cardiovascular safety of many widely-used drugs for mental health conditions in including ADHD, depression, and schizophrenia. He has identified a survival benefit of potassium supplementation in diuretic users and studied serious health consequences of drug-drug interactions involving high-risk drugs including anticoagulants, antidiabetic agents and antiplatelet agents. He also collaborates on studies aimed at improving pharmacoepidemiology research methods.

Dr. Hennessy is a past scientific chair and past president of the International Society for Pharmacoepidemiology, and has served on FDA’s Drug Safety and Risk Management In 2015 he begans a three-year term on the board of directors of the American Society for Clinical Pharmacology and Therapeutics. He is a co-editor of the books Pharmacoepidemiology, 5th edition and Textbook of Pharmacoepidemiology, 2nd edition and is Editor for the Americas of the journal Pharmacoepidemiology and Drug Safety. Dr. Hennessy received the 2005 Young Alumnus Award from the University of the Sciences in Philadelphia, the 2007 Leon I Goldberg Young Investigator Award from the American Society for Clinical Pharmacology and Therapeutics, and the 2013 Samuel Martin Health Evaluation Sciences Research Award from the University of Pennsylvania Perelman School of Medicine.

Description of Other Expertise

Dr. Hennessy directs Penn’s Center for Pharmacoepidemiology Research and Training (CPeRT) and Penn’s pharmacoepidemiology training programs. Dr. Hennessy teaches clinical epidemiology to medical and graduate students and is active in promoting evidence-based practice at Penn Medicine, co-chairing its Drug Use and Effects Committee and serving on its Pharmacy and Therapeutics Committee. Dr. Hennessy’s clinical program has received two Quality and Safety Awards from the University of Pennsylvania Health System.

Description of Itmat Expertise

Dr. Hennessy’s primary field of interest is pharmacoepidemiology, which is the study of the health effects of drugs and other medical products in populations. He co-led a seminal pair of studies demonstrating the effectiveness and safety of a vaccine for Japanese encephalitis that has since led to the immunization of millions of children per year in North and South Korea, Nepal, India, Cambodia and Sri Lanka. He also evaluated an early approach to using medical insurance data to improve prescribing—and found it ineffective despite its federal mandate. His research has produced crucial knowledge about the cardiovascular safety of many widely-used drugs for mental health conditions in including ADHD, depression, schizophrenia. He has identified a survival benefit of potassium supplementation in diuretic users and studied serious health consequences of drug-drug interactions involving high-risk drugs including anticoagulants, antidiabetic agents and antiplatelet agents. He also conducts studies aimed at improving pharmacoepidemiology research methods. In addition to his research, Dr. Hennessy directs Penn’s Center for Pharmacoepidemiology Research and Training (CPeRT) and Penn’s pharmacoepidemiology training programs.

Dr. Hennessy teaches clinical epidemiology to medical and graduate students and is active in promoting evidence-based practice at Penn Medicine, co-chairing its Drug Use and Effects Committee and serving on its Pharmacy and Therapeutics Committee. Dr. Hennessy’s clinical program has received two Quality and Safety Awards from the University of Pennsylvania Health System. Dr. Hennessy is a past scientific chair and past president of the International Society for Pharmacoepidemiology, and has served on FDA’s Drug Safety and Risk Management Advisory Committee. He begins a three-year term on the board of directors of the American Society for Clinical Pharmacology and Therapeutics in March 2015. He is a co-editor of the books Pharmacoepidemiology, 5th edition and Textbook of Pharmacoepidemiology, 2nd edition and is Editor for the Americas of the journal Pharmacoepidemiology and Drug Safety.

Dr. Hennessy received the 2005 Young Alumnus Award from the University of the Sciences in Philadelphia, the 2007 Leon I Goldberg Young Investigator Award from the American Society for Clinical Pharmacology and Therapeutics, and the 2013 Samuel Martin Health Evaluation Sciences Research Award from the University of Pennsylvania Perelman School of Medicine.

Selected Publications

Redding LE, Cubas-Delgado F, Sammel MD, Smith G, Galligan DT, Levy MZ, Hennessy S: Antibiotic residues in milk from small dairy farms in rural Peru. Food Additives & Contaminants: Part A 31: 1001-08, 2014.

LoRe V III, Byrne DD, Newcomb CW, Carbonari DM, Nezamzadeh MS, Leidl KB, Herlim MX, Yang YX, Hennessy S, Kostman JR, Leonard MB, Localio R.: Prevalence of diagnosed chronic hepatitis b infection among U.S. Medicaid enrollees, 2000-2007. Annals of Epidemiology 24: 418-23, 2014

Redding LE, Cubas-Delgado F, Sammel MD, Smith G, Galligan DT, Levy MZ, Hennessy S: Comparison of two methods for collecting antibiotic use data on small dairy farms. Preventive Veterinary Medicine 1: 213-22, 2014

Flory JH, Small DS, Cassano PA, Brillon DJ, Mushlin AI, Hennessy S: Comparative effectiveness of oral diabetes drug combinations in reducing glycosylated hemoglobin. Journal of Comparative Effectiveness Research 3(1): 29-39, 2014.

Schelleman H, Han EX, Brensinger C, Quinney S, Bilker W, Flockhart D, Li L, Hennessy S: Pharmacoepidemiologic and in vitro evaluation of potential drug-drug interactions of sulfonylureas with fibrates and statins. British Journal of Clinical Pharmacology 78: 639-48, 2014.

Redding LE, Cubas-Delgado F, Sammel MD, Smith G, Galligan DT, Levy MZ, Hennessy S: The use of antibiotics on small dairy farms in rural Peru. Preventive Veterinary Medicine 113: 88-95, 2014.

Schelleman H, Bilker WB, Kimmel SE, Daniel GW, Newcomb C, Guevara JG, Cziraky MJ, Strom BL, Hennessy S: Methylphenidate and risk of serious cardiovascular events in adults. American Journal of Psychiatry 169: 178-85, 2012.

Mao JJ, Chung A, Benton A, Hill S, Ungar L, Leonard CE, Hennessy S, Holmes JH: Online discussion of drug side effects and discontinuation among breast cancer survivors. Pharmacoepidemiology and Drug Safety 22: 256-262, 2013.

Schelleman H, Bilker WB, Kimmel SE, Daniel GW, Newcome C, Guevara JP, Cziraky MJ, Strom BL, Hennessy S: Amphetamines, atomoxetine and the risk of serious cardiovascular events in adults. PLoS One 8: e52991, 2012.

Strom BL, Kimmel SE, Hennessy S: Textbook of Pharmacoepidemiology, 2nd edition. Pharmacoepidemiology. Sussex; John Wiley and Sons, 2013.

Leonard CE, Freeman CP, Newcomb C, Bilker WB, Kimmel SE, Strom BL, Hennessy S: Antipsychotics and the risks of sudden cardiac death and all-cause death: cohort studies in Medicaid and dually-eligible Medicaid-Medicare beneficiaries of five states. Journal of Clinical and Experimental Cardiology 10: 1-9, 2013

back to top
Last updated: 03/30/2015
The Trustees of the University of Pennsylvania