Alejandro Carabe-Fernandez

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Assistant Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Search Committee - Assistant Professor Tenure-Track, University of Pennsylvania Dept. of Radiation Oncology
Leader of CNS physics team, University Of Pennsylvania
Department: Radiation Oncology

Contact information
Hospital of the University of Pennsylvania
Department of Radiation Oncology
TRC 4 West, 4-324W
3400 Civic Center Boulevard
Phiadelphia, PA 19104
Office: (215) 614-1605
MPhys (Physics with Medical Technology)
University of Hull, 2000.
MSc (Medical Physics)
University of Glasgow, 2002.
Ph.D. (Radiobiology)
Imperial College, 2008.
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Description of Itmat Expertise

1) Radiotherapy treatment optimization based on radiobiological considerations in pediatric brain, or head and neck. I am specifically interested in craniopharyngioma.

2) development of proton arc therapy techniques that would allow to treat with higher doses to the tumor while keeping dose constrains to the normal tissue

3) Development of Tumor control probability/normal tissue complication probability models for radiotherapy radiobiological optimization

4) neutron boost in proton radiotherapy treatments to overcome radioresistance due to hypoxia

5) cyclotron based neutron beams by adding a berilium target to a proton line

Description of Research Expertise

Clinical and theoretical radiobiology
High-LET radiobiology and radiotherapy
Radiobiological Optimization
TCP/NTCP specific for high-LET radiations
Repair kinetics modeling
Proton Arc Thereapy

Selected Publications

Shampa Chatterjee, Ralph A. Pietrofesa, Kyewon Park, Jian-Qin Tao, Thais Sielecki, Alejandro Carabe-Fernandez, Abigail T. Berman, Constantinos Koumenis, and Melpo Christofidou-Solomidou : LGM2605 Reduces Space Radiation-Induced NLRP3 Inflammasome Activation and Damage in In Vitro Lung Vascular Networks Radiation Research Society 2018.

Ulmer W, Carabe-Fernandez A: Aspect of physical principles of the proton therapy with inclusion of nuclear interactions. Journal of Proton Therapy (ISSN 2469-5491) 3: 311, 2017.

N Delso , K Stutzer , M Kirk , S Huang , D Sanchez-Parcerisa , L Lin , G Freedman , J Metz , E Abel , A Carabe-Fernandez: Proton Modulated Arc Therapy Using Mono-Energetic Beams for the Treatment of Left-Sided Breast Cancer. Medical Physics 2017.

Sanchez-Parcerisa D, Kirk M, Fager M, Burgdorf B, Stowe M, Solberg T, Carabe A.: Range optimization for mono- and bi-energetic proton modulated arc therapy with pencil beam scanning. Phys Med Biol. 61(21): N565-N574, November 2016.

Sanchez-Parcerisa D, Cortés-Giraldo MA, Dolney D, Kondrla M, Fager M, Carabe A. : Analytical calculation of proton linear energy transfer in voxelized geometries including secondary protons. Phys Med Biol. 61(4): 1705-21, Feb 2016.

Alan Mitteer R, Wang Y, Shah J, Gordon S, Fager M, Butter PP, Jun Kim H, Guardiola-Salmeron C, Carabe-Fernandez A, Fan Y. : Proton beam radiation induces DNA damage and cell apoptosis in glioma stem cells through reactive oxygen species. Sci Rep. 5: 13961, Sep 2015 Notes: DOI: 10.1038/srep13961

Guardiola, C. and Quirion, D. and Pellegrini, G. and Fleta, C. and Esteban, S. and Cortés-Giraldo, M. A. and Gómez, F. and Solberg, T. and Carabe, A. and Lozano, M: Silicon-based three-dimensional microstructures for radiation dosimetry in hadrontherapy. Applied Physics Letters 107: 023505-1, Jul 2015.

Mayer R, Lin L, Fager M, Douglas D, McDonough J, Carabe A.: Proposed linear energy transfer areal detector for protons using radiochromic film. Rev Sci Instrum. 86(4): 044301, Apr 2015 Notes: DOI: 10.1063/1.4917418

Cortés-Giraldo MA, Carabe A.: A critical study of different Monte Carlo scoring methods of dose average linear-energy-transfer maps calculated in voxelized geometries irradiated with clinical proton beams. Phys Med Biol. 60(7): 2645-69, Apr 2015 Notes: Epub 2015 Mar 13.

Fager M, Toma-Dasu I, Kirk M, Dolney D, Diffenderfer ES, Vapiwala N, Carabe A.: Linear energy transfer painting with proton therapy: a means of reducing radiation doses with equivalent clinical effectiveness. Int J Radiat Oncol Biol Phys. 91(5): 1057-64, Apr 2015.

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Last updated: 11/10/2018
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