Charles P. O'Brien
Emeritus Professor of Psychiatry
Department: Psychiatry
Contact information
University of Pennsylvania
Treatment Research Center
3900 Chestnut Street
Philadelphia, PA 19104-6178
Treatment Research Center
3900 Chestnut Street
Philadelphia, PA 19104-6178
Office: 215-222-3200 ext.132
Fax: 215-386-6770
Fax: 215-386-6770
Email:
obrien@upenn.edu
obrien@upenn.edu
Education:
B.S.
Tulane University, 1960.
M.D.
Tulane Medical School, 1964.
M.S. ( Neurophysiology)
Physiology The Graduate School, Tulane University , 1964.
Ph.D. (Neurophysiology)
Physiology The Graduate School, Tulane University , 1966.
B.S.
Tulane University, 1960.
M.D.
Tulane Medical School, 1964.
M.S. ( Neurophysiology)
Physiology The Graduate School, Tulane University , 1964.
Ph.D. (Neurophysiology)
Physiology The Graduate School, Tulane University , 1966.
Post-Graduate Training
Medical House Office, Massachusetts General Hospital, 1964-1965.
Neurology and Psychiatry Resident, Tulane Medical School/Charity Hospital New Orleans, LA, 1965-1967.
Academic Registrar, National Hospital for Nervous Disease, Queen Square London, England, 1967-1968.
Psychiatry Resident, Hospital of the University of Pennsylvania, 1968-1969.
Permanent linkMedical House Office, Massachusetts General Hospital, 1964-1965.
Neurology and Psychiatry Resident, Tulane Medical School/Charity Hospital New Orleans, LA, 1965-1967.
Academic Registrar, National Hospital for Nervous Disease, Queen Square London, England, 1967-1968.
Psychiatry Resident, Hospital of the University of Pennsylvania, 1968-1969.
Description of Itmat Expertise
Dr. O'Brien is interested in the development of new medications for the treatment of addictive disorders.Selected Publications
Langleben, D.D., Busch, E.L., O’Brien, C.P., Elman, I. : Depot naltrexone decreases rewarding properties of sugar in patients with opioid dependence. Psychopharmacology 220(3): 559-64, 2012 Notes: . PMCID: PMC3302938.Anton, R.F., Litten, R.Z., Falk, D.E., Palumbo, J.M., Bartus, R.T., Robinson, R.L., Kranzler, H.R., Kosten, T.R., Meyer, R.E., O’Brien, C.P., Mann, K., Meulien, D. : The Alcohol Clinical Trials Initiative (ACTIVE): purpose and goals for assessing important and salient issues for medications development in alcohol use disorders. Drug Alcohol Depend 37(2): 402-411, 2012 Notes: PMCID: PC3242301.
Cheatle, M.D. and O’Brien, C.P. : Opioid therapy in patients with chronic non-cancer pain: Diagnostic and clinical challenges. Adv Psychoso Med 30: 61-91, 2011.
O’Brien, C.P., Gastfriend, D.R., Forman, R.F., Schweizer, E., and Pettinati, H.M. : Long-Term Opioid Blockade and Hedonic Response: Preliminary Data from Two Open-Label Extension Studies with Extended-Release Naltrexone. The American Journal on Addictions 20(2): 106-112, 2011.
O'Brien, C.P.: Addiction and Dependence in DSM-V. Addiction 106(5): 866-867, 2011.
O'Brien, C.P.: Neuroplasticity in addictive disorders. Dialogues Clin Neurosci 11: 350, 2009.
O’Brien, C.P., McLellan, A.T., Childress, A.R. and Woody, G.E: Penn/VA Center for Studies of Addiction. Neuropharmacology 56: 44, 2009.
O'Brien, C.P.: The CAGE Questionnaire for Detection of Alcoholism: A Remarkably Useful but Simple Tool JAMA 300(17): 2054, 2008.
O'Brien, C.P.: Evidence-based treatments of addiction. Philosophical Transactions of the Royal Society B 363: 3277, 2008.
O'Brien, C.P.: Clinical Crossroad: a 50-year-old woman addicted to heroin. JAMA 300(3): 314, 2008.