Elizabeth McDonald
Associate Professor of Radiology at the Hospital of the University of Pennsylvania
Active Radiologist, Penn Presbyterian Medical Center
Active Radiologist, Pennsylvania Hospital
Attending, Hospital of the University of Pennsylvania
Steering Committee, HUP Breast Cancer Clinical Steering Committee
Director Breast MRI, University of Pennsylvania
Affiliate Faculty, Penn Center for Cancer Care Innovation
Department: Radiology
Contact information
Hospital of University of Pennsylvania
Department of Radiology
1 Silverstein
3400 Spruce Street
Philadelphia, PA 19104
Department of Radiology
1 Silverstein
3400 Spruce Street
Philadelphia, PA 19104
Links
Komen Foundation Breast Cancer Research Blog
Lab website - Breast Cancer Translational Research group
Medical Advisor for Women’s Campaign International (WCI): WCI provides women around the world with the resources and tools they need to actively engage in public advocacy, market, and political processes.
Medical Advisor for The Chrysalis Initiative: Erasing the line of inequality in breast cancer care
Komen Foundation Breast Cancer Research Blog
Lab website - Breast Cancer Translational Research group
Medical Advisor for Women’s Campaign International (WCI): WCI provides women around the world with the resources and tools they need to actively engage in public advocacy, market, and political processes.
Medical Advisor for The Chrysalis Initiative: Erasing the line of inequality in breast cancer care
Education:
BA (Biochemistry (magna cum laude))
Harvard University, 1995.
PhD (Molecular Neuroscience)
Mayo Graduate School of Medicine, 2003.
MD (Doctor of Medicine)
Mayo Medical School, 2003.
BA (Biochemistry (magna cum laude))
Harvard University, 1995.
PhD (Molecular Neuroscience)
Mayo Graduate School of Medicine, 2003.
MD (Doctor of Medicine)
Mayo Medical School, 2003.
Post-Graduate Training
Internship, Internal Medicine, Mayo School of Graduate Medical Education, 2003-2004.
Residency, Radiology, Mayo School of Graduate Medical Education, 2004-2008.
Thoracic Radiology Fellowship, Mayo School of Graduate Medical Education, 2008-2009.
Breast Imaging Fellowship, University of Washington, 2013-2013.
Certificate in Translational Research, Institute for Translational Medicine and Therapeutics, University of Pennsylvania, 2016-2018.
Permanent linkInternship, Internal Medicine, Mayo School of Graduate Medical Education, 2003-2004.
Residency, Radiology, Mayo School of Graduate Medical Education, 2004-2008.
Thoracic Radiology Fellowship, Mayo School of Graduate Medical Education, 2008-2009.
Breast Imaging Fellowship, University of Washington, 2013-2013.
Certificate in Translational Research, Institute for Translational Medicine and Therapeutics, University of Pennsylvania, 2016-2018.
Description of Itmat Expertise
My interests involve translational research with the aim of early detection of breast cancer and individualized treatment targeting tumor specific gene expression while minimizing whole body toxicity.Selected Publications
McDonald ES, Pantel AR, Shah PD, Farwell MD, Clark AS, Doot RK, Pryma DA, Carlin SD.: In vivo visualization of PARP inhibitor pharmacodynamics. JCI Insight 6: Apr 22;6(8):e146592. Apr 2021.Lee, HS, Schwarz, SW, Schubert, EK, Chen, DL, Doot, RK, Makvandi, M, Lin, LL, McDonald, ES, Mankoff, DA, Mach, RH.: The Development of 18F Fluorthanatrace: A PET Radiotracer for Imaging Poly (ADP-Ribose) Polymerase-1. Radiol Imaging Cancer Page: Jan;4(1):e210070. 2022.
McDonald ES, Romanoff J, Rahbar H, Kitsch AE, Harvey SM, Whisenant JG, Yankeelov TE, Moy L, DeMartini WB, Dogan BE, Yang WT, Wang LC, Joe BN, Wilmes LJ, Hylton NM, Oh KY, Tudorica LA, Neal CH, Malyarenko DI, Comstock CE, Schnall MD, Chenevert TL, Partridge SC.: Mean Apparent Diffusion Coefficient Is a Sufficient Conventional Diffusion-weighted MRI Metric to Improve Breast MRI Diagnostic Performance: Results from the ECOG-ACRIN Cancer Research Group A6702 Diffusion Imaging Trial. Radiology 298: 60-70, Jan 2021.
McDonald, ES, Doot, RK, Young, AJ, Shubert, ES, Tchou, J, Pyrma, DA, Farwell, MD, Nayak, A, Ziober, A, Feldman, MD, DeMichele, A, Clark, AS, Shah, PD, Lee, H, Carlin, SD, Mach, RH, Mankoff, DA: Breast Cancer 18F-ISO-1 Uptake as a Marker of Proliferation Status Journal of Nuclear Medicine 61(5): 665-670, May 2020 Notes: doi: 10.2967/jnumed.119.232363.
Whisenant JG, Romanoff J, Rahbar H, Kitsch AE, Harvey SM, Moy L, DeMartini WB, Dogan BE, Yang WT, Wang LC, Joe BN, Wilmes LJ, Hylton NM, Oh KY, Tudorica LA, Neal CH, Malyarenko DI, McDonald ES, Comstock CE, Yankeelov TE, Chenevert TL, Partridge SC.: Factors Affecting Image Quality and Lesion Evaluability in Breast Diffusion-weighted MRI: Observations from the ECOG-ACRIN Cancer Research Group Multisite Trial (A6702). J Breast Imaging 3: 44-56, Dec 2020.
Elmi A, Conant EF, Kozlov A, Young AJ, Long Q, Doot RK, McDonald ES: Preoperative breast MR imaging in newly diagnosed breast cancer: Comparison of outcomes based on mammographic modality, breast density and breast parenchymal enhancement. Clin Imaging 70: 18-24, Feb 2021 Notes: doi: 10.1016/j.clinimag.2020.10.021. Epub 2020 Oct 13.
Li W, Newitt D, Gibbs J, Wilmes L, Jones E, Arasu V, Strand F, Onishi, N, Kornack J, Joe BN, Price E, Ojeda-Fournier Haydee, Zamora KW, Woodard SA, Wolverton D, Brandt, KR, McDonald ES, Rosen m, Kontos D, Rahbar H, Crane E, Pulin S, Niell B, Drukteinis J, Newell MS, Cohen M, Giurescu M, Berman E, Lehman C, Partridge, SC, Fitzpatrick K, Borders M, Yang,W, Basak D, Goudreau S, Berry D, DeMichele, A, Yau C, Hylton NM, Esserman, L. : Predicting breast cancer response to neoadjuvant treatment using multi-feature MRI: results from the I-SPY 2 TRIAL. npj Breast Cancer 6: 63, Nov 2020
McDonald, ES, Doot, RK, Pantel, AR, Farwell, MD, Mach, RH, Maxwell, KN, Mankoff, DA: Positron Emission Tomography Imaging of Poly-(Adenosine Diphosphate-Ribose) Polymerase 1 Expression in Breast Cancer: A Nonrandomized Clinical Trial. JAMA Oncology 6(6): 921-923, Jun 2020 Notes:
Susan P. Weinstein, MD, Mitchell D. Schnall, MD, PhD, Claire M. Cirelli, Arijitt Borthakur, MBA, PhD, Elizabeth McDonald, MD, PhD, Emily F. Conant, MD: Abbreviated Breast MR for Supplemental Screening of Women with Dense Breasts and Average Risk. Journal of Clinical Oncology 38(33): 3874-3882, Nov 2020 Notes: DOI: 10.1200/JCO.19.02198.
Chong A, Weinstein SP, McDonald ES, Conant EF: Digital Breast Tomosynthesis: Concepts and Clinical Practice. Radiology 292(1): 1-14, Jul 2019 Notes: doi: 10.1148/radiol.2019180760.
Elmi A, McDonald ES, Mankoff D.: Imaging Tumor Proliferation in Breast Cancer: Current Update on Predictive Imaging Biomarkers. PET Clin 13(3): 445-457, July 2018 Notes: doi: 10.1016/j.cpet.2018.02.007.
Conant, EF, Zuckerman, S, McDonald, ES, Weinstein, SP, Korhonen, K, Synnestvedt, M, Schnall, M, Hubbard, RA: Five Consecutive Years of Screening with Digital Breast Tomosynthesis: Outcomes by Screening Year and Round Radiology 295(2): 285-293, May 2020 Notes: doi: 10.1148/radiol.2020191751.
Chitalia R, Rowland J, McDonald ES, Pantalone L, Cohen EA, Gastounioti A, Feldman M, Schnall M, Conant E, Kontos D.: Imaging phenotypes of breast cancer heterogeneity in pre-operative breast Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) scans predict 10-year recurrence. Clinical Cancer Research 26(4): 862-869, Feb 2020 Notes: doi: 10.1158/1078-0432.
Rahbar H, Zhang Z, Chenevert TL, Romanoff J, Kitsch AE, Hanna LG, Harvey SM, Moy L, DeMartini WB, Dogan B, Yang WT, Wang LC, Joe BN, Oh KY, Neal CH, McDonald ES, Schnall MD, Lehman CD, Comstock CE, Partridge SC: Utility of Diffusion-weighted Imaging to Decrease Unnecessary Biopsies Prompted by Breast MRI: A Trial of the ECOG-ACRIN Cancer Research Group (A6702). Clinical Cancer Research 25(6): 1756-1765, Mar 2019 Notes: doi: 10.1158/1078-0432.
McDonald ES, Ulaner GA.: Uses and Opportunities for Molecular Imaging in Patients with Breast Cancer. PET Clin. 2018 Jul;13(3):xi-xii. 13(3): xi-xii, Jul 2018 Notes: doi: 10.1016/j.cpet.2018.05.001.
Le, TT. McDonald, ES, Isaac, G., Rosen, M. Dougherty, L.: Effect of Contrast Dose on Diagnostic Performance in DCE-MR Breast Imaging. Journal of Applied Clinical Medical Physics 21(11): 188-194, November 2020 Notes: doi: 10.1002/acm2.13010.
Korhonen KE, Conant EF, Cohen EA, Synnestvedt M, McDonald ES, Weinstein SP: Breast Cancer Conspicuity on Simultaneously Acquired Digital Mammographic Images versus Digital Breast Tomosynthesis Images. Radiology 292(1): 69-76, Jul 2019 Notes: doi: 10.1148/radiol.2019182027.
Mirzabeigi MN, Rhemtulla IA, Mcdonald ES, Sataloff DM, Kovach SJ, Wu LC, Serletti JM, Kanchwala S.: Locoregional Cancer Recurrence after Breast Reconstruction: Detection, Management, and Secondary Reconstructive Strategies. Plastic and Reconstructive Surgery 143(5): 1322-1330, May 2019 Notes: doi: 10.1097/PRS.0000000000005522.
Derakhshan JJ, McDonald ES, Siegelman ES, Schnall MD, Wehrli FW: Characterizing and eliminating errors in enhancement and subtraction artifacts in dynamic contrast-enhanced breast MRI: Chemical shift artifact of the third kind. Magnetic Resonance in Medicine 79(4): 2277-2289, Apr 2018 Notes: doi: 10.1002/mrm.26879.
So A, De La Cruz LM, Williams AD, Bahng J, Liao G, McDonald ES, Fisher CS, Czerniecki BJ, Sataloff D, Tchou J: The impact of preoperative magnetic resonance imaging and lumpectomy cavity shavings on re-excision rate in pure ductal carcinoma in situ-A single institution's experience. Journal of Surgical Oncology 117(4): 558-566, Mar 2018 Notes: doi: 10.1002/jso.24890.
Hsu JC, Naha PC, Lau KC, Chhour P, Hastings R, Moon BF, Stein JM, Witschey WRT, McDonald ES, Maidment ADA, Cormode DP: An all-in-one nanoparticle (AION) contrast agent for breast cancer screening with DEM-CT-MRI-NIRF imaging. Nanoscale 10(36): 17236-17248, Sept 2018 Notes: doi: 10.1039/c8nr03741h.
Chudgar, AV, Conant, EF, Weinstein, SP, Keller, BM, Synnestvedt, M, Yamartino, P, McDonald, ES: Assessment of disease extent on contrast-enhanced MRI in breast cancer detected at digital breast tomosynthesis versus digital mammography alone. Clinical Radiology 72(7): 573-579, Jul 2017 Notes: doi: 10.1016/j.crad.2017.02.013.
Zuckerman SP, Maidment ADA, Weinstein SP, McDonald ES, Conant EF: Imaging with synthesized 2D mammography: differences, advantages, and pitfalls compared with digital mammography. American Journal of Roentgenology 209(1): 222-229, Jul 2017 Notes: doi: 10.2214/AJR.16.17476.
McDonald ES, McCarthy AM, Weinstein SP, Schnall MD, Conant EF: BI-RADS category 3 comparison: probably benign category after recall from screening before and after implementation of digital breast tomosynthesis. Radiology 285(3): 778-787, Dec 2017 Notes: doi: 10.1148/radiol.2017162837.
McDonald ES, Mankoff D, Makvandi M, Chu W, Chu Y, Mach RH, Zeng C: Sigma-2 ligands and PARP inhibitors synergistically trigger cell death cancer cells. Biochemical and Biophysical Research Communications 486(3): 788-795, May 2017 Notes: DOI: 10.1016/j.bbrc.2017.03.122.
Zeng C, McDonald ES, Mach RH: Molecular probes for imaging the sigma-2 receptor: In vitro and in vivo imaging studies. Handbook of Experimental Pharmacology 244: 309-330, Feb 2017 Notes: doi: 10.1007/164_2016_96.
Conant EF, Keller BM, Pantalone L, Gastounioti A, McDonald ES, Kontos D: Agreement between breast percentage density estimations from standard-dose versus synthetic digital mammograms: Results from a large screening cohort using automated measures. Radiology 283(3): 673-680, June 2017 Notes: doi: 10.1148/radiol.2016161286.
Cruz, L, McDonald, ES, Mick, R, Czerneicki, B: Anti-HER2 Th1 Response is Superior to Breast MRI in Response to Neoadjuvant Chemotherapy in Patients with HER2 Positive Breast Cancer. Annals of Surgical Oncology 24(4): 1057-1063, Apr 2017 Notes: doi: 10.1245/s10434-016-5651-z.
Pertuz S, McDonald ES, Weinstein SP, Conant EC, Kontos D: Fully-automated quantitative estimation of volumetric breast density from digital breast tomosynthesis images: Preliminary results and comparison with digital mammography and magnetic resonance imaging. Radiology 279(1): 65-74, Apr 2016 Notes: DOI:10.1148/radiol.2015150277.
Mitsumori LM, McDonald ES, Neligan PC, Maki JH: Peripheral Magnetic Resonance Lymphangiography: Techniques and Applications. Techniques in Vascular and Interventional Radiology 19(4): 262-272, Dec 2016 Notes: DOI: 10.1053/j.tvir.2016.10.007.
Korhonen KE, Weinstein SP, McDonald ES, Conant EF: Strategies to increase cancer detection: Review of true-positive and false-negative results at digital breast tomosynthesis screening. Radiographics 36(7): 1954-1965, Nov-Dec 2016 Notes: DOI: 10.1148/rg.2016160049.
Naha PC, Lau KC, Hsu JC, Hajfathalian M, Mian S, Chhour P, Uppuluri L, McDonald ES, Maidment AD, Cormode DP: Gold silver alloy nanoparticles (GSAN): an imaging probe for breast cancer screening with dual-energy mammography or computed tomography. Nanoscale 8(28): 13740-13754, Jul 2016 Notes: DOI: 10.1039/c6nr02618d.
Makvandi, M, Xu, K, Lieberman, BP, Anderson, R, Effron, SS, Winters, H, Zeng, C, McDonald, ES, Pryma, DA, Greenberg, RA, Mach, RH: A radiotracer strategy to quantify PARP-1 expression in vivo provides a biomarker that can enable patient selection for PARP inhibitor therapy. Cancer Research 76(15): 4516-4524, Aug 2016 Notes: DOI:10.1158/0008-5472.CAN-16-0416.
Zuckerman S,Conant EF,Keller B,Weinstein S,McDonald ES.: Implementation of synthesized 2D mammography in a population-based digital breast tomosynthesis screening program. Radiology 28(1): 730-736, Dec 2016 Notes: DOI: 10.1148/radiol.2016160366 Nominated for Scientific Paper of the Year AuntMinnie.com.
McDonald ES, Mankoff DA, Mach RH: Novel strategies for breast cancer imaging: new imaging agents to guide treatment. Journal of Nuclear Medicine 57: 69S-74S, Feb 2016 Notes: doi: 10.2967/jnumed.115.157925.
McDonald ES, Hammersley JA, Chou SS, Rahbar H, Scheel JR, Lee CI, Liu CL, Lehman CD, Partridge SC: Performance of DWI as a Rapid Unenhanced Technique for Detecting Mammographically Occult Breast Cancer in Elevated-Risk Women with Dense Breasts. American Journal of Roentgenology 207(1): 205-216, Jul 2016 Notes: DOI:10.2214/AJR.15.15873.
Mirzabeigi MN, McDonald ES, Chu MW, Fischer JP, Basta M, Kovach S, Wu LC, Serletti J, Kanchwala S: Operative management of locoregional cancer recurrence following post-mastectomy breast reconstruction-indications and outcomes. American Society for Reconstructive Microsurgery 2016 Notes: Oral Presentation.
McDonald ES, Oustimov A, Weinstein SP, Synnestvedt M, Schnall MD, Conant EF: Effectiveness of digital breast tomosynthesis compared with digital mammography: Outcomes analysis from 3 years of breast cancer screening. JAMA Oncology 2(6): 737-743, Jun 2016 Notes: DOI: 10.1001/jamaoncol.2015.5536.
Chen L, Ray S, Keller BM, Pertuz S, McDonald ES, Conant EF, Kontos D: The Impact of acquisition dose on quantitative breast density estimation with digital mammography: Results from ACRIN PA 4006. Radiology 280(3): 693-700, Sep 2016 Notes: DOI: 10.1148/radiol.2016151749.
McDonald ES, Clark A, Tchou J, Zhang, P, Freedman, G.: Clinical diagnosis and management of breast cancer. Journal of Nuclear Medicine 57(Suppl 1): 9S-16S, Feb 2016 Notes: DOI: 10.2967/jnumed.115.157834.
McDonald ES, McCarthy AM, Akhtar A, Synnestvedt A, Schnall M, Conant EF: Baseline screening mammography: Performance of full field digital versus digital breast tomosynthesis. American Journal of Roentgenology 205(5): 1143-1148, Nov 2015 Notes: DOI: 10.2214/AJR.15.14406.
Rahbar, H, McDonald, ES, Lee, JM, Partridge, SC, Lee, CI.: How Can Advanced Imaging Be Used to Mitigate Potential Breast Cancer Overdiagnosis? Academic Radiology 23(6): 768-773, Jun 2016 Notes: DOI: 10.1016/j.acra.2016.02.008.
Makvandi M, Tilahun ED, Lieberman BP, Anderson RC, Zeng C, Xu K, Hou C, McDonald ES, Pryma DA,Mach RH: The sigma-2 receptor as a therapeutic target for drug delivery in triple negative breast cancer. Biochemical and Biophysical Research Communications 467(4): 1070-1075, Nov 2015 Notes: DOI: 10.1016/j.bbrc.2015.09.157.
Mitsumori LM, McDonald ES, Wilson GJ, Neligan PC, Minoshima S, Maki JH: MR Lymphangiography: How I do it. Journal of Magnetic Resonance Imaging 42(6): 1465-1477, Dec 2015 Notes: DOI: 10.1002/jmri.24887.
McDonald ES, Schopp JG, Peacock S, DeMartini WB, Rahbar H, Lehman CD, Partridge SC: Diffusion-weighted MRI: association between patient characteristics and apparent diffusion coefficients of normal breast fibroglandular tissue at 3 T. American Journal of Roentgenology 202(5): W496-502, May 2014 Notes: DOI: 10.2214/AJR.13.11159.
Clark AS, McDonald E, Lynch MC, Mankoff D: Using nuclear medicine imaging in clinical practice: update on PET to guide treatment of patients with metastatic breast cancer. Oncology 28(5): 424-430, May 2014.
Doot RK, McDonald ES, Mankoff DA: Role of PET quantitation in the monitoring of cancer response to treatment: review of approaches and human clinical trials. Clinical and Translational Imaging 2(4): 295-303, Aug 2014 Notes: DOI: 10.1007/s40336-014-0071-1.
Partridge SC, McDonald ES: Diffusion weighted magnetic resonance imaging of the breast: protocol optimization, interpretation, and clinical applications. Magnetic Resonance Imaging Clinics of North America 21(3): 601-624, Aug 2013 Notes: doi: 10.1016/j.mric.2013.04.007.
McDonald ES, Conant EF: Breast MRI 4th Edition, Radiology Secrets Plus. Radiology Secrets. Torigian Drew, Ramchandani P (eds.). 2016.