Yanqing Anna Gong

faculty photo
Research Assistant Professor of Medicine
Department: Medicine

Contact information
Perelman School of Medicine at The University of Pennsylvania
Division of Translational Medicine and Human Genetics
Smilow Center for Translational Research, Room 11-142
3400 Civic Center Blvd.
Philadelphia, PA 19104
Pennsylvania, PA 19104
Office: 215-746-3510
Fax: 215-573-8606
Education:
M.S. (Medicinal Chemistry)
China Pharmaceutical University, 2000.
PhD (Pharmacology)
China Pharmaceutical University, 2003.
postdoc
Department of Anatomy, Case Western Reserve University, 2005.
postdoc
Department of Molecular Cardiology, Cleveland Clinic, 2008.
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Description of Itmat Expertise

Protease
stem cell
vessel formation
Endothelial cell plasticity
tissue repair

Description of Research Expertise

My research focuses on deciphering the key molecular mechanism that regulates vessel formation and tissue repair. My lab uses a multidisciplinary approach combining cell and molecular biology, genetics, and animal models to investigate: 1. The molecular mechanisms by which proteases regulate stem cell function during tissue repair and regeneration; 2. The regulatory mechanism underlying new vessel formation in normal development and disease; 3 Endothelial plasticity in ischemic microenvironment that leads to the abnormal neovascularization in ischemic heart disease.

Selected Publications

Wang Q, He Z, Huang M, Liu T, Xu H, Ma P, Zhang L, Zamvil SS, Hidalgo J, Zhang Z, O’Rourke DM, Dahmane N, Brem S, Gong Y, & Fan Y: Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α Nature Comm. 9(559), Feb 2018.

Wang Y, Xu H, Liu T, Huang M, Butter P, Li C, Zhang L, Kao G, Gong Y, Maity A, Koumenis C, & Fan Y: Temporal DNA-PK activation drives genomic instability and therapy resistance in glioma stem cells. JCI Insight. 3(3): e98096, Feb 2018.

Tao L., Yang J., Cao F., Xie H., Zhang M., Gong Y.*, Zhang C.* : Mogroside IIIE, A novel anti-fibrotic compound, reduces pulmonary fibrosis through Toll like receptor 4 pathways. J Pharmacol. Exp. Ther. 361(2), 268-279 2017 *co-senior author Notes: Epub 2017 Mar 9. doi: 10.1124/jpet.116.239137.

Huang M., Liu T., Ma P., Mitteer A., Cai, P., Li C., Zhang L., Zhao B., Gong Y. Koumenis, C., Fan Y: c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma. J. Clin. Invest. 126 (5): 1801-14, 2016.

Gong Y*, Zhao Y, Li Y, Fan Y, Hoover-Plow J : Plasminogen regulates cardiac repair after myocardial infarction through its noncanonical function in stem cell homing to the infarcted heart. J Am Coll Cardiol 63(25): 2862-2872, Jul 2014 *Corresponding author.

Huang M, Gong Y, Grondosky J, Hoover-Plow J: Lp(a)/apo(a) modulate MMP-9 activation and neutrophil cytokines in vivo in inflammation to regulate leukocyte recruitment. Am J Pathol 184(5): 1503-1507, May 2014.

Fan Y, Potdar AA, Gong Y, Eswarappa SM, Donnola S, Lathia JD, Hambardzumyan D, Rich JN, Fox PL : Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1α accumulation. Nat Cell Biol 16(5): 445-456, May 2014.

Fan Y, Arif A, Gong Y, Jia J, Eswarappa SM, Willard B, Horowitz A, Graham LM, Penn MS, Fox PL. : Stimulus-dependent phosphorylation of profilin-1 in angiogenesis. Nat Cell Biol 14(10): 1046-56, October 2012.

Gong Y*, Fan Y, Hoover-Plow J: Plasminogen regulates stromal cell-derived factor-1/CXCR4-mediated hematopoietic stem cell mobilization by activation of matrix metalloproteinase-9. Arterioscler Thromb Vasc Biol 31(9): 2035-43, September 2011 *Corresponding author.

Gong Y, Hart E, Shchurin A, Hoover-Plow J: Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice. J Clin Invest 118(9): 3012-24, September 2008.

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Last updated: 11/29/2018
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