Pedro Gonzalez-Alegre

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Associate Professor of Neurology at the Pennsylvania Hospital
Co-Director, Clinical Programs, Raymond G. Perelman Center for Molecular & Cellular Therapy Children Hospital of Philadelphia
Director, Neurogenetics Program Department of Neurology The University of Pennsylvania
Director, Huntington's Disease Center of Excellence Department of Neurology The University of Pennsylvania
Co-Director, Division of Movement Disorders Department of Neurology The University of Pennsylvania
Department: Neurology

Contact information
University of Pennsylvania
Department of Neurology
800 Spruce Street
Philadelphia, PA 19107
Education:
MD
University of Malaga Medical School, Málaga (Spain), 1996.
PhD (Neuroscience)
University of Malaga Medical School, Málaga (Spain), 2009.
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Description of Itmat Expertise

My main interest is to develop new molecular treatment approaches in the laboratory and bring them all the way to early phase human trials. I am specifically interested on neurodegenerative and inherited neurological diseases. Current projects include development of gene silencing for dystonia (currently proof of concept studies in rodents) and design of early phase clinical trials for Batten's disease, Huntington's disease and SCA1.

Selected Publications

Aguilo Francesca, Zakirova Zuchra, Nolan Katie, Wagner Ryan, Sharma Rajal, Hogan Megan, Wei Chengguo, Sun Yifei, Walsh Martin J, Kelley Kevin, Zhang Weijia, Ozelius Laurie J, Gonzalez-Alegre Pedro, Zwaka Thomas P, Ehrlich Michelle E: THAP1: Role in Mouse Embryonic Stem Cell Survival and Differentiation. Stem cell reports 9(1): 92-107, Jul 2017.

Reichert Sara Chadwick, Gonzalez-Alegre Pedro, Scharer Gunter H: Biallelic TOR1A variants in an infant with severe arthrogryposis. Neurology. Genetics 3(3): e154, Jun 2017.

Lee Jessica K, Ding Yue, Conrad Amy L, Cattaneo Elena, Epping Eric, Mathews Kathy, Gonzalez-Alegre Pedro, Cahill Larry, Magnotta Vincent, Schlaggar Bradley L, Perlmutter Joel S, Kim Regina E Y, Dawson Jeffrey D, Nopoulos Peg: Sex-specific effects of the Huntington gene on normal neurodevelopment. Journal of neuroscience research 95(1-2): 398-408, Jan 2017.

Keiser Megan S, Monteys Alejandro Mas, Corbau Romuald, Gonzalez-Alegre Pedro, Davidson Beverly L: RNAi prevents and reverses phenotypes induced by mutant human ataxin-1. Annals of neurology 80(5): 754-765, Nov 2016.

Beauvais Genevieve, Bode Nicole M, Watson Jaime L, Wen Hsiang, Glenn Kevin A, Kawano Hiroyuki, Harata N Charles, Ehrlich Michelle E, Gonzalez-Alegre Pedro: Disruption of Protein Processing in the Endoplasmic Reticulum of DYT1 Knock-in Mice Implicates Novel Pathways in Dystonia Pathogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience 36(40): 10245-10256, Oct 2016.

García-Casares Natalia, García-Arnés Juan A, Rioja Jose, Ariza María José, Gutiérrez Antonio, Alfaro Francisco, Nabrozidis Alejandro, González-Alegre Pedro, González-Santos Pedro: Alzheimer's like brain changes correlate with low adiponectin plasma levels in type 2 diabetic patients. Journal of diabetes and its complications 30(2): 281-6, Mar 2016.

Klionsky et al.: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12(1): 1-222, 2016.

Keiser Megan S, Kordower Jeffrey H, Gonzalez-Alegre Pedro, Davidson Beverly L: Broad distribution of ataxin 1 silencing in rhesus cerebella for spinocerebellar ataxia type 1 therapy. Brain : a journal of neurology 138(Pt 12): 3555-66, Dec 2015.

Ruiz Marta, Perez-Garcia Georgina, Ortiz-Virumbrales Maitane, Méneret Aurelie, Morant Andrika, Kottwitz Jessica, Fuchs Tania, Bonet Justine, Gonzalez-Alegre Pedro, Hof Patrick R, Ozelius Laurie J, Ehrlich Michelle E: Abnormalities of motor function, transcription and cerebellar structure in mouse models of THAP1 dystonia. Human molecular genetics 24(25): 7159-70, Dec 2015.

Edwards Cory, Leira Enrique C, Gonzalez-Alegre Pedro: Residency training: a failed lumbar puncture is more about obesity than lack of ability. Neurology 84(10): e69-72, Mar 2015.

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Last updated: 12/06/2017
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