Gary D. Wu

faculty photo
Ferdinand G. Weisbrod Professor in Gastroenterology
Associate Director NIH Training Grant in Gastrointestinal Sciences, Perelman School of Medicine, University of Pennsylvania (T32-DK07066)
Director, Human-Microbial Analytic and Repository Core Facility, NIH Center for Molecular Studies in Digestive and Liver Diseases (P30 DK50306), Perelman School of Medicine, University of Pennsylvania
Co-Director, Penn-CHOP Center for Digestive, Liver and Pancreatic Medicine, Perelman School of Medicine, University of Pennsylvania and the Children's Hospital of Philadelphia
Ferdinand G. Weisbrod Professor in Gastroenterology, University of Pennsylvania School of Medicine
Co-Director, Penn-CHOP Microbiome Program , Perelman School of Medicine, University of Pennsylvania and the Children's Hospital of Philadelphia
Director, Microbial Culture and Metabolomics Core for the PennCHOP Microbiome Program, Perelman School of Medicine, University of Pennsylvania and the Children's Hospital of Philadelphia
Director, Penn Center for Nutritional Science and Medicine, Pereleman School of Medicine, University of Pennsylvania
Co-Director, Center for Molecular Studies in Digestive and Liver Disease (P30 DK50306), Perelman School of Medicine, University of Pennsylvania
Department: Medicine
Graduate Group Affiliations

Contact information
421 Curie Boulevard
915 Biomedical Research Building II/III
Philadelphia, PA 19104
Office: 215-898-0158
Fax: 215-573-2024
Education:
A.B. (Chemistry)
Cornell University, 1980.
M.D.
Northwestern University Medical School, 1986.
M.A. (Honorary)
University of Pennsylvania, 2002.
Post-Graduate Training
Intern, University of Minnesota Hospital, 1986-1987.
Resident, University of Minnesota Hospital, 1987-1989.
Fellow (Gastroenterology), University of Michigan, Ann Arbor, 1989-1992.
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Description of Research Expertise

Research Program
Diet, the Gut Microbiome, and Host Metabolism

Program Summary
Dr. Wu is the Ferdinand G. Weisbrod Professor in Gastroenterology at the Perelman School of Medicine at the University of Pennsylvania where he is the Co-Director of the Center for Molecular Studies in Digestive and Liver Disease. He was the inaugural Director and Chair of the Scientific Advisory Board for the American Gastroenterological Association Center for Gut Microbiome Research and Education and is an elected member of both the American Society for Clinical Investigation and the Association of American Physicians. He is the Co-Director of the PennCHOP Microbiome Program, a campus-wide initiative to accelerate research in the microbiome across the entire university campus. The current research programs in the Wu laboratory focus on the mutualistic interactions between the gut microbiota and the host with a particular focus on metabolism. Growing evidence suggests that diet impacts upon both the structure and function of the gut microbiota that, in turn, influences the host in fundamental ways. Current areas of investigation include the effect of diet on the composition of the gut microbiota and its subsequence effect on host metabolism related to nitrogen balance as well as its impact on metabolic pathways in the intestinal epithelium, principally fatty acid oxidation. In 2018, Dr. Wu was appointed as the Director of the Penn Center for Nutritional Sciences and Medicine (PenNSAM), a joint collaboration between the Penn School of Medicine, the School of Nursing, and the Children’s Hospital of Philadelphia. PenNSAM focuses on integrating human clinical metadata, traditional dietary assessments, and nutritional biomarkers with the latest high throughput molecular profiling technologies together with advanced biostatistical and computational tools in a transformational approach to improve human health and ameliorate disease through diet and nutrition.

Lab personnel:
Aaron Hecht, MD, PhD
Lillian Chau, MS
Elliot Friedman, PhD
Dylan Curry, PhD
Johanna Lemons, PhD
Bryce Perler, MD
Lindsey Herman, BS

Description of Itmat Expertise

Impact of diet on the structure and function of the gut microbiome and its resultant effects on host metabolism. Current areas of interest include host nitrogen balance as well as immune and intestinal epithelial function.

Selected Publications

Chassaing B, Compher C, Bonhomme B, Liu Q, Tian Y, Walters W, Nessel L, Delaroque C, Hao F, Gershuni V, Chau L, Ni J, Bewtra M, Albenberg L, Bretin A, McKeever L, Ley RE, Patterson AD, Wu GD, Gewirtz AT, Lewis JD.: Randomized controlled-feeding study of dietary emulsifier carboxymethylcellulose reveals detrimental impacts on the gut microbiota and metabolome. Gastroenterology Nov 2021.

Chatterji P, Williams PA, Whelan KA, Samper FC, Andres SF, Simon LA, Parham LR, Mizuno R, Lundsmith ET, Lee DS, Liang S, Wijeratne HS, Marti S, Chau L, Giroux V, Wilkins BJ, Wu GD, Shah P, Tartaglia GG, Hamilton KE.: Posttranscriptional regulation of colonic epithelial repair by RNA binding protein IMP1/IGF2BP1. EMBO Rep 22: e47074, Aug 2021.

Saiman Y, Shen TD, Lund PJ, Gershuni VM, Jang C, Patel S, Jung S, Furth EE, Friedman ES, Chau L, Garcia BA, Wu GD.: Global Microbiota-Dependent Histone Acetylation Patterns Are Irreversible and Independent of Short Chain Fatty Acids. Hepatology Jul 2021.

Roy Paladhi U, Harb AH, Daniel SG, Dawwas GK, Schnellinger EM, Wollack C, Aberra FN, Bewtra M, Green JA, Klaproth JA, Lichtenstein GR, Saxena A, Berera S, Buchner A, Mehta SJ, Osterman MT, Rashid F, Tomov V, Caldera F, Sumona S, Mahadevan U, Roy A, Nessel L, Wu GD, Bittinger K, Lewis JD.: The Impact of Introducing Patient-Reported Inflammatory Bowel Disease Symptoms via Electronic Survey on Clinic Visit Length, Patient and Provider Satisfaction, and the Environment Microbiome. Inflamm Bowel Dis 27: 746-750, Apr 2021.

Weiss SL, Bittinger K, Lee JJ, Friedman ES, Mattei LM, Graham K, Zhang D, Bush J, Balamuth F, McGowan FX Jr, Bushman FD, Baldassano RN, Wu GD, Wallace DC, Collman RG.: Decreased Intestinal Microbiome Diversity in Pediatric Sepsis: A Conceptual Framework for Intestinal Dysbiosis to Influence Immunometabolic Function. Crit Care Explor 3: e0360, Mar 2021.

Tanes C, Bittinger K, Gao Y, Friedman ES, Nessel L, Paladhi UR, Chau L, Panfen E, Fischbach MA, Braun J, Xavier RJ, Clish CB, Li H, Bushman FD, Lewis JD, Wu GD.: Role of dietary fiber in the recovery of the human gut microbiome and its metabolome. Cell Host Microbe 29: 394-407, Mar 2021.

Gershuni V, Li Y, Elovitz M, Li H, Wu GD, Compher CW.: Maternal gut microbiota reflecting poor diet quality is associated with spontaneous preterm birth in a prospective cohort study. Am J Clin Nutr 113: 602-611, Mar 2021.

Smith SA, Ogawa SA, Chau L, Whelan KA, Hamilton KE, Chen J, Tan L, Chen EZ, Keilbaugh S, Fogt F, Bewtra M, Braun J, Xavier RJ, Clish CB, Slaff B, Weljie AM, Bushman FD, Lewis JD, Li H, Master SR, Bennett MJ, Nakagawa H, Wu GD.: Mitochondrial dysfunction in inflammatory bowel disease alters intestinal epithelial metabolism of hepatic acylcarnitines. J Clin Invest 131: e133371, Jan 2021.

Shen TD, Daniel SG, Patel S, Kaplan E, Phung L, Lemelle-Thomas K, Chau L, Herman L, Trisolini C, Stonelake A, Toal E, Khungar V, Bittinger K, Reddy KR, Wu GD.: The Mucosally-Adherent Rectal Microbiota Contains Features Unique to Alcohol-Related Cirrhosis. Gut Microbes 2021.

Kelly CR, Yen EF, Grinspan AM, Kahn SA, Atreja A, Lewis JD, Moore TA, Rubin DT, Kim AM, Serra S, Nersesova Y, Fredell L, Hunsicker D, McDonald D, Knight R, Allegretti JR, Pekow J, Absah I, Hsu R, Vincent J, Khanna S, Tangen L, Crawford CV, Mattar MC, Chen LA, Fischer M, Arsenescu RI, Feuerstadt P, Goldstein J, Kerman D, Ehrlich AC, Wu GD, Laine L.: Fecal Microbiota Transplantation Is Highly Effective in Real-World Practice: Initial Results From the FMT National Registry. Gastroenterology 2021.

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Last updated: 11/30/2021
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