Deanne M. Taylor
Research Associate Professor of Pediatrics (General Pediatrics)
Director, Bioinformatics Group, Children's Hospital of Philadelphia, Department of Biomedical and Health Informatics, University of Pennsylvania
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
Biomedical and Health Informatics
3535 Market Street, Suite 1024
Philadelphia, PA 19104
Biomedical and Health Informatics
3535 Market Street, Suite 1024
Philadelphia, PA 19104
Email:
taylordm@chop.edu
taylordm@chop.edu
Publications
Education:
AA (General Studies, Honors)
North Shore Community College, 1991.
BA (Physics, Astronomy)
Wellesley College, 1995.
MS (Biophysics)
University of Michigan, 1998.
PhD (Biophysics)
University of Michigan, 2001.
AA (General Studies, Honors)
North Shore Community College, 1991.
BA (Physics, Astronomy)
Wellesley College, 1995.
MS (Biophysics)
University of Michigan, 1998.
PhD (Biophysics)
University of Michigan, 2001.
Post-Graduate Training
Postdoctoral Researcher, Bioinformatics, Pfizer Global R&D, Ann Arbor, MI, 2000-2001.
Permanent linkPostdoctoral Researcher, Bioinformatics, Pfizer Global R&D, Ann Arbor, MI, 2000-2001.
Description of Itmat Expertise
Bioinformatics, single-cell biology, cell models, applications of cell models to studying pediatric diseasesDescription of Research Expertise
Translational Computational Biology: Development of bioinformatics methods using mathematical and computational approaches to better understand the genetic contribution of biological variation to disease, coupling clinical information with high-dimensional biomedical data from next-gen sequencing, microarray, PCR, and proteomics experiments.Computational Systems Biology: approaches to understanding the effects of genetic variation on developing biological systems through analysis of functional genomics studies and associated contributions to disease. Modeling of biological systems.
Bioinformatics: Machine-learning methods development and use. Next-generation sequence analysis. Microarray analysis. Database and knowledge management and data mining.
Genetics and genomics of development and reproduction.
Selected Publications
Joseph W Guarnieri, Joseph M Dybas, Hossein Fazelinia, Man S Kim, Justin Frere, Yuanchao Zhang, Yentli Soto Albrecht, Deborah G Murdock, Alessia Angelin, Larry N Singh, Scott L Weiss, Sonja M Best, Marie T Lott, Shiping Zhang, Henry Cope, Victoria Zaksas, Amanda Saravia-Butler, Cem Meydan, Jonathan Foox, Christopher Mozsary, Yaron Bram, Yared Kidane, Waldemar Priebe, Mark R Emmett, Robert Meller, Sam Demharter, Valdemar Stentoft-Hansen, Marco Salvatore, Diego Galeano, Francisco J Enguita, Peter Grabham, Nidia S Trovao, Urminder Singh, Jeffrey Haltom, Mark T Heise, Nathaniel J Moorman, Victoria K Baxter, Emily A Madden, Sharon A Taft-Benz, Elizabeth J Anderson, Wes A Sanders, Rebekah J Dickmander, Stephen B Baylin, Eve Syrkin Wurtele, Pedro M Moraes-Vieira, Deanne Taylor, Christopher E Mason, Jonathan C Schisler, Robert E Schwartz, Afshin Beheshti, Douglas C Wallace: Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts. Science Translational Medicine 15(708): eabq1533, August 2023.Sperotto, Francesca and Gutiérrez-Sacristán, Alba and Makwana, Simran and Li, Xiudi and Rofeberg, Valerie N. and Cai, Tianxi and Bourgeois, Florence T. and Omenn, Gilbert S. and Hanauer, David A. and Sáez, Carlos and Bonzel, Clara-Lea and Bucholz, Emily and Dionne, Audrey and Elias, Matthew D. and Barrio, Noelia García and González González, Tomás and Issitt, Richard and Kate, Kernan F. and Laird-Gion, Jessica and Maidlow, Sarah E. and Mandl, Kenneth D. and Mohseni Ahooyi, Taha and Moraleda, Cinta and Morris, Michele and Moshal, Karyn and Pedrera Jiménez, Miguel and Shah, Mohsin A. and South, Andrew M. and Spiridou, Anastasia and Taylor, Deanne and Verdy, Guillaume and Visweswaran, Shyam and Wang, Xuan and Xia, Zongqi and Zachariasse, Joany M. and Newburger, Jane W. and Avillach, Paul, : Clinical Phenotypes and Outcomes in Children with Multisystem Inflammatory Syndrome Across Sars-CoV-2 Variant Eras: A Multinational Study from the 4CE Consortium. Lancet (preprint) http://dx.doi.org/10.2139/ssrn.4448626 July 2023 Notes: Available at SSRN: https://ssrn.com/abstract=4448626 or http://dx.doi.org/10.2139/ssrn.4448626
John Erol Evangelista, Daniel JB Clarke, Zhuorui Xie, Giacomo B Marino, Vivian Utti, Sherry L Jenkins, Taha Mohseni Ahooyi, Cristian G Bologa, Jeremy J Yang, Jessica L Binder, Praveen Kumar, Christophe G Lambert, Jeffrey S Grethe, Eric Wenger, Deanne Taylor, Tudor I Oprea, Bernard de Bono, Avi Ma’ayan: Toxicology knowledge graph for structural birth defects Communications Medicine 3(1), July 2023.
Min Heui Ha, Man S. Kim, Hyun-Ju An, Min-Ji Sung, Yu Ho Lee, Dong-Ho Yang, Sang Hyun Jung, Jihyun Baek, Yueun Choi, Deanne M. Taylor, Yuanchao Zhang, So-Young Lee, Hye Yun Jeong: PTEN-induced kinase 1 is associated with renal aging, via the cGAS-STING pathway. Aging Cell May 2023.
The 4CE Pediatric COVID-19 Consortium: Long-term kidney function recovery and mortality after COVID-19-associated acute kidney injury: An international multi-centre observational cohort study. Eclinicalmedicine. Elsevier, 55(101724), January 2023.
Alexa A Woodward, Deanne M Taylor, Elizabeth Goldmuntz, Laura E Mitchell, AJ Agopian, Jason H Moore, Ryan J Urbanowicz: Gene-Interaction-Sensitive enrichment analysis in congenital heart disease. BioData Mining 15(1): 1-16, December 2022 Notes: Role: Bioinformatics analyst, generated all data and aided in analysis, paper review, conception of the project.
Gutiérrez-Sacristán A, Serret-Larmande A, Hutch MR, Sáez C, Aronow BJ, Bhatnagar S, Bonzel C-L, Cai T, Devkota B, Hanauer DA, Loh NHW, Luo Y, Moal B, Ahooyi TM, Njoroge WFM, Omenn GS, Sanchez-Pinto LN, South AM, Sperotto F, Tan ALM, Taylor DM, Verdy G, Visweswaran S, Xia Z, Zahner J, Avillach P, Bourgeois FT, Consortium for Clinical Characterization of COVID-19 by EHR (4CE): Hospitalizations Associated With Mental Health Conditions Among Adolescents in the US and France During the COVID-19 Pandemic JAMA Network Open 5(12), December 2022.
Amanda M. Saravia-Butler, Jonathan C. Schisler, Deanne Taylor, Afshin Beheshti, Dan Butler, Cem Meydan, Jonathon Foox, Kyle Hernandez, Chris Mozsary, Christopher E. Mason, Robert Meller: Host transcriptional responses in nasal swabs identifies potential SARS-CoV-2 infection in PCR negative patients. iScience 25(11): 105310, November 2022.
Francisco J. Enguita, Ana Lúcia Leitão, J. Tyson McDonald, Viktorija Zaksas, Saswati Das, Diego Galeano, Deanne Taylor, Eve Syrkin Wurtele, Amanda Saravia-Butler, Stephen B. Baylin, Robert Meller, D. Marshall Porterfield, Douglas C. Wallace, Jonathan C. Schisler, Christopher E. Mason, Afshin Beheshti: The interplay between lncRNAs, RNA-binding proteins and viral genome during SARS-CoV-2 infection reveals strong connections with regulatory events involved in RNA metabolism and immune response. Theranostics 12(8): 3946-3962, May 2022 Notes: Role: Data analysis, writing, review.
Tianyu Cai, Agnès Gouble, Kathryn L Black, Anna Skwarska, Ammar S Naqvi, Deanne Taylor, Ming Zhao, Qi Yuan, Mayumi Sugita, Qi Zhang, Roman Galetto, Stéphanie Filipe, Antonio Cavazos, Lina Han, Vinitha Kuruvilla, Helen Ma, Connie Weng, Chang-Gong Liu, Xiuping Liu, Sergej Konoplev, Jun Gu, Guilin Tang, Xiaoping Su, Gheath Al-Atrash, Stefan Ciurea, Sattva S Neelapu, Andrew A Lane, Hagop Kantarjian, Monica L Guzman, Naveen Pemmaraju, Julianne Smith, Andrei Thomas-Tikhonenko, Marina Konopleva: Targeting CD123 in blastic plasmacytoid dendritic cell neoplasm using allogeneic anti-CD123 CAR T cells. Nature Communications 13(1): 1-11, April 2022 Notes: Role: Senior bioinformatics analyst on the project. Oversight, methods development, and paper review.