Kiran Musunuru

faculty photo
Associate Professor of Medicine
Director, Penn Cardiovascular Institute's Genetic and Epigenetic Origins of Disease Program, Perelman School of Medicine at the University of Pennsylvania
Scientific Director, Penn Center for Inherited Cardiovascular Disease, Hospital of the University of Pennsylvania
Department: Medicine

Contact information
3400 Civic Center Blvd, Bldg 421
11-104 Smilow Center for Translational Research
Philadelphia, PA 19104
Office: 215-573-4717
Graduate Group Affiliations
Education:
AB (Biochemical Sciences)
Harvard College, Cambridge, MA, 1997.
PhD (Biomedical Sciences)
The Rockefeller University, New York, NY, 2003.
MD (Medicine)
Weill-Cornell Medical College, New York, NY, 2004.
MPH (Epidemiology)
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 2009.
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Description of Itmat Expertise

Cardiovascular genetics, therapeutic genome editing

Selected Publications

Lv Wenjian, Qiao Lyon, Petrenko, Nataliya, Li Wenjun, Owens Anjali T, McDermott-Roe Chris, Musunuru Kiran: Functional Annotation of TNNT2 Variants of Uncertain Significance With Genome-Edited Cardiomyocytes. Circulation 138: 2852–2854, Dec 2018.

Rossidis Avery C, Stratigis John D, Chadwick Alexandra C, Hartman Heather A, Ahn Nicholas J, Li Haiying, Singh Kshitiz, Coons Barbara E, Li Li, Lv Wenjian, Zoltick Philip W, Alapati Deepthi, Zacharias William, Jain Rajan, Morrisey Edward E, Musunuru Kiran, Peranteau William H: In utero CRISPR-mediated therapeutic editing of metabolic genes. Nature medicine 24(10): 1513-1518, Oct 2018.

Wang Xiao, Musunuru Kiran: Confirmation of Causal rs9349379- PHACTR1 Expression Quantitative Trait Locus in Human-Induced Pluripotent Stem Cell Endothelial Cells. Circulation. Genomic and precision medicine 11(10): e002327, Oct 2018.

Musunuru Kiran, Arora Pankaj, Cooke John P, Ferguson Jane F, Hershberger Ray E, Hickey Kathleen T, Lee Jin-Moo, Lima João A C, Loscalzo Joseph, Pereira Naveen L, Russell Mark W, Shah Svati H, Sheikh Farah, Wang Thomas J, MacRae Calum A: Interdisciplinary Models for Research and Clinical Endeavors in Genomic Medicine: A Scientific Statement From the American Heart Association. Circulation. Genomic and precision medicine 11(6): e000046, Jun 2018.

Li Shuang, Li Mushan, Liu Xiaojian, Yang Yuanyuan, Wei Yuda, Chen Yanhao, Qiu Yan, Zhou Tingting, Feng Zhuanghui, Ma Danjun, Fang Jing, Ying Hao, Wang Hui, Musunuru Kiran, Shao Zhen, Zhao Yongxu, Ding Qiurong: Genetic and Chemical Screenings Identify HDAC3 as a Key Regulator in Hepatic Differentiation of Human Pluripotent Stem Cells. Stem cell reports May 2018.

Musunuru Kiran, Bernstein Daniel, Cole F Sessions, Khokha Mustafa K, Lee Frank S, Lin Shin, McDonald Thomas V, Moskowitz Ivan P, Quertermous Thomas, Sankaran Vijay G, Schwartz David A, Silverman Edwin K, Zhou Xiaobo, Hasan Ahmed A K, Luo Xiao-Zhong James: Functional Assays to Screen and Dissect Genomic Hits: Doubling Down on the National Investment in Genomic Research. Circulation. Genomic and precision medicine 11(4): e002178, Apr 2018.

Musunuru Kiran: Stem cell modeling of lipid genetics. Current opinion in lipidology 29(2): 151-155, Apr 2018.

Small Kerrin S, Todorčević Marijana, Civelek Mete, El-Sayed Moustafa Julia S, Wang Xiao, Simon Michelle M, Fernandez-Tajes Juan, Mahajan Anubha, Horikoshi Momoko, Hugill Alison, Glastonbury Craig A, Quaye Lydia, Neville Matt J, Sethi Siddharth, Yon Marianne, Pan Calvin, Che Nam, Viñuela Ana, Tsai Pei-Chien, Nag Abhishek, Buil Alfonso, Thorleifsson Gudmar, Raghavan Avanthi, Ding Qiurong, Morris Andrew P, Bell Jordana T, Thorsteinsdottir Unnur, Stefansson Kari, Laakso Markku, Dahlman Ingrid, Arner Peter, Gloyn Anna L, Musunuru Kiran, Lusis Aldons J, Cox Roger D, Karpe Fredrik, McCarthy Mark I: Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition. Nature genetics 50(4): 572-580, Apr 2018 Notes: co-senior author.

Musunuru Kiran: How genome editing could be used in the treatment of cardiovascular diseases. Personalized medicine 15(2): 67-69, Mar 2018.

Lin Jennie, Musunuru Kiran: From Genotype to Phenotype: A Primer on the Functional Follow-up of Genome-Wide Association Studies in Cardiovascular Disease. Circulation. Genomic and precision medicine 11(2): e001946, Feb 2018.

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Last updated: 12/13/2018
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