John T. Seykora

faculty photo
Professor of Dermatology
Member, Abramson Cancer Center, Hospital of the University of Pennsylvania
Department: Dermatology
Graduate Group Affiliations

Contact information
Department of Dermatology
Room 1011, Biomedical Research Building
421 Curie Blvd
Philadelphia, PA 19104-6142
Office: 2158980170
Fax: 2155732143
M.S. (Biochemistry)
University of Chicago, 1986.
B.A. (Biology with Honors)
University of Chicago, 1986.
Ph.D. (Cell Biology)
Rockefeller University, 1992.
M.D. (Medicine)
Cornell University Medical College, 1993.
Post-Graduate Training
Intern in Pathology, Hospital at the University of Pennsylvania, 1993-1994.
Resident in Pathology, Hospital of the University of Pennsylvania, 1994-1997.
Fellowship in Dermatopathology, Hospital of the University of Pennsylvania, 1997-1998.
Post-doctoral Fellowship, Department of Dermatology, University of Pennsylvania, 1998-1999.
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Description of Research Expertise

1. Keratinocyte growth and differentiation-mechanisms of growth control
2. Skin cancer-squamous cell carcinoma
3. Signal transduction-tyrosine kinases and adaptor molecules
4. Murine models of human diseases.
5. Use of organotypic cultures to model disease.
6. Effects of UVB on keratinocytes
7. Psoriasis
8. Dermatopathology-alopecia, appendageal tumors, cancer.

Description of Itmat Expertise

Cellular mechanisms that regulate keratinocyte growth.

In vivo models of skin cancer

Topical therapies for skin cancer

Selected Publications

Micheletti RG, Chansky PB, Haun PL, Seykora JT, Dekerlegand J, Sultan LR, Schultz SM, Sehgal CM, Sobanko JF: “Ablative fractional laser resurfacing for treatment of sclerosis and contractures in chronic graft-versus-host disease: A pilot study.” J Am Acad Dermatol 82(4): 984-986, Apr 2020 Notes: doi: 10.1016/j.jaad.2019.07.084. Epub 2019 Jul 30.

Flamm A, Moshiri AS, Roche F, Onyekaba G, Nguyen J, James AJ, Taylor S and Seykora J. : “Characterization of the Inflammatory Features of Central Centrifugal Cicatricial Alopecia” J Cutan Pathol Feb 2020 Notes: doi: 10.1111/cup.13666. [Epub ahead of print] PMID: 32068905.

Flamm A, Moshiri AS, Roche F, Onyekaba G, Nguyen J, James AJ, Taylor S and Seykora J. : “Characterization of the Inflammatory Features of Central Centrifugal Cicatricial Alopecia”. J Cutan Pathol. Feb 18 2020 Notes: doi: 10.1111/cup.13666. [Epub ahead of print] PubMed PMID: 32068905.

Lee V, Gober MD, Bashir H, O’Day C, Blair IA, Mesaros C, Weng L, Huang A, Chen A, Tang R, Anagnos V, Li JL, Roling S, Sagaityte E, Wang A, Lin C, Yeh C, Atillasoy C, Marshall C, Dentchev T, Ridky T, and Seykora JT.: “Voriconazole enhances UV-induced DNA damage by inhibiting catalase and promoting oxidative stress.” Exp Dermatol 29(1): 29-38, Jan 2020 Notes: doi: 10.1111/exd.14038. Epub 2019 Oct 29.

Natale C, Li J, Dentchev T, Capell B, Seykora J, Stanger B, and Ridky T. : “Pharmacologic Activation of G Protein-Coupled Estrogen Receptor Inhibits Pancreatic Ductal Adenocarcinoma.” Cellular and Molecular Gastroenterology and Hepatology. 2020 Notes: In press.

Szigety KM, Liu F, Yuan CY, Moran DJ, Horrell J, Gochnauer HR, Cohen RN, Katz JP, Kaestner KH, Seykora JT, Tobias JW, Lazar MA, Xu M, and Millar, SE. : “HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity.” Genes and Development 2020 Notes: In Press.

Chandrasekaran S, Sasaki M, Scharer CD, Kissick HT, Patterson DG, Magliocca KR, Seykora JT, Sapkota B, Gutman DA, Cooper LA, Lesinski GB, Waller EK, Thomas SN, Kotenko SV, Boss JM, Moreno CS, Swerlick RA, Pollack BP. : Phosphoinositide 3-Kinase Signaling Can Modulate MHC Class I and II Expression. Mol Cancer Res. 17(12): 2395-2409, Dec 2019 Notes: doi: 10.1158/1541-7786.MCR-19-0545. Epub 2019 Sep 23.

Ma SA, O'Day CP, Dentchev T, Takeshita J, Ridky TW, Seykora JT, Chu EY: Expression of p15 in a spectrum of spitzoid melanocytic neoplasms. J Cutan Pathol 46(5): 310-16, May 2019 Notes: doi: 10.1111/cup.13424.

Yang X, Daifallah AEM Shankar S, Beer J, Marshall C, Dentchev T, Seykora F, D'Armas S, Hahn J, Lee V, Sabry HH, Farag AM, Seykora JT: Topical kinase inhibitors induce regression of cutaneous squamous cell carcinoma. Exp Dermatol 28(5): 609-13, May 2019 Notes: doi: 10.1111/exd.13902.

Lee V, Yang X, Prouty S, Dentchev T, Marshall C, Maeno H, Bashir H, O'Day C, Seykora JT. : Srcasm regulates tyrosine kinases in skin cancer: Implications for precision medicine. Journal of Investigative Dermatology Symp Proc. 19(2): S103-S105, December 2018 Notes: Doi: 10.1016/j.jisp.2018.10.006.

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Last updated: 04/29/2020
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