Daniel P Kelly

faculty photo
Willard and Rhoda Ware Professor of Diabetes and Metabolic Diseases
Graduate Faculty Scholar, University of Central Florida
Senior Vice President for Research, Sanford Burnham Prebys
Department: Medicine

Contact information
3400 Civic Center Blvd.
Smilow Center for Translational Research
Philadelphia, PA 19104
Office: 215-898-0768
Lab: 215-898-2374
Graduate Group Affiliations
B.S. (Biology)
University of Illinois, 1978.
M.D. (Medicine )
University of Illinois College of Medicine, Chicago, Illinois, 1982.
Permanent link

Description of Itmat Expertise

The Kelly Lab is interested in the control of energy metabolism and mitochondrial function in the developing and diseased heart. 

Selected Publications

Lee Samuel, Leone Teresa C, Rogosa Lisa, Rumsey John, Ayala Julio, Coen Paul M, Fitts Robert H, Vega Rick B, Kelly Daniel P: Skeletal muscle PGC-1β signaling is sufficient to drive an endurance exercise phenotype and to counteract components of detraining in mice. American journal of physiology. Endocrinology and metabolism 312(5): E394-E406, May 2017.

Vega Rick B, Kelly Daniel P: Cardiac nuclear receptors: architects of mitochondrial structure and function. The Journal of clinical investigation 127(4): 1155-1164, Apr 2017.

Liang Xijun, Liu Lin, Fu Tingting, Zhou Qian, Zhou Danxia, Xiao Liwei, Liu Jing, Kong Yan, Xie Hui, Yi Fanchao, Lai Ling, Vega Rick B, Kelly Daniel P, Smith Steven R, Gan Zhenji: Exercise Inducible Lactate Dehydrogenase B Regulates Mitochondrial Function in Skeletal Muscle. The Journal of biological chemistry 291(49): 25306-25318, Dec 2016.

Liu Jing, Liang Xijun, Zhou Danxia, Lai Ling, Xiao Liwei, Liu Lin, Fu Tingting, Kong Yan, Zhou Qian, Vega Rick B, Zhu Min-Sheng, Kelly Daniel P, Gao Xiang, Gan Zhenji: Coupling of mitochondrial function and skeletal muscle fiber type by a miR-499/Fnip1/AMPK circuit. EMBO molecular medicine 8(10): 1212-1228, Oct 2016.

Ahn Byungyong, Soundarapandian Mangala M, Sessions Hampton, Peddibhotla Satyamaheshwar, Roth Gregory P, Li Jian-Liang, Sugarman Eliot, Koo Ada, Malany Siobhan, Wang Miao, Yea Kyungmoo, Brooks Jeanne, Leone Teresa C, Han Xianlin, Vega Rick B, Kelly Daniel P: MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling. The Journal of clinical investigation 126(9): 3567-79, Sep 2016.

Horton Julie L, Martin Ola J, Lai Ling, Riley Nicholas M, Richards Alicia L, Vega Rick B, Leone Teresa C, Pagliarini David J, Muoio Deborah M, Bedi Kenneth C, Margulies Kenneth B, Coon Joshua J, Kelly Daniel P: Mitochondrial protein hyperacetylation in the failing heart. JCI insight 2(1), Feb 2016.

Aubert Gregory, Martin Ola J, Horton Julie L, Lai Ling, Vega Rick B, Leone Teresa C, Koves Timothy, Gardell Stephen J, Krüger Marcus, Hoppel Charles L, Lewandowski E Douglas, Crawford Peter A, Muoio Deborah M, Kelly Daniel P: The Failing Heart Relies on Ketone Bodies as a Fuel. Circulation 133(8): 698-705, Feb 2016.

Gong Guohua, Song Moshi, Csordas Gyorgy, Kelly Daniel P, Matkovich Scot J, Dorn Gerald W: Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice. Science (New York, N.Y.) 350(6265): aad2459, Dec 2015.

Dorn Gerald W, Vega Rick B, Kelly Daniel P: Mitochondrial biogenesis and dynamics in the developing and diseased heart. Genes & development 29(19): 1981-91, Oct 2015.

Liao Xudong, Zhang Rongli, Lu Yuan, Prosdocimo Domenick A, Sangwung Panjamaporn, Zhang Lilei, Zhou Guangjin, Anand Puneet, Lai Ling, Leone Teresa C, Fujioka Hisashi, Ye Fang, Rosca Mariana G, Hoppel Charles L, Schulze P Christian, Abel E Dale, Stamler Jonathan S, Kelly Daniel P, Jain Mukesh K: Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis. The Journal of clinical investigation 125(9): 3461-76, Sep 2015.

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Last updated: 11/06/2017
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