Alain H. Rook

faculty photo
Professor of Dermatology
Department: Dermatology

Contact information
Department of Dermatology
14 Penn Tower
One Convention Avenue
Philadelphia, PA 19104
Office: 215-662-6751
Fax: 215-349-8173
B.A. (Biology)
Brandeis University, 1971.
M.D. (Medicine)
University of Michigan, 1975.
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Description of Itmat Expertise

Dr. Rook's current research focuses on immunotherapeutic approaches to cutaneous T-cell lymphoma including 1) the development of novel immunomodulatory agents for therapy, 2) the elucidation of mechanisms of action of new therapeutic agents and 3) the mechanisms for the endogenous immunosuppression caused by the malignant T-cells in CTCL

Selected Publications

Gardner JM, Introcaso CE, Nasta SD, Kim EJ, Vittorio CC and Rook AH: A novel regimen of vorinostat with interferon gamma for refractory Sezary syndrome. J Amer Acad Dermatol 61(1): 112-116, July 2009.

Hoeller C, Richardson SK, Ng LG, Valero T, Wysocka M, Rook AH and Weninger W: In vivo imaging of cutaneous T cell lymphoma migration to the skin. Cancer Res 69(7): 2704-2708, April 2009.

Gardner JM, Evans KG, Musiek A, Rook AH and Kim EJ: Update on Treatment of cutaneous T cell lymphoma. Curr Opin Oncol 21(2): 131-137, March 2009.

Gardner J, Evans K, Goldstein S, Kim EJ, Vittorio CC and Rook AH: Vorinostat for the treatment of bullous pemphigoid in the setting of advanced refractory cutaneous T cell lymphoma. Cutting Edge Section, Arch Dermatol Page: In Press, 2009.

Contassot E, Kerl K, Roques, Shane R, Rook AH and French LE: Resistance to FasL and TRAIL-mediated apoptosis in Sezary Syndrome T cells associated with impaired death receptor and cFLIP expression. Blood 111(9): 4780-4787, 2008.

Avarbock AB, Loren AW, Park JY, Junkins-Hopkins JM, Choi J, Litzky LA and Rook AH: Lethal vascular leak syndrome after denileukin diftitox administration to a patient with cutaneous gamma/delta T cell lymphoma and occult cirrhosis. Am J Hematol 83(7): 593-595, 2008.

Introcaso CE, Leber B, Greene K, Ubriani R, Rook AH and Kim EJ: Stem cell transplantation in advanced cutaneous T cell lymphoma. J Amer Acad Dermatol 58(4): 645-649, 2008.

Introcaso CE, Micaily B, Richardson SK, Junkins-Hopkins JM, Yoon JS, Kim EJ, Vittorio CC and Rook AH: Total skin electron beam therapy may be associated with improvement of peripheral blood disease in Sezary Syndrome. J Amer Acad Dermatol 58(4): 592-595, 2008.

Yoon JS, Wysocka M, Troxel AB, Newton SB, Hess SD, Richardson SK, Lin JH, Benoit BM, Kasprzycka M, Wasik MA and Rook AH : Interleukin-21 enhances antitumor responses without stimulating proliferation of malignant T cells of patient with leukemic cutaneous T cell lymphoma. J Invest Dermatol 128(2): 473-480, 2008.

Lin JH, Kim EJ, Bansal A, Seykora J, Richardson SK, Cha XY, Zafar S, Nasta S, Wysocka M, Benoit B, Rook AH and Fakharzadeh SS: Clinical and in vitro resistance to bexarotene in adult T cell leukemia: Loss of RXR-alpha receptor. Blood 112(6): 2484-2488, 2008.

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Last updated: 05/28/2013
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