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Thomas P. Cappola, MD, ScM

William Smilow Professor
Department: Medicine

Contact information
Perelman Center for Advanced Medicine
Division of Cardiovascular Medicine
11-113 South Pavilion
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-662-3140
Fax: 215-349-8017
Lab: 215-573-4717
Graduate Group Affiliations
A.B. (Chemistry)
Princeton University, 1991.
M.D. (Medicine)
Harvard Medical School, 1995.
Sc.M. (Clinical Investigation )
Johns Hopkins Bloomberg School of Public Health, 2004.
Post-Graduate Training
Intern and Resident, Internal Medicine, Brigham and Women’s Hospital, 1995-1998.
Clinical and Research Fellow, Cardiovascular Disease, Johns Hopkins Hospital, 1998-2002.
Heart Failure and Transplantation Fellow, Johns Hopkins Hospital, 2000-2001.
Research Fellow, National Heart, Lung, and Blood Institute Program in Genomic Applications, Johns Hopkins Medical Institutions, 2001-2002.
Honorary Senior Visiting Fellow, University of Cambridge, UK, 2013-2014.
Enhancing Leadership 1.0, Department of Medicine Executive Committee, University of Pennsylvania Perelman School of Medicine, 2016-2018.
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Description of Research Expertise

Thomas Cappola is the William Smilow Professor and Chief, Cardiovascular Medicine, University of Pennsylvania Perelman School of Medicine. His research aims to uncover heart failure mechanisms in human subjects and to use these insights to improve treatment. This has involved diverse approaches, including applied genomics, population science, laboratory studies, and clinical trials. He has established and leads a multicenter cohort study of advanced heart failure (Penn Heart Failure Study, PHFS); co-loads a multicenter consortium for human myocardial transcriptomics and systems genetics (Myocardial Applied Genomics Network, MAGNet); serves as a Principal Investigator on the NHLBI Heart Failure Clinical Research Network; and is a contributing member of numerous international genomics consortia. Within the Cardiovascular Division, he has established collaborative leadership to create programs integrating science and clinical care, and has used these as a platform for research and training. In his clinical role, he treats patients with advanced heart failure on the inpatient and outpatient heart failure/transplant service.

Description of Clinical Expertise

My clinical focus is evaluation and treatment of advance heart failure including medical therapy, device therapy, investigational therapy, and cardiac transplantation

Selected Publications

Guo Z, Valenzuela Ripoll C, Picataggi A, Rawnsley DR, Ozcan M, Chirinos JA, Chendamarai E, Girardi A, Riehl T, Evie H, Diab A, Kovacs A, Hyrc K, Ma X, Asnani A, Shewale SV, Scherrer-Crosbie M, Cowart LA, Parks JS, Zhao L, Gordon D, Ramirez-Valle F, Margulies KB, Cappola TP, Desai AA, Pedersen LN, Bergom C, Stitziel NO, Rettig MP, DiPersio JF, Hajny S, Christoffersen C, Diwan A, Javaheri A: Apolipoprotein M attenuates athracycline cardiotoxicity and lysosomaliInjury. JACC Basic Transl Sci 8(3): 340-355, Jan 2023.

Spurrell CH, Barozzi I, Kosicki M, Mannion BJ, Blow MJ, Fukuda-Yuzawa Y, Slaven N, Afzal SY, Akiyama JA, Afzal V, Tran S, Plajzer-Frick I, Novak CS, Kato M, Lee EA, Garvin TH, Pham QT, Kronshage AN, Lisgo S, Bristow J, Cappola TP, Morley MP, Margulies KB, Pennacchio LA, Dickel DE, Visel A: Genome-wide fetalization of enhancer architecture in heart disease. Cell Rep. 40(12): 111400, Sep 2022.

Chirinos JA, Zhao L, Reese-Petersen AL, Cohen JB, Genovese F, Richards AM, Doughty RN, Díez J, González A, Querejeta R, Zamani P, Nuñez J, Wang Z , Ebert C, Kammerhoff K, Maranville J, Basso M, Qian C, Rasmussen DGK, Schafer PH, Seiffert D, Karsdal M, Gordon DA, Ramirez-Valle F, Cappola TP: Endotrophin, a collagen VI formation–derived peptide, in heart failure. NEJM Evidence 1(9): EVIDoa2200091, Sep 2022.

Flam E, Jang C, Murashige D, Yang Y, Morley MP, Jung S, Kantner DS, Pepper H, Bedi KC, Brandimarto J, Prosser BL, Cappola T, Snyder NW, Rabinowitz JD, Margulies KB, Arany Z: Integrated landscape of cardiac metabolism in end-stage human nonischemic dilated cardiomyopathy. Nat Cardiovasc Res 1: 817-829, Sep 2022.

Javaheri A, Diab A, Zhao L, Qian C, Cohen JB, Zamani P, Kumar A, Wang Z, Ebert C, Maranville J, Kvikstad E, Basso M, van Empel V, Richards AM, Doughty RN, Rietzschel E, Kammerhoff K, Gogain J, Schafer P, Seiffert DA, Gordon DA, Ramirez-Valle F, Mann DL, Cappola TP, Chirinos JA: Proteomic analysis of effects of spironolactone in heart failure with preserved ejection fraction. Circ Heart Fail 15(9): e009693, Aug 2022.

Reza N, Edwards JJ, Katcoff H, Mondal A, Griffis H, Rossano JW, Lin KY, Holzhauser HL, Wald JW, Owens AT, Cappola TP, Birati EY, Edelson JB: Sex differences in left ventricular assist device-related emergency department encounters in the United States. J Card Fail 28(9): 1445-1455, May 2022.

Lumbers RT, Shah S...Cappola TP, Ellinor PT, Vasan RS, Smith JG: The genomics of heart failure: design and rationale of the HERMES consortium. ESC Heart Fail 8(6): 5531-5541, Dec 2021.

McAfee Q, Chen CY, Yang Y, Caporizzo MA, Morley M, Babu A, Jeong S, Brandimarto J, Bedi KC Jr, Flam E, Cesare J, Cappola TP, Margulies K, Prosser B, Arany Z.: Truncated titin proteins in dilated cardiomyopathy. Sci Transl Med 13(618): eabd7287, Nov 2021.

Parcha V, Patel N, Musunuru K, Margulies KB, Cappola TP, Halade G, Wang TJ, Arora G, Arora P: Natriuretic peptide deficiency in obese individuals: mechanistic insights from healthy organ donor cohort. J Am Coll Cardiol 77(24): 3138-3140, Jun 2021.

Parcha V, Patel N, Gutierrez OM, Li P, Gamble KL, Musunuru K, Margulies KB, Cappola TP, Wang TJ, Arora G, Arora P.: Chronobiology of natriuretic peptides and blood pressure in lean and obese individuals. J Am Coll Cardiol 77(18): 2291-2303, May 2021.

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Last updated: 07/18/2023
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